Clinical phenotype and genetic associations in autosomal dominant familial Alzheimer's disease: a case series.

Abstract

The causes of phenotypic heterogeneity in familial Alzheimer's disease with autosomal dominant inheritance are not well understood. We aimed to characterise clinical phenotypes and genetic associations with APP and PSEN1 mutations in symptomatic autosomal dominant familial Alzheimer's disease (ADAD).

PMID:27777022 | DOI:S1474-4422(16)30193-4