Abstract
Alzheimers Dement (Amst). 2026 Jun 7;18(2):e70383. doi: 10.1002/dad2.70383. eCollection 2026 Apr-Jun.
ABSTRACT
INTRODUCTION: We examined the extent to which insulin resistance (IR), type 2 diabetes mellitus, obesity, and kidney function are associated with plasma phosphorylated tau (p-tau) concentrations (p-tau181, p-tau217, p-tau231) in the same cohort and the contribution of these factors on amyloid positron emission tomography (PET) concordance and longitudinal p-tau levels.
METHODS: We analyzed data from 287 participants using partial Spearman rho, Mann-Whitney U, receiver operating characteristic analysis, and linear mixed models.
RESULTS: Concordance between plasma p-tau217 and amyloid PET was not influenced by IR or estimated glomerular filtration rate (eGFR). Accounting for eGFR improved concordance of p-tau181 and p-tau231 with amyloid PET. Age, binarized waist-to-hip ratio, and amyloid status were associated with all longitudinal p-tau concentrations, and eGFR associated with longitudinal p-tau231.
DISCUSSION: Metabolic factors may influence the interpretation of longitudinal plasma p-tau concentrations and kidney function may influence amyloid PET concordance for p-tau181 and p-tau231, potentially necessitating analyte-specific adjustments or considerations in clinical interpretation.
PMID:42266204 | PMC:PMC13243186 | DOI:10.1002/dad2.70383
UK DRI Authors
