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J Neurol Neurosurg Psychiatry
Published

Neuroinflammation predicts disease progression in progressive supranuclear palsy.

Authors

Maura Malpetti, Luca Passamonti, Peter Simon Jones, Duncan Street, Timothy Rittman, Timothy D Fryer, Young T Hong, Patricia Vàsquez Rodriguez, William Richard Bevan-Jones, Franklin I Aigbirhio, John Tiernan O'Brien, James Benedict Rowe

Abstract

In addition to tau pathology and neuronal loss, neuroinflammation occurs in progressive supranuclear palsy (PSP). However, the prognostic value of the in vivo imaging markers for these processes in PSP remains unclear. We test the primary hypothesis that baseline in vivo imaging assessment of neuroinflammation in subcortical regions predicts clinical progression in patients with PSP.

PMID:33731439 | DOI:

UK DRI Authors

Maura Malpetti profile

Dr Maura Malpetti

Emerging Leader

Using specialist brain scans and novel blood tests to measure inflammation and accelerate the development of new treatments

Dr Maura Malpetti