Abstract
Alzheimers Dement. 2026 Jun;22(6):e71545. doi: 10.1002/alz.71545.
ABSTRACT
INTRODUCTION: High-risk plasma p-tau217 levels predict amyloid-β pathology in Alzheimer's disease, but little is known about the prevalence and temporal dynamics in the general population.
METHODS: Participants from the Gothenburg H70 Birth Cohort Study in Sweden were examined (n = 1157) and re-examined after 5-7 years (n = 771). Prevalence and 5-7 year transition of high-risk plasma p-tau217 status was determined among community-dwelling 70-year-olds.
RESULTS: High-risk plasma p-tau217 prevalence was 3.6% at age 70 and 7.0% at age 75-77 years. Eighty-nine percent remained low-risk and 4% converted to high-risk at follow-up. Prevalence of dementia at follow-up was 1.7% if remaining in the low-risk group and 21.4% if transitioning to the high-risk group. Prevalence of dementia among participants staying in the high-risk group was 16.7% at follow-up.
DISCUSSION: Individuals with low-risk plasma p-tau217 were unlikely to transition over 5-7 years. However, transitioning to a higher risk-category was associated with a higher prevalence of cognitive disability.
PMID:42252493 | DOI:10.1002/alz.71545
UK DRI Authors
