Dr Amanda Heslegrave

Principal Research Fellow

Co-leading the UK DRI Biomarker Factory platform based at UK DRI at UCL

Biography

Dr. Amanda Heslegrave is Principal Research Fellow at the UK DRI at UCL, where she co-leads the fluid biomarker (Zetterberg) laboratory and the UK DRI Biomarker Factory. After completing her BSc from Birkbeck, University of London (2000) and PhD from UCL (2005), she transitioned to biomarker research in 2012 with Prof Henrik Zetterberg at UCL. Her research focuses on fluid biomarkers in CSF and blood, utilising immunoassay and proteomic methods to study neurodegenerative diseases. 

News

Key publications

Scientific reports
Published

Impact of meningoencephalitis and sepsis on delirium and subsequent neurological impairment in pediatric patients: a prospective proof-of-concept biomarker and EEG study

Authors
Felix Klawitter, Johanna Hackenberg, Lena Danckert, Astrid Bertsche, Axel Petzold, Heidi A B Smith, Eugene Wesley Ely, Christian Spang, Rika Bajorat, Dagmar-Christiane Fischer, Gerd Klinkmann, Anne Körmann-Günther, Robert Fleischmann, Amanda Heslegrave, Henrik Zetterberg, Hessel Peters-Sengers, Johannes Ehler, Critical Care Consultant
Impact of meningoencephalitis and sepsis on delirium and subsequent neurological impairment in pediatric patients: a prospective proof-of-concept biomarker and EEG study
Multiple sclerosis (Houndmills, Basingstoke, England)
Published

Biomarker discovery using NUcleic Acid-Linked Immuno-Sandwich Assay in multiple sclerosis patients experiencing progression independent of relapse activity

Authors
Sofia Sandgren, Aleksandra Maleska Maceski, Pascal Benkert, Maximilian Einsiedler, Sabine Schaedelin, Johanna Oechtering, Lutz Achtnichts, Patrice H Lalive, Stefanie Müller, Caroline Pot, Amanda Heslegrave, David Hunt, Jan Lycke, Robert Hoepner, Patrick Roth, Claudio Gobbi, Manuel Comabella, Tobias Derfuss, Ludwig Kappos, Cristina Granziera, Ahmed Abdelhak, David Leppert, Eline Aj Willemse, Henrik Zetterberg, Jens Kuhle
Biomarker discovery using NUcleic Acid-Linked Immuno-Sandwich Assay in multiple sclerosis patients experiencing progression independent of relapse activity
The Lancet regional health. Europe
Published

Progression of biological markers in spinocerebellar ataxia type 3: longitudinal analysis of prospective data from the ESMI cohort

Authors
Moritz Berger, Hector Garcia-Moreno, Mónica Ferreira, Jeannette Hubener-Schmid, Tamara Schaprian, Philipp Wegner, Tim Elter, Kennet M Teichmann, Magda M Santana, Marcus Grobe-Einsler, Demet Oender, Berkan S C Koyak, Sarah Bernsen, Luís Pereira de Almeida, Patrick Silva, Joana Afonso Ribeiro, Inês Cunha, Cristina Gonzalez-Robles, Shamsher Khan, Amanda Heslegrave, Henrik Zetterberg, Manuela Lima, Mafalda Raposo, Ana F Ferreira, João Vasconcelos, Bart P van de Warrenburg, Judith van Gaalen, Teije H van Prooije, Jeroen de Vries, Ludger Schols, Olaf Riess, Matthis Synofzik, Dagmar Timmann, Andreas Thieme, Friedrich Erdlenbruch, Jon Infante, Ana L Pelayo-Negro, Leire Manrique, Kathrin Reetz, Imis Dogan, Gulin Oz, James M Joers, Khalafalla Bushara, Chiadikaobi Onyike, Michal Povazan, Heike Jacobi, Jeremy D Schmahmann, Eva-Maria Ratai, Matthias Schmid, Paola Giunti, Thomas Klockgether, Jennifer Faber
Progression of biological markers in spinocerebellar ataxia type 3: longitudinal analysis of prospective data from the ESMI cohort
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Identifying subphenotypes of patients undergoing post-operative delirium assessment

Authors
Emily Margaret Louise Bowman, Daniel F McAuley, Bernadette McGuinness, Anthony P Passmore, David Beverland, Henrik Zetterberg, Jonathan M Schott, Amanda Heslegrave, Elena Veleva, Rhiannon Laban, Aoife Sweeney, Emma L Cunningham
Identifying subphenotypes of patients undergoing post-operative delirium assessment

The Biomarker Factory

Dr Amanda Heslegrave co-leads the UK DRI Biomarker Factory, transforming the early detection, diagnosis and monitoring of dementia, by facilitating the development of fluid biomarkers for research and the clinic

UK DRI Biomarker Factory
Scientists posing in the lab in white coats