Dr Audrey Chagnot

PhD

Postdoctoral Researcher

Blood brain barrier, pericytes, brain ageing, dementia

Condition

Alzheimer's disease, Vascular dementia

Topics

Ageing, Vascular system

Techniques

Advanced microscopy & imaging, Mouse in vivo imaging

Biography

I joined the Montagne lab in February 2022. I completed my PhD in the Pathophysiology and Imaging of Neurological Disorders team (INSERM U1237) at the University of Caen Normandy, France, where I developped Magnetic Resonance Imaging protocols to study the glymphatic system in mice.

Research interest

I focus my research within the Montagne Lab on understanding how the pericytes regulate the neurovascular coupling and the blood-brain barrier permeability in brain capillaries. For this purpose, I developed image processing tool for microscopy to investigate subtle changes in cellular morphology. By understanding the fundamental mechanisms behind microvascular dysfunction, I aim to discover new therapeutic options against brain ageing and dementia.

Key publications

Current biology : CB
Published

The blood-brain barrier

Authors
Audrey Chagnot, Axel Montagne
The blood-brain barrier
Neuron
Published

Microglia protect against age-associated brain pathologies

Authors
David A D Munro, Nadine Bestard-Cuche, Conor McQuaid, Audrey Chagnot, Sepideh Kiani Shabestari, Jean Paul Chadarevian, Upasana Maheshwari, Stefan Szymkowiak, Kim Morris, Mehreen Mohammad, Andrea Corsinotti, Barry Bradford, Neil Mabbott, Ross J Lennen, Maurits A Jansen, Clare Pridans, Barry W McColl, Annika Keller, Mathew Blurton-Jones, Axel Montagne, Anna Williams, Josef Priller
Microglia protect against age-associated brain pathologies

Links