Caleb Webber

Prof Caleb Webber

Director of Data Science & Group Leader

Combining state-of-the-art stem cell models with bioinformatics techniques to boost our understanding of the biological mechanisms underlying Parkinson’s disease

Condition

Parkinson's disease

Biography

Prof Caleb Webber is combining state-of-the-art stem cell models with bioinformatics techniques to boost our understanding of the biological mechanisms underlying Parkinson’s disease. He is also aiming to identify new risk genes and investigate how these impact on the function of neurons. The team are also using advanced computational methods to investigate how genetic risk factors can influence a varying symptoms presented by patients. They hope to pinpoint key biological pathways that could be targeted with new drugs to prevent or treat Parkinson’s disease– and potentially other diseases with overlapping molecular causes.

In 2022, Prof Webber took on the additional role of UK DRI Director of Data Science. In this role, he is responsible for developing and implementing an Institute-wide strategy to harness the power of data resources and tools in our mission to find new treatments and technologies for dementia.

News

Key publications

Cereb Circ Cogn Behav
Published
A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia.
Authors
Sarmi Sri, Adam Greenstein, Alessandra Granata, Alex Collcutt, Angela C C Jochems, Barry W McColl, Blanca Díaz Castro, Caleb Webber, Carmen Arteaga Reyes, Catherine Hall, Catherine B Lawrence, Cheryl Hawkes, Chrysia-Maria Pegasiou-Davies, Claire Gibson, Colin L Crawford, Colin Smith, Denis Vivien, Fiona H McLean, Frances Wiseman, Gaia Brezzo, Giovanna Lalli, Harry A T Pritchard, Hugh S Markus, Isabel Bravo-Ferrer, Jade Taylor, James Leiper, Jason Berwick, Jian Gan, John Gallacher, Jonathan Moss, Jozien Goense, Letitia McMullan, Lorraine Work, Lowri Evans, Michael S Stringer, Mlj Ashford, Mohamed Abulfadl, Nina Conlon, Paresh Malhotra, Philip Bath, Rebecca Canter, Rosalind Brown, Selvi Ince, Silvia Anderle, Simon Young, Sophie Quick, Stefan Szymkowiak, Steve Hill, Stuart Allan, Tao Wang, Terry Quinn, Tessa Procter, Tracy D Farr, Xiangjun Zhao, Zhiyuan Yang, Atticus H Hainsworth, Joanna M Wardlaw
A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia.
Cell Stem Cell
Published
Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes.
Authors
Charmaine Lang, Kieran R Campbell, Brent J Ryan, Phillippa Carling, Moustafa Attar, Jane Vowles, Olga V Perestenko, Rory Bowden, Fahd Baig, Meike Kasten, Michele T Hu, Sally A Cowley, Caleb Webber, Richard Wade-Martins
Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes.

Webber Lab

Explore the work of the Webber Lab, combining state-of-the-art stem cell models with bioinformatics techniques to boost our understanding of the biological mechanisms underlying Parkinson’s disease

Webber Lab
Graphic representation of data plotted