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Prof David Hunt

Group Leader

Investigating how innate immune activation causes damage to the microvasculature of the brain

Biography

Prof David Hunt is a Wellcome Trust Senior Clinical Fellow and Consultant Neurologist based in Edinburgh University who leads clinics and research in the field of brain inflammation. He trained in medicine at Cambridge, London and Basel. His PhD research at Cambridge University was in the field of developmental neuroscience and neuroinflammation. In 2009 he moved to Edinburgh where he completed his neurological training and established a Wellcome Trust-funded laboratory to study the molecular basis of neuroinflammatory diseases. David’s research programme at the UK DRI aim to find ways to target inflammation to stop neurodegeneration, with particular focus on the interplay between interferon, nucleases and microvascular brain disease. This research programme links up clinics, discovery science and clinical trials.

News

Key publications

J Exp Med
Published
Detection of interferon alpha protein reveals differential levels and cellular sources in disease.
Authors
Mathieu P Rodero, Jérémie Decalf, Vincent Bondet, David Hunt, Gillian I Rice, Scott Werneke, Sarah L McGlasson, Marie-Alexandra Alyanakian, Brigitte Bader-Meunier, Christine Barnerias, Nathalia Bellon, Alexandre Belot, Christine Bodemer, Tracy A Briggs, Isabelle Desguerre, Marie-Louise Frémond, Marie Hully, Arn M J M van den Maagdenberg, Isabelle Melki, Isabelle Meyts, Lucile Musset, Nadine Pelzer, Pierre Quartier, Gisela M Terwindt, Joanna Wardlaw, Stewart Wiseman, Frédéric Rieux-Laucat, Yoann Rose, Bénédicte Neven, Christina Hertel, Adrian Hayday, Matthew L Albert, Flore Rozenberg, Yanick J Crow, Darragh Duffy
Detection of interferon alpha protein reveals differential levels and cellular sources in disease.
N Engl J Med
Published
Thrombotic microangiopathy associated with interferon beta.
Authors
David Hunt, David Kavanagh, Iain Drummond, Belinda Weller, Chris Bellamy, James Overell, Stephen Evans, Andrew Jackson, Siddharthan Chandran
Thrombotic microangiopathy associated with interferon beta.

Hunt Lab

Explore the work of the Hunt Lab, Investigating how innate immune activation causes damage to the microvasculature of the brain

Hunt Lab
Small blood vessels in mice