Gabriel Balmus

Prof Gabriel Balmus

Group Leader

Identifying genetic and environmental factors involved in DNA damage, neurodegeneration and ageing in neurons

Condition

Huntington's disease, Motor neuron disease/ALS, Parkinson's disease, Alzheimer's disease

Biography

Interested in the mechanisms controlling the maintenance of nuclear and mitochondrial genomes in mature neurons, Prof Gabriel Balmus joined the UK DRI at Cambridge in 2018. Obtaining his PhD in Molecular and Integrative Physiology in 2013 at Cornell University, USA, he went on to complete postdoctoral training at the Gurdon Institute at University of Cambridge and the Wellcome Trust Sanger Institute. As Group Leader, Gabriel brings his wealth of expertise to research genomic instability in neurodegenerative diseases.

News

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Targeting DNA repair for dementia treatments

To bring together expertise and identify strategies for translation in this emerging field, we formed...

Learn more Targeting DNA repair for dementia treatments

Key publications

Nat Protoc
Published
Derivation and maintenance of mouse haploid embryonic stem cells.
Authors
Ulrich Elling, Michael Woods, Josep V Forment, Beiyuan Fu, Fengtang Yang, Bee Ling Ng, Jose R Vicente, David J Adams, Brendan Doe, Stephen P Jackson, Josef M Penninger, Gabriel Balmus
Derivation and maintenance of mouse haploid embryonic stem cells.
Nat Commun
Published
ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks.
Authors
Gabriel Balmus, Domenic Pilger, Julia Coates, Mukerrem Demir, Matylda Sczaniecka-Clift, Ana C Barros, Michael Woods, Beiyuan Fu, Fengtang Yang, Elisabeth Chen, Matthias Ostermaier, Tatjana Stankovic, Hannes Ponstingl, Mareike Herzog, Kosuke Yusa, Francisco Munoz Martinez, Stephen T Durant, Yaron Galanty, Petra Beli, David J Adams, Allan Bradley, Emmanouil Metzakopian, Josep V Forment, Stephen P Jackson
ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks.
Nat Commun
Published
Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome.
Authors
Gabriel Balmus, Delphine Larrieu, Ana C Barros, Casey Collins, Monica Abrudan, Mukerrem Demir, Nicola J Geisler, Christopher J Lelliott, Jacqueline K White, Natasha A Karp, James Atkinson, Andrea Kirton, Matt Jacobsen, Dean Clift, Raphael Rodriguez, , David J Adams, Stephen P Jackson
Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome.
Genes Dev
Published
Synthetic lethality between PAXX and XLF in mammalian development.
Authors
Gabriel Balmus, Ana C Barros, Paul W G Wijnhoven, Chloé Lescale, Hélène Lenden Hasse, Katharina Boroviak, Carlos le Sage, Brendan Doe, Anneliese O Speak, Antonella Galli, Matt Jacobsen, Ludovic Deriano, David J Adams, Andrew N Blackford, Stephen P Jackson
Synthetic lethality between PAXX and XLF in mammalian development.

Balmus Lab

Explore the work of the Balmus lab, aiming to identify neuroprotective mechanisms against genomic instability accrual in ageing and neurodegeneration. 

Balmus lab
Image of a brain organoid