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Jo Jackson

Dr Johanna Jackson

Emerging Leader

Investigating synaptic vulnerability in Alzheimer's

Techniques

Advanced microscopy & imaging, Drug screening, Mass spec-based proteomics

Biography

Dr Jo Jackson is an Advanced Research Fellow, Alzheimer's Society Dementia Research Leader, the first recipient of the Alzheimer's Society's Carol Jennings Fellowship and an Emerging Leader at the UK DRI at Imperial. Her group takes a multi-‘omic and imaging approach to provide a mechanistic insight into the vulnerability of synaptic components in Alzheimer’s disease. This enables her group to identify and test molecular targets to achieve the vision of therapeutically targeting the synapse in Alzheimer's.

After her PhD at Imperial and post docs at Lund University and Imperial, Jo joined Eli Lilly where she became a team leader leading a research group studying the synapse changes in Alzheimer’s and co-chaired their Neuroplasticity Drug Discovery platform. Since returning to Imperial she has led the £2million Multi-‘omics Atlas Project at the UK DRI at Imperial; an open resource dedicated to the comprehensive, multi-‘omic mapping of the cellular pathology of Alzheimer's. Jo has extensive experience in studying synaptic integration in humans and in animal models of Alzheimer's, axonal injury and epilepsy both in industry and academia. 

News

Key publications

Nature genetics
Published
Cell state-dependent allelic effects and contextual Mendelian randomization analysis for human brain phenotypes
Authors
Alexander Haglund, Verena Zuber, Maya Abouzeid, Yifei Yang, Jeong Hun Ko, Liv Wiemann, Maria Otero-Jimenez, Louwai Muhammed, Rahel Feleke, Alexi Nott, James D Mills, Liisi Laaniste, Djordje O Gveric, Daniel Clode, Ann C Babtie, Susanna Pagni, Ravishankara Bellampalli, Alyma Somani, Karina McDade, Jasper J Anink, Lucia Mesarosova, Nurun Fancy, Nanet Willumsen, Amy Smith, Johanna Jackson, Javier Alegre-Abarrategui, Eleonora Aronica, Paul M Matthews, Maria Thom, Sanjay M Sisodiya, Prashant K Srivastava, Dheeraj Malhotra, Julien Bryois, Leonardo Bottolo, Michael R Johnson
Cell state-dependent allelic effects and contextual Mendelian randomization analysis for human brain phenotypes
Nat Biomed Eng
Published
Closed-loop optogenetic control of the dynamics of neural activity in non-human primates.
Authors
B Zaaimi, M Turnbull, A Hazra, Y Wang, C Gandara, F McLeod, E E McDermott, E Escobedo-Cousin, A Shah Idil, R G Bailey, S Tardio, A Patel, N Ponon, J Gausden, D Walsh, F Hutchings, M Kaiser, M O Cunningham, G J Clowry, F E N LeBeau, T G Constandinou, S N Baker, N Donaldson, P Degenaar, A O'Neill, A J Trevelyan, A Jackson
Closed-loop optogenetic control of the dynamics of neural activity in non-human primates.

Jackson Lab

Explore the work of the Jackson Lab focused on investigating vulnerable synaptic components to identify and test molecular targets to therapeutically target the synapse in Alzheimer's