Prof Sir John Hardy

Group Leader

Harnessing genetics to build a better understanding of dementia

Condition

Alzheimer's disease, Parkinson's disease

Topics

Genetics

Biography

Prof Sir John Hardy is a world-leading neurogeneticist in the field of neurodegenerative diseases, receiving numerous accolades that include the Breakthrough Prize in Life Sciences, the Brain Prize, election as a Fellow of the Royal Society and, in 2022, a knighthood for his contributions to science and health. In 1991, Hardy's team uncovered the first mutation directly implicated in Alzheimer's disease leading to the formulation of the highly influential 'amyloid-cascade' hypothesis. His extensive body of work in genetics will be built upon in this UK DRI programme, where the team will unravel pathogenic networks in neurodegenerative disease.

News

Key publications

Nature genetics
Published
PLCG2 downregulation impairs synaptic function and increases Alzheimer's disease hallmarks in neuronal cultures
Authors
Audrey Coulon, Florian Rabiller, Mari Takalo, Avishek Roy, Alexandre Pelletier, Henna Martiskainen, Dolores Siedlecki-Wullich, Nina Lannette-Weimann, Naďa Majerníková, Arthur Grenon, Vance Gao, Anaël Erhardt, Anne Pernodet, Morgane Lemaire, Floriane Limoge, Pauline Walle, Tiago Mendes, Karine Guyot, Célia Lemeu, Lukas-Iohan Carvalho, Ana Raquel Melo de Farias, Marc Hulsman, Chloé Najdek, Alejandra Freire-Regatillo, Orthis Saha, Philippe Amouyel, Camille Charbonnier, Jean-François Deleuze, Orio Dols-Icardo, Heli Jeskanen, Roosa-Maria Willman, Teemu Kuulasmaa, Mitja Kurki, John Hardy, Sami Heikkinen, Henne Holstege, Petra Mäkinen, Gaël Nicolas, Simon Mead, Michael Wagner, Alfredo Ramirez, Tuomas Rauramaa, Aarno Palotie, Rebecca Sims, Hilkka Soininen, John van Swieten, Julie Williams, Céline Bellenguez, Carla Gelle, Erwan Lambert, Marcos R Costa, Julia Tcw, Enrico Glaab, Anne-Marie Ayral, Florie Demiautte, Benjamin Grenier-Boley, Manon Muntaner, Delphine Eberlé, Séverine Deforges, Joel T Haas, Devrim Kilinc, Christophe Mulle, Julien Chapuis, Mikko Hiltunen, Julie Dumont, Jean-Charles Lambert
PLCG2 downregulation impairs synaptic function and increases Alzheimer's disease hallmarks in neuronal cultures
Annals of neurology
Published
Genetic Modifiers of ABCA1 Activity Interact with APOE Isoforms to Mediate Alzheimer's Disease Risk
Authors
Andrés Peña-Tauber, Ricardo Hernández Arriaza, Dylan Reil, Manon Muntaner, Junyoung Park, Benjamin Grenier-Boley, Marc Hulsman, Philippe Amouyel, Céline Bellenguez, Camille Charbonnier, Jean-François Deleuze, Orio Dols-Icardo, John Hardy, Henne Holstege, Gaël Nicolas, Simon Mead, Michael Wagner, Alfredo Ramirez, Rebecca Sims, John van Swieten, Julie Willams, Jean-Charles Lambert, Chaitan Khosla, Yann Le Guen, Michael D Greicius
Genetic Modifiers of ABCA1 Activity Interact with APOE Isoforms to Mediate Alzheimer's Disease Risk
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Recent Cochrane review has serious flaws: A perspective of clinicians and researchers from around the world
Authors
Heather M Snyder, Malavika P Tampi, Paul S Aisen, Ricardo Allegri, Liana G Apostolova, Alireza Atri, Sheena Aurora, Paulo Caramelli, Lucia Crivelli, Jeffrey Cummings, Bart de Strooper, Nick C Fox, Lea Tenenholz Grinberg, John Hardy, Bruce T Lamb, Allan Levey, Oscar Lopez, Catherine Mummery, Ricardo Nitrini, Sarah Pahlke, Ronald C Petersen, K Joanne Pike, Anton P Porsteinsson, Gil D Rabinovici, Michael Rafii, Rema Raman, Marwan N Sabbagh, Stephen P Salloway, Philip Scheltens, Jonathan M Schott, Dennis J Selkoe, Gustavo Sevlever, Reisa Sperling, Malu Gamez Tansey, Christopher van Dyck, Henrik Zetterberg, Maria C Carrillo
Recent Cochrane review has serious flaws: A perspective of clinicians and researchers from around the world
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Breaking barriers: Enhancing access to dementia clinical trials in the United Kingdom-Insights from the Scientific Advisory Board of the Dame Barbara Windsor Dementia Goals Programme
Authors
Ruth M McKernan, James B Rowe, Sally John, Eric Karran, Helene A Fachim, Sara Imarisio, Raj Long, Charlotte Teunissen, Sarah P Slight, Catherine Mummery, John Hardy
Breaking barriers: Enhancing access to dementia clinical trials in the United Kingdom-Insights from the Scientific Advisory Board of the Dame Barbara Windsor Dementia Goals Programme

Hardy Lab

Explore the work of the Hardy Lab, harnessing genetics to build a better understanding of dementia

 
Hardy Lab