Prof Sir John Hardy

Group Leader

Harnessing genetics to build a better understanding of dementia

Condition

Alzheimer's disease, Parkinson's disease

Topics

Genetics

Biography

Prof Sir John Hardy is a world-leading neurogeneticist in the field of neurodegenerative diseases, receiving numerous accolades that include the Breakthrough Prize in Life Sciences, the Brain Prize, election as a Fellow of the Royal Society and, in 2022, a knighthood for his contributions to science and health. In 1991, Hardy's team uncovered the first mutation directly implicated in Alzheimer's disease leading to the formulation of the highly influential 'amyloid-cascade' hypothesis. His extensive body of work in genetics will be built upon in this UK DRI programme, where the team will unravel pathogenic networks in neurodegenerative disease.

News

Key publications

Acta neuropathologica
Published
Mechanisms of increased Alzheimer's disease pathology with R47H and R62H TREM2 variants
Authors
Nurun N Fancy, Nanet Willumsen, Vicky M N Chau, Samuel L Boulger, Harry J Whitwell, Wenhao Wang, Baptiste Avot, Michael Thomas, Jonathan Talbot-Martin, Stergios Tsartsalis, Combiz Khozoie, Aisling McGarry, Eleonore Schneegans, Riad Yagoubi, To Ka Dorcas Cheung, Marianna Papageorgopoulou, Emily Adair, Benjamin Cooper, Karen Davey, Amy M Smith, William Scotton, John Hardy, Paul M Matthews, Johanna S Jackson
Mechanisms of increased Alzheimer's disease pathology with R47H and R62H TREM2 variants
bioRxiv : the preprint server for biology
Published
Non-microglial downregulation of <em>PLCG2</em> impairs synaptic function and elicits Alzheimer disease-related hallmarks
Authors
Audrey Coulon, Florian Rabiller, Mari Takalo, Avishek Roy, Alexandre Pelletier, Henna Martiskainen, Dolores Siedlecki-Wullich, Nina Lannette-Weimann, Nad'a Majerníková, Arthur Grenon, Vance Gao, Anaël Erhardt, Anne Pernodet, Morgane Lemaire, Floriane Limoge, Pauline Walle, Tiago Mendes, Karine Guyot, Célia Lemeu, Lukas-Iohan Carvalho, Ana Raquel Melo de Farias, Marc Hulsman, Chloé Najdek, Alejandra Freire-Regatillo, Orthis Saha, Philippe Amouyel, Camille Charbonnier, Jean-François Deleuze, Orio Dols-Icardo, Heli Jeskanen, Roosa-Maria Willman, Teemu Kuulasmaa, Mitja Kurki, John Hardy, Sami Heikkinen, Henne Holstege, Petra Mäkinen, Gaël Nicolas, Simon Mead, Michael Wagner, Alfredo Ramirez, Tuomas Rauramaa, Aarno Palotie, Rebecca Sims, Hilkka Soininen, John van Swieten, Julie Williams, Céline Bellenguez, Carla Gelle, Erwan Lambert, Marcos R Costa, Julia Tcw, Enrico Glaab, Anne-Marie Ayral, Florie Demiautte, Benjamin Grenier-Boley, Manon Muntaner, Delphine Eberlé, Séverine Deforges, Joel Haas, Devrim Kilinc, Christophe Mulle, Julien Chapuis, Mikko Hiltunen, Julie Dumont, Jean-Charles Lambert
Non-microglial downregulation of <em>PLCG2</em> impairs synaptic function and elicits Alzheimer disease-related hallmarks
Brain : a journal of neurology
Published
Quantitative pathology and APOE genotype reveal dementia risk and progression in Lewy body disease
Authors
Hemanth R Nelvagal, Nancy Chiraki, Toby Curless, Patrick W Cullinane, Alice Rockliffe, Samarth Pimparkar, Haruka Kawamura, Sophie Ollerenshaw, Isha Elahi, Sebastian Brandner, Lesley Wu, Raquel Real, Mina Ryten, John Hardy, Eduardo De Pablo Fernandez, Thomas T Warner, Huw R Morris, Yau Mun Lim, Zane Jaunmuktane
Quantitative pathology and APOE genotype reveal dementia risk and progression in Lewy body disease

Hardy Lab

Explore the work of the Hardy Lab, harnessing genetics to build a better understanding of dementia

 
Hardy Lab