Prof Sir John Hardy

Group Leader

Harnessing genetics to build a better understanding of dementia

Condition

Alzheimer's disease, Parkinson's disease

Topics

Genetics

Biography

Prof Sir John Hardy is a world-leading neurogeneticist in the field of neurodegenerative diseases, receiving numerous accolades that include the Breakthrough Prize in Life Sciences, the Brain Prize, election as a Fellow of the Royal Society and, in 2022, a knighthood for his contributions to science and health. In 1991, Hardy's team uncovered the first mutation directly implicated in Alzheimer's disease leading to the formulation of the highly influential 'amyloid-cascade' hypothesis. His extensive body of work in genetics will be built upon in this UK DRI programme, where the team will unravel pathogenic networks in neurodegenerative disease.

News

Key publications

Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Unravelling the plasma proteome: Pioneering biomarkers for differential dementia diagnosis
Authors
Haşim Gezegen, Merve Alaylıoğlu, Erdi Şahin, Owen Swann, Elena Veleva, Gamze Güven, Umran Yaman, Derviş A Salih, Başar Bilgiç, Haşmet Hanağası, Hakan Gürvit, Murat Emre, Duygu Gezen-Ak, Erdinç Dursun, Henrik Zetterberg, John Hardy, Amanda Heslegrave, Maryam Shoai, Bedia Samanci
Unravelling the plasma proteome: Pioneering biomarkers for differential dementia diagnosis
Molecular neurodegeneration
Published
Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer's disease through disrupted regulated intramembrane proteolysis
Authors
Oliver J Ziff, Gustavo Morrone Parfitt, Sarah Jolly, Jackie M Casey, Lucy Granat, Satinder Samra, Núria Setó-Salvia, Argyro Alatza, Leela Phadke, Benjamin Galet, Philippe Ravassard, Marie-Claude Potier, John Hardy, Dervis A Salih, Paul Whiting, Fiona Ducotterd, Rickie Patani, Selina Wray, Charles Arber
Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer's disease through disrupted regulated intramembrane proteolysis

Hardy Lab

Explore the work of the Hardy Lab, harnessing genetics to build a better understanding of dementia

 
Hardy Lab