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John Hardy

Prof Sir John Hardy

Group Leader

Harnessing genetics to build a better understanding of dementia

Biography

Prof Sir John Hardy is a world-leading neurogeneticist in the field of neurodegenerative diseases, receiving numerous accolades that include the Breakthrough Prize in Life Sciences, the Brain Prize, election as a Fellow of the Royal Society and, in 2022, a knighthood for his contributions to science and health. In 1991, Hardy's team uncovered the first mutation directly implicated in Alzheimer's disease leading to the formulation of the highly influential 'amyloid-cascade' hypothesis. His extensive body of work in genetics will be built upon in this UK DRI programme, where the team will unravel pathogenic networks in neurodegenerative disease.

News

Key publications

Brain : a journal of neurology
Published
Towards cascading genetic risk in Alzheimer's disease
Authors
Andre Altmann, Leon M Aksman, Neil P Oxtoby, Alexandra Young, ADNI, Daniel C Alexander, Frederik Barkhof, Maryam Shoai, John Hardy, Jonathan M Schott
Towards cascading genetic risk in Alzheimer's disease
EMBO J
Published
Microglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models.
Authors
Javier Rueda-Carrasco, Dimitra Sokolova, Sang-Eun Lee, Thomas Childs, Natália Jurčáková, Gerard Crowley, Sebastiaan De Schepper, Judy Z Ge, Joanne I Lachica, Christina E Toomey, Oliver J Freeman, John Hardy, Samuel J Barnes, Tammaryn Lashley, Beth Stevens, Sunghoe Chang, Soyon Hong
Microglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models.
PLoS One
Published
What does heritability of Alzheimer's disease represent?
Authors
Emily Baker, Ganna Leonenko, Karl Michael Schmidt, Matthew Hill, Amanda J Myers, Maryam Shoai, Itziar de Rojas, Niccoló Tesi, Henne Holstege, Wiesje M van der Flier, Yolande A L Pijnenburg, Agustin Ruiz, John Hardy, Sven van der Lee, Valentina Escott-Price
What does heritability of Alzheimer's disease represent?

Hardy Lab

Explore the work of the Hardy Lab, harnessing genetics to build a better understanding of dementia