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Maura Malpetti profile

Dr Maura Malpetti

Emerging Leader

Using specialist brain scans and novel blood tests to measure inflammation and accelerate the development of new treatments

Techniques

Bioinformatics, Flow cytometry, Fluid biomarkers, Human brain imaging, Statistical modelling

Biography

Dr Maura Malpetti is a Race Against Dementia Alzheimer’s Research UK Fellow and a Senior Research Associate in the Department of Clinical Neurosciences at the University of Cambridge. She originally trained in Italy for her BSc and MSc, and obtained her PhD in Clinical Neurosciences at the University of Cambridge. She further trained as a visiting researcher at the University of California San Francisco, and the Ludwig Maximilian University of Munich. Her research focusses on in vivo biomarkers for inflammation, tau and synaptic loss to investigate the pathophysiology of primary tauopathies, frontotemporal dementia, and related disorders. To this end, her lab integrates PET imaging and clinical data with fluid markers and post-mortem pathology to identify and validate early diagnostic and prognostic markers that can inform the design of new disease-modifying treatment strategies

News

Key publications

Alzheimer's research & therapy
Published
Longitudinal biomarker studies in human neuroimaging: capturing biological change of Alzheimer's pathology
Authors
Larissa Fischer, Dana Parker, Samira Maboudian, Corrina Fonseca, Claudia Tato-Fernández, Lucie Annen, Prithvi Arunachalam, Julia R Bacci, Michelle Barboure, Serena Capelli, Stamatia Karagianni, Lyduine E Collij, Paul Edison, Nick C Fox, Nicolai Franzmeier, Michel J Grothe, William J Jagust, Anne Maass, Maura Malpetti, Ross W Paterson, Aitana Sogorb-Esteve, Michael Schöll
Longitudinal biomarker studies in human neuroimaging: capturing biological change of Alzheimer's pathology
Brain : a journal of neurology
Published
Cellular signatures underlying functional resilience in presymptomatic frontotemporal dementia
Authors
Kamen A Tsvetanov, Maura Malpetti, P Simon Jones, Timothy Rittman, David J Whiteside, Alexander G Murley, Richard Bethlehem, Casey Paquola, Enrico Premi, Arabella Bouzigues, Lucy L Russell, Phoebe H Foster, Eve Ferry-Bolder, John C van Swieten, Lize C Jiskoot, Harro Seelaar, Raquel Sanchez-Valle, Robert Laforce, Caroline Graff, Daniela Galimberti, Rik Vandenberghe, Alexandre de Mendonça, Pietro Tiraboschi, Isabel Santana, Alexander Gerhard, Johannes Levin, Sandro Sorbi, Markus Otto, Maxime Bertoux, Thibaud Lebouvier, Simon Ducharme, Chris R Butler, Isabelle Le Ber, Elizabeth Finger, Maria Carmela Tartaglia, Mario Masellis, Matthis Synofzik, Fermin Moreno, Barbara Borroni, Jonathan D Rohrer, James B Rowe, Genetic FTD Initiative, GENFI
Cellular signatures underlying functional resilience in presymptomatic frontotemporal dementia
European journal of nuclear medicine and molecular imaging
Published
Comparing and combining TSPO-PET tracers in tauopathies
Authors
Harry Crook, Nicolai Franzmeier, Nesrine Rahmouni, Johannes S Gnörich, Tim D Fryer, Young T Hong, Sebastian N Roemer-Cassiano, Carla Palleis, Alexandra Strauss, P Simon Jones, Franklin I Aigbirhio, Robert Hopewell, Boris-Stephan Rauchmann, Gassan Massarweh, Robert Perneczky, Johannes Levin, Günter U Höglinger, James B Rowe, John T O'Brien, Pedro Rosa-Neto, Matthias Brendel, Maura Malpetti
Comparing and combining TSPO-PET tracers in tauopathies

Malpetti Lab

Explore the work of the Malpetti Lab, focused on investigating inflammation in people living with dementia, to accelerate the development of new treatments.

A brain with PSP dementia imaged with PET-TSPO