Maura Malpetti profile

Dr Maura Malpetti

Emerging Leader

Using specialist brain scans and novel blood tests to measure inflammation and accelerate the development of new treatments

Condition

Alzheimer's disease, Frontotemporal dementia

Topics

Immune system, Synapse & Circuitry, Biomarkers & diagnostics, Treatments & Interventions

Techniques

Bioinformatics, Flow cytometry, Fluid biomarkers, Human brain imaging, Statistical modelling

Biography

Dr Maura Malpetti is a Race Against Dementia Alzheimer’s Research UK Fellow and a Senior Research Associate in the Department of Clinical Neurosciences at the University of Cambridge. She originally trained in Italy for her BSc and MSc, and obtained her PhD in Clinical Neurosciences at the University of Cambridge. She further trained as a visiting researcher at the University of California San Francisco, and the Ludwig Maximilian University of Munich. Her research focusses on in vivo biomarkers for inflammation, tau and synaptic loss to investigate the pathophysiology of primary tauopathies, frontotemporal dementia, and related disorders. To this end, her lab integrates PET imaging and clinical data with fluid markers and post-mortem pathology to identify and validate early diagnostic and prognostic markers that can inform the design of new disease-modifying treatment strategies

News

Key publications

Brain : a journal of neurology
Published
Cortical tau deposition promotes atrophy in connected white matter regions in Alzheimer's disease
Authors
Julia Pescoller, Anna Dewenter, Amir Dehsarvi, Anna Steward, Lukas Frontzkowski, Zeyu Zhu, Sebastian N Roemer-Cassiano, Carla Palleis, Fabian Hirsch, Fabian Wagner, Hannah de Bruin, Boris Rauchmann, Robert Perneczky, Johannes Gnörich, Maura Malpetti, Rik Ossenkoppele, Michael Schöll, Johannes Levin, Günter Höglinger, Matthias Brendel, Nicolai Franzmeier
Cortical tau deposition promotes atrophy in connected white matter regions in Alzheimer's disease
Molecular psychiatry
Published
Association between FDG- and TSPO-PET signals across human and animal studies investigating neurodegenerative conditions: a systematic review
Authors
Luiza S Machado, Pedro Vidor, Lavínia Perquim, Christian Limberger, Leonardo Machado, Andréia Rocha, Carolina Soares, Nesrine Rahmouni, Wagner S Brum, Bruna Bellaver, Pamela C L Ferreira, Wyllians V Borelli, Jaderson C da Costa, Maura Malpetti, Tharick A Pascoal, Diogo O Souza, Paul Edison, Kaj Blennow, Henrik Zetterberg, Nicholas J Ashton, Andrea L Benedet, Alberto Serrano-Pozo, Pedro Rosa-Neto, Eduardo R Zimmer
Association between FDG- and TSPO-PET signals across human and animal studies investigating neurodegenerative conditions: a systematic review
Brain : a journal of neurology
Published
Connectivity as a universal predictor of tau progression in atypical Alzheimer's disease
Authors
Hannah de Bruin, Colin Groot, Henryk Barthel, Gérard N Bischof, Ganna Blazhenets, Ronald Boellaard, Baayla D C Boon, Matthias Brendel, David M Cash, William Coath, Gregory S Day, Bradford C Dickerson, Elena Doering, Alexander Drzezga, Christopher H van Dyck, Thilo van Eimeren, Wiesje M van der Flier, Carolyn A Fredericks, Tim D Fryer, Elsmarieke van de Giessen, Brian A Gordon, Jonathan Graff-Radford, Lea T Grinberg, Oskar Hansson, Diana A Hobbs, Merle C Hoenig, Günter Höglinger, David J Irwin, P Simon Jones, Keith A Josephs, Yuta Katsumi, Renaud La Joie, Edward B Lee, Johannes Levin, Maura Malpetti, Scott M McGinnis, Adam P Mecca, Rosaleena Mohanty, Ilya M Nasrallah, John T O'Brien, Ryan S O'Dell, Carla Palleis, Robert Perneczky, Jeffrey S Phillips, Deepti Putcha, Gil D Rabinovici, Nesrine Rahmouni, Pedro Rosa-Neto, James B Rowe, Michael Rullmann, Osama Sabri, Dorothee Saur, Andreas Schildan, Jonathan M Schott, Matthias L Schroeter, William W Seeley, Stijn Servaes, Irene Sintini, Ruben Smith, Salvatore Spina, Jenna Stevenson, Erik Stomrud, Olof Strandberg, Joseph Therriault, Pontus Tideman, Alexandra Touroutoglou, Anne E Trainer, Denise Visser, Fattin Wekselman, Philip S J Weston, Jennifer L Whitwell, David A Wolk, Keir Yong, Yolande A L Pijnenburg, Nicolai Franzmeier, Rik Ossenkoppele
Connectivity as a universal predictor of tau progression in atypical Alzheimer's disease

Malpetti Lab

Explore the work of the Malpetti Lab, focused on investigating inflammation in people living with dementia, to accelerate the development of new treatments.

Malpetti Lab
A brain with PSP dementia imaged with PET-TSPO