Siddharthan Chandran

Prof Siddharthan Chandran

Director & CEO

Dissecting a genetic cause of ALS and FTD and identifying ways to help protect neurons

Condition

Motor neuron disease/ALS, Frontotemporal dementia

Biography

Professor Siddharthan Chandran is Director of the UK Dementia Research Institute, and an internationally leading expert in neurodegenerative diseases. Prof Chandran is a practising neurologist and scientist working at the forefront of the emerging discipline of Regenerative Neurology, renowned for his work in motor neuron disease (MND) and MS that combines laboratory and clinical research with a particular focus on human / patient stem cells for his discovery science research. Alongside his UK DRI research, Prof Chandran is Director of the Euan MacDonald Centre for Motor Neuron Disease Research and the Anne Rowling Regenerative Neurology Clinic at the University of Edinburgh. He is also a Fellow of the Royal Society of Edinburgh and the Academy of Medical Sciences.

News

Key publications

Cell reports
Published
A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neurons
Authors
Benedikt V Hölbling, Yashica Gupta, Paolo M Marchi, Magda L Atilano, Michael Flower, Enric Ureña, Rajkumar A Goulden, Hannah K Dobbs, Eszter Katona, Alla Mikheenko, Ashling Giblin, Ali Raza Awan, Chloe L Fisher-Ward, Niamh O'Brien, Deniz Vaizoglu, Liam Kempthorne, Katherine M Wilson, Lauren M Gittings, Mireia Carcolé, Marc-David Ruepp, Sarah Mizielinska, Linda Partridge, Pietro Fratta, Sarah J Tabrizi, Bhuvaneish T Selvaraj, Siddharthan Chandran, Emma Armstrong, Paul Whiting, Adrian M Isaacs
A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neurons
Glia
Published
The Fragile X Messenger Ribonucleoprotein 1 Regulates the Morphology and Maturation of Human and Rat Oligodendrocytes
Authors
Vidya Ramesh, Eleni Tsoukala, Ioanna Kougianou, Zrinko Kozic, Karen Burr, Biju Viswanath, David Hampton, David Story, Bharath Kumar Reddy, Rakhi Pal, Owen Dando, Peter C Kind, Sumantra Chattarji, Bhuvaneish T Selvaraj, Siddharthan Chandran, Lida Zoupi
The Fragile X Messenger Ribonucleoprotein 1 Regulates the Morphology and Maturation of Human and Rat Oligodendrocytes
Brain : a journal of neurology
Published
C21ORF2 mutations point towards primary cilia dysfunction in amyotrophic lateral sclerosis
Authors
Mathias De Decker, Pavol Zelina, Thomas G Moens, Jimmy Beckers, Matilde Contardo, Katarina Stoklund Dittlau, Evelien Van Schoor, Alicja Ronisz, Kristel Eggermont, Matthieu Moisse, Siddharthan Chandran, Jan H Veldink, Dietmar Rudolf Thal, Ludo Van Den Bosch, R Jeroen Pasterkamp, Philip Van Damme
C21ORF2 mutations point towards primary cilia dysfunction in amyotrophic lateral sclerosis

Chandran Lab

Explore the work of the Chandran Lab, Dissecting a genetic cause of ALS and FTD and identifying ways to help protect neurons.

 
Chandran Lab
Human stem cell-derived myelinating oligodendrocyte can be seen with many myelinating processes wrapped around unstained neurons