Publications

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Jan 28, 2026 - Research

Targeting the gut's immune system could tackle early stages of Parkinson's

New research, led by Dr Soyon Hong and Dr Tim Bartels at the UK DRI at UCL, has revealed how Parkinson’s spreads from the gut...

Learn more Targeting the gut's immune system could tackle early stages of Parkinson's

Cytokines released by T cells after encountering cancer cells

Jan 23, 2026

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system

Jan 14, 2026 - Research

Brain shrinkage and inflammation predict disease progression in progressive supranuclear palsy

New research led by Dr Maura Malpetti and Noah Shapiro (UK DRI at Cambridge) reveals signs of brain shrinkage, inflammation and blood markers for nerve...

Learn more Brain shrinkage and inflammation predict disease progression in progressive supranuclear palsy

Lancet Neurol

Published Aug 19, 2013

Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration.

Authors

Joanna M Wardlaw, Eric E Smith, Geert J Biessels, Charlotte Cordonnier, Franz Fazekas, Richard Frayne, Richard I Lindley, John T O'Brien, Frederik Barkhof, Oscar R Benavente, Sandra E Black, Carol Brayne, Monique Breteler, Hugues Chabriat, Charles Decarli, Frank-Erik de Leeuw, Fergus Doubal, Marco Duering, Nick C Fox, Steven Greenberg, Vladimir Hachinski, Ingo Kilimann, Vincent Mok, Robert van Oostenbrugge, Leonardo Pantoni, Oliver Speck, Blossom C M Stephan, Stefan Teipel, Anand Viswanathan, David Werring, Christopher Chen, Colin Smith, Mark van Buchem, Bo Norrving, Philip B Gorelick, Martin Dichgans

Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration.

Nat Neurosci

Published Jul 21, 2013

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination.

Authors

Veronique E Miron, Amanda Boyd, Jing-Wei Zhao, Tracy J Yuen, Julia M Ruckh, Jennifer L Shadrach, Peter van Wijngaarden, Amy J Wagers, Anna Williams, Robin J M Franklin, Charles Ffrench-Constant

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination.

Brain

Published Jul 18, 2013

The role of the posterior cingulate cortex in cognition and disease.

Authors

Robert Leech, David J Sharp

The role of the posterior cingulate cortex in cognition and disease.

Nature Protocols

Published Jun 20, 2013

Studying synapses in human brain with array tomography and electron microscopy

Authors

Kevin R Kay, Colin Smith, Ann K Wright, Alberto Serrano-Pozo, Amy M Pooler, Robert Koffie, Mark E Bastin, Thomas H Bak, Sharon Abrahams, Katherine J Kopeikina, Declan McGuone, Matthew P Frosch, Thomas H Gillingwater, Bradley T Hyman, Tara L Spires-Jones

Studying synapses in human brain with array tomography and electron microscopy

Brain

Published May 25, 2013

Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β

Authors

Robert M. Koffie, Tadafumi Hashimoto, Hwan-Ching Tai, Kevin R. Kay, Alberto Serrano-Pozo, Daniel Joyner, Steven Hou, Katherine J. Kopeikina, Matthew P. Frosch, Virginia M. Lee, David M. Holtzman, Bradley T. Hyman, Tara L. Spires-Jones

Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β

Nat Commun

Published May 21, 2013

Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation.

Authors

Luke C Davies, Marcela Rosas, Stephen J Jenkins, Chia-Te Liao, Martin J Scurr, Frank Brombacher, Donald J Fraser, Judith E Allen, Simon A Jones, Philip R Taylor

Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation.

J Cell Biol

Published Apr 15, 2013

Lifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redox.

Authors

Edward Avezov, Benedict C S Cross, Gabriele S Kaminski Schierle, Mikael Winters, Heather P Harding, Eduardo Pinho Melo, Clemens F Kaminski, David Ron

Lifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redox.

J Biol Chem

Published Jan 18, 2013

Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons.

Authors

Jessica W Wu, Mathieu Herman, Li Liu, Sabrina Simoes, Christopher M Acker, Helen Figueroa, Joshua I Steinberg, Martin Margittai, Rakez Kayed, Chiara Zurzolo, Gilbert Di Paolo, Karen E Duff

Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons.

Nat Protoc

Published Jan 14, 2013

Studying synapses in human brain with array tomography and electron microscopy.

Authors

Studying synapses in human brain with array tomography and electron microscopy.

N Engl J Med

Published Jan 10, 2013

TREM2 variants in Alzheimer's disease.

Authors

Rita Guerreiro, Aleksandra Wojtas, Jose Bras, Minerva Carrasquillo, Ekaterina Rogaeva, Elisa Majounie, Carlos Cruchaga, Celeste Sassi, John S K Kauwe, Steven Younkin, Lilinaz Hazrati, John Collinge, Jennifer Pocock, Tammaryn Lashley, Julie Williams, Jean-Charles Lambert, Philippe Amouyel, Alison Goate, Rosa Rademakers, Kevin Morgan, John Powell, Peter St George-Hyslop, Andrew Singleton, John Hardy,

TREM2 variants in Alzheimer's disease.

N Engl J Med

Published Jan 10, 2013

TREM2 variants in Alzheimer's disease.

Authors

TREM2 variants in Alzheimer's disease.

Neurobiol Dis

Published Dec 30, 2012

Astrocyte-specific IKK2 activation in mice is sufficient to induce neuroinflammation but does not increase susceptibility to MPTP.

Authors

Patrick Oeckl, Michael Lattke, Thomas Wirth, Bernd Baumann, Boris Ferger

Astrocyte-specific IKK2 activation in mice is sufficient to induce neuroinflammation but does not increase susceptibility to MPTP.

Nature

Published Dec 13, 2012

Ubiquitin chain conformation regulates recognition and activity of interacting proteins.

Authors

Yu Ye, Georg Blaser, Mathew H Horrocks, Maria J Ruedas-Rama, Shehu Ibrahim, Alexander A Zhukov, Angel Orte, David Klenerman, Sophie E Jackson, David Komander

Ubiquitin chain conformation regulates recognition and activity of interacting proteins.

Nature

Published Dec 13, 2012

Ubiquitin chain conformation regulates recognition and activity of interacting proteins.

Authors

Yu Ye, Georg Blaser, Mathew H Horrocks, Maria J Ruedas-Rama, Shehu Ibrahim, Alexander A Zhukov, Angel Orte, David Klenerman, Sophie E Jackson, David Komander

Ubiquitin chain conformation regulates recognition and activity of interacting proteins.

J Neurosci

Published Aug 22, 2012

Nuclear factor κB activation impairs ependymal ciliogenesis and links neuroinflammation to hydrocephalus formation.

Authors

Michael Lattke, Alexander Magnutzki, Paul Walther, Thomas Wirth, Bernd Baumann

Nuclear factor κB activation impairs ependymal ciliogenesis and links neuroinflammation to hydrocephalus formation.

Hum Mol Genet

Published Aug 01, 2012

Disease severity in a mouse model of ataxia telangiectasia is modulated by the DNA damage checkpoint gene Hus1.

Authors

Gabriel Balmus, Min Zhu, Sucheta Mukherjee, Amy M Lyndaker, Kelly R Hume, Jaesung Lee, Mark L Riccio, Anthony P Reeves, Nathan B Sutter, Drew M Noden, Rachel M Peters, Robert S Weiss

Disease severity in a mouse model of ataxia telangiectasia is modulated by the DNA damage checkpoint gene Hus1.

Hum Mol Genet

Published Aug 01, 2012

Disease severity in a mouse model of ataxia telangiectasia is modulated by the DNA damage checkpoint gene Hus1.

Authors

Gabriel Balmus, Min Zhu, Sucheta Mukherjee, Amy M Lyndaker, Kelly R Hume, Jaesung Lee, Mark L Riccio, Anthony P Reeves, Nathan B Sutter, Drew M Noden, Rachel M Peters, Robert S Weiss

Disease severity in a mouse model of ataxia telangiectasia is modulated by the DNA damage checkpoint gene Hus1.

Brain

Published Jul 13, 2012

Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β.

Authors

Robert M Koffie, Tadafumi Hashimoto, Hwan-Ching Tai, Kevin R Kay, Alberto Serrano-Pozo, Daniel Joyner, Steven Hou, Katherine J Kopeikina, Matthew P Frosch, Virginia M Lee, David M Holtzman, Bradley T Hyman, Tara L Spires-Jones

Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β.