Publications

Featured

Oct 31, 2024 - Research

Glaucoma drug shows promise against neurodegenerative diseases, animal studies suggest

A drug commonly used to treat glaucoma has been shown in zebrafish and mice to protect against the build-up in the brain of the protein...

Learn more Glaucoma drug shows promise against neurodegenerative diseases, animal studies suggest

Two people sit in wheelchairs next to one another

Sep 19, 2024 - Research

First results published from innovative platform trial, MND-SMART, aiming to speed up delivery of treatments for motor neuron disease

The first results from the innovative platform trial, MND-SMART, have been published in the journal The Lancet Neurology today. Led by Prof Siddharthan Chandran (UK...

Learn more First results published from innovative platform trial, MND-SMART, aiming to speed up delivery of treatments for motor neuron disease

Illustration of the inside of a blood vessel

Sep 18, 2024 - Research

Effects of reduced blood flow in early Alzheimer’s reversed by repurposed drug

A new mouse study led by Prof David Attwell (BHF-UK DRI Centre for Vascular Dementia Research) has found that a repurposed drug could reverse the...

Learn more Effects of reduced blood flow in early Alzheimer’s reversed by repurposed drug

Neuron

Published Nov 15, 2017

Deprivation-Induced Homeostatic Spine Scaling In Vivo Is Localized to Dendritic Branches that Have Undergone Recent Spine Loss.

Authors

Samuel J Barnes, Eleonora Franzoni, R Irene Jacobsen, Ferenc Erdelyi, Gabor Szabo, Claudia Clopath, Georg B Keller, Tara Keck

Deprivation-Induced Homeostatic Spine Scaling In Vivo Is Localized to Dendritic Branches that Have Undergone Recent Spine Loss.

J Neurosci

Published Sep 13, 2017

Individual Movement Variability Magnitudes Are Explained by Cortical Neural Variability.

Authors

Shlomi Haar, Opher Donchin, Ilan Dinstein

Individual Movement Variability Magnitudes Are Explained by Cortical Neural Variability.

Elife

Published Sep 12, 2017

A genomic lifespan program that reorganises the young adult brain is targeted in schizophrenia.

Authors

Nathan G Skene, Marcia Roy, Seth Gn Grant

A genomic lifespan program that reorganises the young adult brain is targeted in schizophrenia.

Nat Commun

Published Aug 18, 2017

Corrigendum: Adrenergic-mediated loss of splenic marginal zone B cells contributes to infection susceptibility after stroke.

Authors

Laura McCulloch, Craig J Smith, Barry W McColl

Corrigendum: Adrenergic-mediated loss of splenic marginal zone B cells contributes to infection susceptibility after stroke.

Neuron

Published Aug 02, 2017

Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence.

Authors

Hua Chai, Blanca Diaz-Castro, Eiji Shigetomi, Emma Monte, J Christopher Octeau, Xinzhu Yu, Whitaker Cohn, Pradeep S Rajendran, Thomas M Vondriska, Julian P Whitelegge, Giovanni Coppola, Baljit S Khakh

Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence.

Cell

Published Jul 27, 2017

Alzheimer's-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions.

Authors

Maria Szaruga, Bogdan Munteanu, Sam Lismont, Sarah Veugelen, Katrien Horré, Marc Mercken, Takaomi C Saido, Natalie S Ryan, Tatjana De Vos, Savvas N Savvides, Rodrigo Gallardo, Joost Schymkowitz, Frederic Rousseau, Nick C Fox, Carsten Hopf, Bart De Strooper, Lucía Chávez-Gutiérrez

Alzheimer's-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions.

Elife

Published Jul 21, 2017

Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1.

Authors

Jamie McQueen, Tomás J Ryan, Sean McKay, Katie Marwick, Paul Baxter, Sarah M Carpanini, Thomas M Wishart, Thomas H Gillingwater, Jean C Manson, David J A Wyllie, Seth G N Grant, Barry W McColl, Noboru H Komiyama, Giles E Hardingham

Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1.

Cell

Published Jun 01, 2017

Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields.

Authors

Nir Grossman, David Bono, Nina Dedic, Suhasa B Kodandaramaiah, Andrii Rudenko, Ho-Jun Suk, Antonino M Cassara, Esra Neufeld, Niels Kuster, Li-Huei Tsai, Alvaro Pascual-Leone, Edward S Boyden

Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields.

Sci Transl Med

Published May 31, 2017

Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice.

Authors

Qiaoqiao Shi, Saba Chowdhury, Rong Ma, Kevin X Le, Soyon Hong, Barbara J Caldarone, Beth Stevens, Cynthia A Lemere

Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice.

Nature

Published May 04, 2017

Polyglutamine tracts regulate beclin 1-dependent autophagy.

Authors

Avraham Ashkenazi, Carla F Bento, Thomas Ricketts, Mariella Vicinanza, Farah Siddiqi, Mariana Pavel, Ferdinando Squitieri, Maarten C Hardenberg, Sara Imarisio, Fiona M Menzies, David C Rubinsztein

Polyglutamine tracts regulate beclin 1-dependent autophagy.

Sci Transl Med

Published May 03, 2017

Mutations in the vesicular trafficking protein annexin A11 are associated with amyotrophic lateral sclerosis.

Authors

Bradley N Smith, Simon D Topp, Claudia Fallini, Hideki Shibata, Han-Jou Chen, Claire Troakes, Andrew King, Nicola Ticozzi, Kevin P Kenna, Athina Soragia-Gkazi, Jack W Miller, Akane Sato, Diana Marques Dias, Maryangel Jeon, Caroline Vance, Chun Hao Wong, Martina de Majo, Wejdan Kattuah, Jacqueline C Mitchell, Emma L Scotter, Nicholas W Parkin, Peter C Sapp, Matthew Nolan, Peter J Nestor, Michael Simpson, Michael Weale, Monkel Lek, Frank Baas, J M Vianney de Jong, Anneloor L M A Ten Asbroek, Alberto Garcia Redondo, Jesús Esteban-Pérez, Cinzia Tiloca, Federico Verde, Stefano Duga, Nigel Leigh, Hardev Pall, Karen E Morrison, Ammar Al-Chalabi, Pamela J Shaw, Janine Kirby, Martin R Turner, Kevin Talbot, Orla Hardiman, Jonathan D Glass, Jacqueline De Belleroche, Masatoshi Maki, Stephen E Moss, Christopher Miller, Cinzia Gellera, Antonia Ratti, Safa Al-Sarraj, Robert H Brown, Vincenzo Silani, John E Landers, Christopher E Shaw

Mutations in the vesicular trafficking protein annexin A11 are associated with amyotrophic lateral sclerosis.

Nat Commun

Published May 02, 2017

Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism.

Authors

Philip Hasel, Owen Dando, Zoeb Jiwaji, Paul Baxter, Alison C Todd, Samuel Heron, Nóra M Márkus, Jamie McQueen, David W Hampton, Megan Torvell, Sachin S Tiwari, Sean McKay, Abel Eraso-Pichot, Antonio Zorzano, Roser Masgrau, Elena Galea, Siddharthan Chandran, David J A Wyllie, T Ian Simpson, Giles E Hardingham

Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism.

J Exp Med

Published May 01, 2017

Detection of interferon alpha protein reveals differential levels and cellular sources in disease.

Authors

Mathieu P Rodero, Jérémie Decalf, Vincent Bondet, David Hunt, Gillian I Rice, Scott Werneke, Sarah L McGlasson, Marie-Alexandra Alyanakian, Brigitte Bader-Meunier, Christine Barnerias, Nathalia Bellon, Alexandre Belot, Christine Bodemer, Tracy A Briggs, Isabelle Desguerre, Marie-Louise Frémond, Marie Hully, Arn M J M van den Maagdenberg, Isabelle Melki, Isabelle Meyts, Lucile Musset, Nadine Pelzer, Pierre Quartier, Gisela M Terwindt, Joanna Wardlaw, Stewart Wiseman, Frédéric Rieux-Laucat, Yoann Rose, Bénédicte Neven, Christina Hertel, Adrian Hayday, Matthew L Albert, Flore Rozenberg, Yanick J Crow, Darragh Duffy

Detection of interferon alpha protein reveals differential levels and cellular sources in disease.

Acta Neuropathol Commun

Published Apr 18, 2017

Bidirectional nucleolar dysfunction in C9orf72 frontotemporal lobar degeneration.

Authors

Sarah Mizielinska, Charlotte E Ridler, Rubika Balendra, Annora Thoeng, Nathan S Woodling, Friedrich A Grässer, Vincent Plagnol, Tammaryn Lashley, Linda Partridge, Adrian M Isaacs

Bidirectional nucleolar dysfunction in C9orf72 frontotemporal lobar degeneration.

BMC Biol

Published Mar 27, 2017

TriPer, an optical probe tuned to the endoplasmic reticulum tracks changes in luminal H2O2.

Authors

Eduardo Pinho Melo, Carlos Lopes, Peter Gollwitzer, Stephan Lortz, Sigurd Lenzen, Ilir Mehmeti, Clemens F Kaminski, David Ron, Edward Avezov

TriPer, an optical probe tuned to the endoplasmic reticulum tracks changes in luminal H2O2.

Neuron

Published Mar 22, 2017

Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling.

Authors

Marco Brancaccio, Andrew P Patton, Johanna E Chesham, Elizabeth S Maywood, Michael H Hastings

Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling.

Neuron

Published Mar 08, 2017

Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain.

Authors

Ira Espuny-Camacho, Amaia M Arranz, Mark Fiers, An Snellinx, Kunie Ando, Sebastian Munck, Jerome Bonnefont, Laurie Lambot, Nikky Corthout, Lorna Omodho, Elke Vanden Eynden, Enrico Radaelli, Ina Tesseur, Selina Wray, Andreas Ebneth, John Hardy, Karelle Leroy, Jean-Pierre Brion, Pierre Vanderhaeghen, Bart De Strooper

Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain.

Neuron

Published Feb 08, 2017

Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer's Disease.

Authors

Hongjun Fu, Gustavo A Rodriguez, Mathieu Herman, Sheina Emrani, Eden Nahmani, Geoffrey Barrett, Helen Y Figueroa, Eliana Goldberg, S Abid Hussaini, Karen E Duff

Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer's Disease.

Shaping the future of dementia research: Meet the UK DRI’s newest Emerging Leaders

Why partner with the UK DRI?

Why join the UK DRI?

Publications

Featured

Glaucoma drug shows promise against neurodegenerative diseases, animal studies suggest

First results published from innovative platform trial, MND-SMART, aiming to speed up delivery of treatments for motor neuron disease

Effects of reduced blood flow in early Alzheimer’s reversed by repurposed drug

Deprivation-Induced Homeostatic Spine Scaling In Vivo Is Localized to Dendritic Branches that Have Undergone Recent Spine Loss.

Individual Movement Variability Magnitudes Are Explained by Cortical Neural Variability.

A genomic lifespan program that reorganises the young adult brain is targeted in schizophrenia.

Corrigendum: Adrenergic-mediated loss of splenic marginal zone B cells contributes to infection susceptibility after stroke.

Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence.

Alzheimer's-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions.

Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1.

Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields.

Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice.

Polyglutamine tracts regulate beclin 1-dependent autophagy.

Mutations in the vesicular trafficking protein annexin A11 are associated with amyotrophic lateral sclerosis.

Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism.

Detection of interferon alpha protein reveals differential levels and cellular sources in disease.

Bidirectional nucleolar dysfunction in C9orf72 frontotemporal lobar degeneration.

TriPer, an optical probe tuned to the endoplasmic reticulum tracks changes in luminal H2O2.

Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling.

Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain.

Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer's Disease.