Publications

Featured

Oct 31, 2024 - Research

Glaucoma drug shows promise against neurodegenerative diseases, animal studies suggest

A drug commonly used to treat glaucoma has been shown in zebrafish and mice to protect against the build-up in the brain of the protein...

Learn more Glaucoma drug shows promise against neurodegenerative diseases, animal studies suggest

Two people sit in wheelchairs next to one another

Sep 19, 2024 - Research

First results published from innovative platform trial, MND-SMART, aiming to speed up delivery of treatments for motor neuron disease

The first results from the innovative platform trial, MND-SMART, have been published in the journal The Lancet Neurology today. Led by Prof Siddharthan Chandran (UK...

Learn more First results published from innovative platform trial, MND-SMART, aiming to speed up delivery of treatments for motor neuron disease

Illustration of the inside of a blood vessel

Sep 18, 2024 - Research

Effects of reduced blood flow in early Alzheimer’s reversed by repurposed drug

A new mouse study led by Prof David Attwell (BHF-UK DRI Centre for Vascular Dementia Research) has found that a repurposed drug could reverse the...

Learn more Effects of reduced blood flow in early Alzheimer’s reversed by repurposed drug

Nature

Published Feb 12, 2015

Grid cell symmetry is shaped by environmental geometry.

Authors

Julija Krupic, Marius Bauza, Stephen Burton, Caswell Barry, John O'Keefe

Grid cell symmetry is shaped by environmental geometry.

BMC Biol

Published Jan 10, 2015

Retarded PDI diffusion and a reductive shift in poise of the calcium depleted endoplasmic reticulum.

Authors

Edward Avezov, Tasuku Konno, Alisa Zyryanova, Weiyue Chen, Romain Laine, Ana Crespillo-Casado, Eduardo Pinho Melo, Ryo Ushioda, Kazuhiro Nagata, Clemens F Kaminski, Heather P Harding, David Ron

Retarded PDI diffusion and a reductive shift in poise of the calcium depleted endoplasmic reticulum.

J Neurosci

Published Nov 12, 2014

Network-mediated encoding of circadian time: the suprachiasmatic nucleus (SCN) from genes to neurons to circuits, and back.

Authors

Marco Brancaccio, Ryosuke Enoki, Cristina N Mazuski, Jeff Jones, Jennifer A Evans, Abdelhalim Azzi

Network-mediated encoding of circadian time: the suprachiasmatic nucleus (SCN) from genes to neurons to circuits, and back.

Cell

Published Nov 06, 2014

Lessons from a failed γ-secretase Alzheimer trial.

Authors

Bart De Strooper

Lessons from a failed γ-secretase Alzheimer trial.

Science

Published Sep 05, 2014

C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins.

Authors

Sarah Mizielinska, Sebastian Grönke, Teresa Niccoli, Charlotte E Ridler, Emma L Clayton, Anny Devoy, Thomas Moens, Frances E Norona, Ione O C Woollacott, Julian Pietrzyk, Karen Cleverley, Andrew J Nicoll, Stuart Pickering-Brown, Jacqueline Dols, Melissa Cabecinha, Oliver Hendrich, Pietro Fratta, Elizabeth M C Fisher, Linda Partridge, Adrian M Isaacs

C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins.

Science

Published Aug 01, 2014

Interneurons. Fast-spiking, parvalbumin⁺ GABAergic interneurons: from cellular design to microcircuit function.

Authors

Hua Hu, Jian Gan, Peter Jonas

Interneurons. Fast-spiking, parvalbumin⁺ GABAergic interneurons: from cellular design to microcircuit function.

Neuron

Published May 21, 2014

The intersection of amyloid beta and tau at synapses in Alzheimer's disease.

Authors

Tara L Spires-Jones, Bradley T Hyman

The intersection of amyloid beta and tau at synapses in Alzheimer's disease.

Science

Published May 09, 2014

The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal.

Authors

Marcela Rosas, Luke C Davies, Peter J Giles, Chia-Te Liao, Bashar Kharfan, Timothy C Stone, Valerie B O'Donnell, Donald J Fraser, Simon A Jones, Philip R Taylor

The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal.

Neuron

Published Apr 16, 2014

Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes.

Authors

Soyon Hong, Beth L Ostaszewski, Ting Yang, Tiernan T O'Malley, Ming Jin, Katsuhiko Yanagisawa, Shaomin Li, Tim Bartels, Dennis J Selkoe

Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes.

Science

Published Apr 11, 2014

PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling.

Authors

Vanessa A Morais, Dominik Haddad, Katleen Craessaerts, Pieter-Jan De Bock, Jef Swerts, Sven Vilain, Liesbeth Aerts, Lut Overbergh, Anne Grünewald, Philip Seibler, Christine Klein, Kris Gevaert, Patrik Verstreken, Bart De Strooper

PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling.

Nature

Published Apr 03, 2014

Capillary pericytes regulate cerebral blood flow in health and disease.

Authors

Catherine N Hall, Clare Reynell, Bodil Gesslein, Nicola B Hamilton, Anusha Mishra, Brad A Sutherland, Fergus M O'Farrell, Alastair M Buchan, Martin Lauritzen, David Attwell

Capillary pericytes regulate cerebral blood flow in health and disease.

N Engl J Med

Published Mar 27, 2014

Thrombotic microangiopathy associated with interferon beta.

Authors

David Hunt, David Kavanagh, Iain Drummond, Belinda Weller, Chris Bellamy, James Overell, Stephen Evans, Andrew Jackson, Siddharthan Chandran

Thrombotic microangiopathy associated with interferon beta.

Philos Trans R Soc Lond B Biol Sci

Published Feb 05, 2014

How environment geometry affects grid cell symmetry and what we can learn from it.

Authors

Julija Krupic, Marius Bauza, Stephen Burton, Colin Lever, John O'Keefe

How environment geometry affects grid cell symmetry and what we can learn from it.

N Engl J Med

Published Jan 23, 2014

Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.

Authors

Stephen Salloway, Reisa Sperling, Nick C Fox, Kaj Blennow, William Klunk, Murray Raskind, Marwan Sabbagh, Lawrence S Honig, Anton P Porsteinsson, Steven Ferris, Marcel Reichert, Nzeera Ketter, Bijan Nejadnik, Volkmar Guenzler, Maja Miloslavsky, Daniel Wang, Yuan Lu, Julia Lull, Iulia Cristina Tudor, Enchi Liu, Michael Grundman, Eric Yuen, Ronald Black, H Robert Brashear,

Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.

J Cell Biol

Published Apr 15, 2013

Lifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redox.

Authors

Edward Avezov, Benedict C S Cross, Gabriele S Kaminski Schierle, Mikael Winters, Heather P Harding, Eduardo Pinho Melo, Clemens F Kaminski, David Ron

Lifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redox.

N Engl J Med

Published Jan 10, 2013

TREM2 variants in Alzheimer's disease.

Authors

Rita Guerreiro, Aleksandra Wojtas, Jose Bras, Minerva Carrasquillo, Ekaterina Rogaeva, Elisa Majounie, Carlos Cruchaga, Celeste Sassi, John S K Kauwe, Steven Younkin, Lilinaz Hazrati, John Collinge, Jennifer Pocock, Tammaryn Lashley, Julie Williams, Jean-Charles Lambert, Philippe Amouyel, Alison Goate, Rosa Rademakers, Kevin Morgan, John Powell, Peter St George-Hyslop, Andrew Singleton, John Hardy,

TREM2 variants in Alzheimer's disease.

Nature

Published Dec 13, 2012

Ubiquitin chain conformation regulates recognition and activity of interacting proteins.

Authors

Yu Ye, Georg Blaser, Mathew H Horrocks, Maria J Ruedas-Rama, Shehu Ibrahim, Alexander A Zhukov, Angel Orte, David Klenerman, Sophie E Jackson, David Komander

Ubiquitin chain conformation regulates recognition and activity of interacting proteins.

Hum Mol Genet

Published Aug 01, 2012

Disease severity in a mouse model of ataxia telangiectasia is modulated by the DNA damage checkpoint gene Hus1.

Authors

Gabriel Balmus, Min Zhu, Sucheta Mukherjee, Amy M Lyndaker, Kelly R Hume, Jaesung Lee, Mark L Riccio, Anthony P Reeves, Nathan B Sutter, Drew M Noden, Rachel M Peters, Robert S Weiss

Disease severity in a mouse model of ataxia telangiectasia is modulated by the DNA damage checkpoint gene Hus1.

Shaping the future of dementia research: Meet the UK DRI’s newest Emerging Leaders

Why partner with the UK DRI?

Why join the UK DRI?

Publications

Featured

Glaucoma drug shows promise against neurodegenerative diseases, animal studies suggest

First results published from innovative platform trial, MND-SMART, aiming to speed up delivery of treatments for motor neuron disease

Effects of reduced blood flow in early Alzheimer’s reversed by repurposed drug

Grid cell symmetry is shaped by environmental geometry.

Retarded PDI diffusion and a reductive shift in poise of the calcium depleted endoplasmic reticulum.

Network-mediated encoding of circadian time: the suprachiasmatic nucleus (SCN) from genes to neurons to circuits, and back.

Lessons from a failed γ-secretase Alzheimer trial.

C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins.

Interneurons. Fast-spiking, parvalbumin⁺ GABAergic interneurons: from cellular design to microcircuit function.

The intersection of amyloid beta and tau at synapses in Alzheimer's disease.

The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal.

Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes.

PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling.

Capillary pericytes regulate cerebral blood flow in health and disease.

Thrombotic microangiopathy associated with interferon beta.

How environment geometry affects grid cell symmetry and what we can learn from it.

Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.

Lifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redox.

TREM2 variants in Alzheimer's disease.

Ubiquitin chain conformation regulates recognition and activity of interacting proteins.

Disease severity in a mouse model of ataxia telangiectasia is modulated by the DNA damage checkpoint gene Hus1.