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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Nature neuroscience
Published

Tau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex

Authors
Rik Ossenkoppele, Emma M Coomans, Liana G Apostolova, Suzanne L Baker, Henryk Barthel, Thomas G Beach, Tammy L S Benzinger, Tobey Betthauser, Gérard N Bischof, Michel Bottlaender, Pierick Bourgeat, Anouk den Braber, Matthias Brendel, Adam M Brickman, David M Cash, Maria C Carrillo, William Coath, Bradley T Christian, Brad C Dickerson, Vincent Dore, Alexander Drzezga, Azadeh Feizpour, Wiesje M van der Flier, Nicolai Franzmeier, Giovanni B Frisoni, Valentina Garibotto, Elsmarieke van de Giessen, Juan Domingo-Gispert, Johannes Gnoerich, Yuna Gu, Yihui Guan, Bernard J Hanseeuw, Theresa M Harrison, Clifford R Jack, Elena Jaeger, William J Jagust, Willemijn J Jansen, Renaud La Joie, Keith A Johnson, Sterling C Johnson, Ian A Kennedy, Jun Pyo Kim, Koen van Laere, Julien Lagarde, Patrick Lao, José A Luchsinger, Silke Kern, William C Kreisl, Vincent Malotaux, Maura Malpetti, Jennifer J Manly, Xiaoxie Mao, Niklas Mattsson-Carlgren, Mayo Clinic Study on Aging, Konstantin Messerschmidt, Carolina Minguillon, Elizabeth M Mormino, John T O'Brien, Sebastian Palmqvist, Debora E Peretti, Ron C Petersen, Yolande A L Pijnenburg, Michael J Pontecorvo, Judes Poirier, PREVENT-AD Research Group, Gil D Rabinovici, Nesrine Rahmouni, Shannon L Risacher, Pedro Rosa-Neto, Howard Rosen, Christopher C Rowe, James B Rowe, Michael Rullmann, Yasmine Salman, Marie Sarazin, Andrew J Saykin, Julie A Schneider, Michael Schöll, Jonathan M Schott, Sang Won Seo, Geidy E Serrano, Sergey Shcherbinin, Mahnaz Shekari, Ingmar Skoog, Ruben Smith, Reisa A Sperling, Laure Spruyt, Erik Stomrud, Olof Strandberg, Joseph Therriault, Fang Xie, Rik Vandenberghe, Victor L Villemagne, Sylvia Villeneuve, Pieter Jelle Visser, Hillary Vossler, Christina B Young, Colin Groot, Oskar Hansson
Tau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Identifying subphenotypes of patients undergoing post-operative delirium assessment

Authors
Emily Margaret Louise Bowman, Daniel F McAuley, Bernadette McGuinness, Anthony P Passmore, David Beverland, Henrik Zetterberg, Jonathan M Schott, Amanda Heslegrave, Elena Veleva, Rhiannon Laban, Aoife Sweeney, Emma L Cunningham
Identifying subphenotypes of patients undergoing post-operative delirium assessment
Nature neuroscience
Published

Evidence for trans-synaptic propagation of oligomeric tau in human progressive supranuclear palsy

Authors
Robert I McGeachan, Lois Keavey, Elizabeth M Simzer, Ya Yin Chang, Jamie L Rose, Maxwell P Spires-Jones, Mollie Gilmore, Kristjan Holt, Soraya Meftah, Natalia Ravingerova, Cristina Scutariu, Lewis W Taylor, Declan King, Makis Tzioras, Jane Tulloch, Sam A Booker, Imran Liaquat, Nicole Hindley-Pollock, Bethany Geary, Colin Smith, Paul M Brennan, Claire S Durrant, Tara L Spires-Jones
Evidence for trans-synaptic propagation of oligomeric tau in human progressive supranuclear palsy
The Journal of clinical investigation
Published

Organ-specific features of human kidney lymphatics are disrupted in chronic transplant rejection

Authors
Daniyal J Jafree, Benjamin J Stewart, Karen L Price, Maria Kolatsi-Joannou, Camille Laroche, Barian Mohidin, Benjamin Davis, Hannah Mitchell, Lauren G Russell, Lucía Marinas Del Rey, Chun Jing Wang, William J Mason, Byung Il Lee, Lauren Heptinstall, Ayshwarya Subramanian, Gideon Pomeranz, Dale Moulding, Laura Wilson, Tahmina Wickenden, Saif N Malik, Natalie Holroyd, Claire L Walsh, Jennifer C Chandler, Kevin X Cao, Paul Jd Winyard, Adrian S Woolf, Marc Aurel Busche, Simon Walker-Samuel, Lucy Sk Walker, Tessa Crompton, Peter J Scambler, Reza Motallebzadeh, Menna R Clatworthy, David A Long
Organ-specific features of human kidney lymphatics are disrupted in chronic transplant rejection
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Regional effects of gantenerumab on neuroimaging biomarkers in the DIAN-TU-001 trial

Authors
Austin McCullough, Charles D Chen, Brian A Gordon, Nelly Joseph-Mathurin, Clifford R Jack, Robert Koeppe, Russ Hornbeck, Deborah Koudelis, Nicole S McKay, Diana A Hobbs, Shaney Flores, Sarah J Keefe, Neelum T Aggarwal, Ricardo F Allegri, Sarah B Berman, Thomas Bird, Sandra E Black, William S Brooks, Jasmeer P Chhatwal, Gregory S Day, Martin R Farlow, Nick C Fox, Serge Gauthier, Lawrence S Honig, Ging-Yuek Hsiung, Mathias Jucker, Johannes Levin, Mario Masellis, Colin Masters, Patricio Chrem Mendez, John M Ringman, B Joy Snider, Stephen Salloway, Peter R Schofield, Hiroyuki Shimada, Kazushi Suzuki, Christopher H van Dyck, Gregory Klein, David B Clifford, Carlos Cruchaga, Jason Hassenstab, Yan Li, Eric McDade, Susan Mills, John C Morris, Richard J Perrin, Charlene Supnet-Bell, Guoqiao Wang, Chengjie Xiong, Randall J Bateman, Tammie L S Benzinger, DIAN‐TU Study Team
Regional effects of gantenerumab on neuroimaging biomarkers in the DIAN-TU-001 trial
bioRxiv : the preprint server for biology
Published

Measuring neurofilament light in human plasma and cerebrospinal fluid: a comparison of five analytical immunoassays

Authors
Udit Sheth, Rebecca Harrison, Kyle Ferber, Erin G Rosenbaugh, Amanda Bevis, Rohini Khillan, Michael Benatar, Nicole L Bjorklund, Elena Di Daniel, Glenn A Harris, Olga I Kahn, Yongge Liu, Henrik Zetterberg, Laura L Mitic, Danielle Graham, Tania F Gendron
Measuring neurofilament light in human plasma and cerebrospinal fluid: a comparison of five analytical immunoassays
The lancet. Healthy longevity
Published

Factors related to blood-based biomarkers for neurodegenerative diseases and their intergenerational associations in the Young Finns Study: a cohort study

Authors
Marja A Heiskanen, Juha Mykkänen, Katja Pahkala, Markus Juonala, Mika Kähönen, Terho Lehtimäki, Tomi P Laitinen, Eero Jokinen, Päivi Tossavainen, Anna Linko-Parvinen, Hanna-Mari Pallari, Kaj Blennow, Henrik Zetterberg, Jorma Viikari, Olli Raitakari, Suvi P Rovio
Factors related to blood-based biomarkers for neurodegenerative diseases and their intergenerational associations in the Young Finns Study: a cohort study
Brain communications
Published

Cerebrospinal fluid proteomic profiling of cognitively unimpaired individuals with suspected non-Alzheimer's disease pathophysiology

Authors
Aurore Delvenne, Johan Gobom, Lianne M Reus, Valerija Dobricic, Mara Ten Kate, Suzanne E Schindler, Inez Ramakers, Betty M Tijms, Rik Vandenberghe, Jolien Schaeverbeke, Pablo Martinez-Lage, Mikel Tainta, Charlotte E Teunissen, Julius Popp, Gwendoline Peyratout, Magda Tsolaki, Yvonne Freund-Levi, Simon Lovestone, Johannes Streffer, Frederik Barkhof, Lars Bertram, Kaj Blennow, Henrik Zetterberg, Pieter Jelle Visser, Stephanie J B Vos
Cerebrospinal fluid proteomic profiling of cognitively unimpaired individuals with suspected non-Alzheimer's disease pathophysiology
Journal of neurology
Published

Evaluating finger-prick blood collection for remote quantification of neurofilament light in neurological diseases

Authors
Annabelle Coleman, Alexiane Touzé, Mena Farag, Marta Pengo, Michael J Murphy, Yara Hassan, Olivia Thackeray, Kate Fayer, Sophie Field, Mitsuko Nakajima, Elizabeth L Broom, Nicola Z Hobbs, Brook Huxford, Natalie Donkor, Ellen Camboe, Kamalesh C Dey, Alexandra Zirra, Aisha Ahmed, Ana Rita Gameiro Costa, Harriet Sorrell, Luca Zampedri, Vittoria Lombardi, Charles Wade, Sean Mangion, Batoul Fneich, Amanda Heslegrave, Henrik Zetterberg, Rachael Scahill, Alastair Noyce, Andrea Malaspina, Jeremy Chataway, Sarah J Tabrizi, Lauren M Byrne
Evaluating finger-prick blood collection for remote quantification of neurofilament light in neurological diseases
The journal of prevention of Alzheimer's disease..
Published

Comment by European Alzheimer's Disease Consortium (EADC) investigators on the negative recommendation of the CHMP on the marketing authorization of donanemab for early Alzheimer' s disease

Authors
Frank Jessen, Javier Arbizu, Mercé Boada, Mircea Balasa, Karim Bennys, Marina Boban, Katharina Bürger, Andrea Chincarini, Annachiara Cagnin, Peter Paul De Deyn, Emrah Düzel, Sebastiaan Engelborghs, Michael Ewers, Lieza G Exalto, Wiesje M van der Flier, Juan Fortea, Kristian Steen Frederiksen, Giovanni B Frisoni, Lutz Frölich, Alejandro J Garza-Martinez, Timo Grimmer, Bernard Hanseeuw, Jakub Hort, Adrian Ivanoiu, Patrick G Kehoe, Sean P Kennelly, Silke Kern, Stefan Klöppel, Lenka Krajčovičová, Milica G Kramberger, Bernadette McGuinness, Patrizia Mecocci, Timo Jan Oberstein, Pierre-Jean Ousset, Claire Paquet, Robert Perneczky, Fabrizio Piazza, Domenico Plantone, Innocenzo Rainero, Guillaume Sacco, Eric Salmon, Isabel Santana, Nikolaos Scarmeas, Anja Schneider, Jonathan M Schott, Eino Solje, Elka Stefanova, Elisabeth Stögmann, Mélanie Strauss, Stanislav Sutovsky, Gunhild Waldemar, Bengt Winblad
Comment by European Alzheimer's Disease Consortium (EADC) investigators on the negative recommendation of the CHMP on the marketing authorization of donanemab for early Alzheimer' s disease
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Impact of racialization on neuroimaging and plasma biomarkers of Alzheimer's disease

Authors
Alexandra Gogola, Xuemei Zeng, Lilcelia A Williams, Theresa Chapple-McGruder, Anum Saeed, Brian J Lopresti, Beth Snitz, Dana Tudorascu, Davneet Minhas, Milos D Ikonomovic, Julia Kofler, Cristy Matan, Tharick A Pascoal, Howard Aizenstein, Henrik Zetterberg, Kaj Blennow, Oscar Lopez, Victor L Villemagne, Thomas K Karikari, Ann D Cohen
Impact of racialization on neuroimaging and plasma biomarkers of Alzheimer's disease
Science advances
Published

Enhanced immunocompatibility and hemocompatibility of nanomedicines across multiple species using complement pathway inhibitors

Authors
Yue Li, Sarah Jacques, Hanmant Gaikwad, Morgan Nebbia, Nirmal K Banda, V Michael Holers, Stephen A Tomlinson, Robert I Scheinman, Andrew Monte, Laura Saba, Erika Lasda, Jay Hasselberth, Nicolas Busquet, Wioleta M Zelek, S Moein Moghimi, Dmitri Simberg
Enhanced immunocompatibility and hemocompatibility of nanomedicines across multiple species using complement pathway inhibitors
Stem cell reports
Published

Modeling common Alzheimer's disease with high and low polygenic risk in human iPSC: A large-scale research resource

Authors
Emily Maguire, Jincy Winston, Sarah H Ellwood, Rachel O'Donoghue, Bethany Shaw, Atahualpa Castillo Morales, Samuel Keat, Alexandra Evans, Rachel Marshall, Lauren Luckcuck, Laura Brown, Elisa Salis, Ganna Leonenko, Nicola Denning, EADB consortium, Nicholas D Allen, Valentina Escott-Price, Caleb Webber, Philip R Taylor, Rebecca Sims, Sally A Cowley, Julie Williams, Sarah M Carpanini, Hazel Hall-Roberts
Modeling common Alzheimer's disease with high and low polygenic risk in human iPSC: A large-scale research resource