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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Movement disorders : official journal of the Movement Disorder Society
Published
Systematic Review with Meta-Analysis of Biofluid Markers for Huntington's Disease
Authors
Jane S Paulsen, Natalie A Bovin, Jordan D Clemsen, Alexander Weiss, Abigail M Key, Monica L Janz, Alex Pinto, Deven K Burks, Henrik Zetterberg, Kathleen M Shannon
Systematic Review with Meta-Analysis of Biofluid Markers for Huntington's Disease
Neuron
Published
Integrated omics reveals disease-associated radial glia-like cells with epigenetically dysregulated interferon response in multiple sclerosis
Authors
Bongsoo Park, Alexandra M Nicaise, Dimitrios Tsitsipatis, Liviu Pirvan, Daniel Zucha, Andi Munteanu, Pranathi Prasad, Miguel Larraz Lopez De Novales, Cristian Bulgaru, Rafael Kollyfas, Julia Whitten, Cory M Willis, Luka Culig, Joseph Llewellyn, Rosana-Bristena Ionescu, Magdy Mekdad, Madalena B C Simões-Abade, Grzegorz Krzak, Jinshui Fan, Supriyo De, Matthew O Ellis, Marta Suarez Cubero, Angeliki Spathopoulou, Luca Peruzzotti-Jametti, Tommaso Leonardi, Gabriel Balmus, Frank Edenhofer, Myriam Gorospe, Lukas Valihrach, Irina Mohorianu, Stefano Pluchino, Isabel Beerman
Integrated omics reveals disease-associated radial glia-like cells with epigenetically dysregulated interferon response in multiple sclerosis
EMBO molecular medicine
Published
Glia inflammation and cell death pathways drive disease progression in preclinical and early AD
Authors
Marcel S Woo, Joseph Therriault, Seyyed Ali Hosseini, Yi-Ting Wang, Arthur C Macedo, Nesrine Rahmouni, Étienne Aumont, Stijn Servaes, Cécile Tissot, Jaime Fernandez-Arias, Lydia Trudel, Brandon Hall, Gleb Bezgin, Kely Quispialaya-Socualaya, Marina Goncalves, Tevy Chan, Jenna Stevenson, Yansheng Zheng, Stuart Mitchell, Robert Hopewell, Ilaria Pola, Kubra Tan, Guglielmo Di Molfetta, Firoza Z Lussier, Gassan Massarweh, Paolo Vitali, Jean-Paul Soucy, Serge Gauthier, Nicholas J Ashton, Kaj Blennow, Tharick A Pascoal, Henrik Zetterberg, Andréa L Benedet, Pedro Rosa-Neto
Glia inflammation and cell death pathways drive disease progression in preclinical and early AD
European heart journal
Published
Blood pressure, plasma proteins, and cardiovascular diseases: a network Mendelian randomization and observational study
Authors
Devendra Meena, Jingxian Huang, Alexander Smith, James Yarmolinsky, Siwei Wu, Fotios Koskeridis, Yi-Hsuan Ko, Marie-Joe Dib, Charalabos Antonatos, Yiannis Vasilopoulos, Xinzhu Yu, Georg W Otto, Dipender Gill, Manuel Mayr, Paul Elliott, Abbas Dehghan, Ioanna Tzoulaki
Blood pressure, plasma proteins, and cardiovascular diseases: a network Mendelian randomization and observational study
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Combining plasma p-tau<sub>231</sub> and glial fibrillary acidic protein produces higher discriminative accuracy for amyloid positivity than other blood-based biomarker combinations
Authors
Corey J Bolton, Omair A Khan, Dandan Liu, Kimberly R Pechman, Katherine A Gifford, Timothy J Hohman, Kaj Blennow, Henrik Zetterberg, Angela L Jefferson
Combining plasma p-tau<sub>231</sub> and glial fibrillary acidic protein produces higher discriminative accuracy for amyloid positivity than other blood-based biomarker combinations
Movement disorders : official journal of the Movement Disorder Society
Published
RRP12 Variants Are Associated With Autosomal Recessive Brain Calcifications
Authors
Edoardo Monfrini, Paola Rinchetti, Mathieu Anheim, Anna Klingseisen, Ouhaid Lagha-Boukbiza, Zhidong Cen, Dehao Yang, Xinhui Chen, Reza Maroofian, Henry Houlden, Gioia Cappelletti, Anne-Claire Richard, Olivier Quenez, Camilo Toro, Steven J Frucht, Francesco Lotti, Wei Luo, David Hunt, Gael Nicolas, Giulietta M Riboldi
RRP12 Variants Are Associated With Autosomal Recessive Brain Calcifications
Proceedings of the National Academy of Sciences of the United States of America
Published
The locus coeruleus maintains core body temperature and protects against hypothermia during dexmedetomidine-induced sedation
Authors
Berta Anuncibay Soto, Ying Ma, Mathieu Nollet, Sara Wong, Giulia Miracca, Daniel Rastinejad, Raquel Yustos, Alexei L Vyssotski, Nicholas P Franks, William Wisden
The locus coeruleus maintains core body temperature and protects against hypothermia during dexmedetomidine-induced sedation
Acta pharmaceutica Sinica. B
Published
Artificial intelligence in drug development for delirium and Alzheimer's disease
Authors
Ruixue Ai, Xianglu Xiao, Shenglong Deng, Nan Yang, Xiaodan Xing, Leiv Otto Watne, Geir Selbæk, Yehani Wedatilake, Chenglong Xie, David C Rubinsztein, Jennifer E Palmer, Bjørn Erik Neerland, Hongming Chen, Zhangming Niu, Guang Yang, Evandro Fei Fang
Artificial intelligence in drug development for delirium and Alzheimer's disease
Journal of neurology, neurosurgery, and psychiatry
Published
Midlife plasma proteomic profiles indicate altered amyloid and tau processing in former elite rugby players
Authors
Neil Graham, Karl Zimmerman, Jessica Hain, Erin Rooney, Ying Lee, Martina Del Giovane, Thomas Parker, Mathew Wilson, Maneesh Patel, Elena Veleva, Owen Swann, Amanda J Heslegrave, Lucia M Li, Henrik Zetterberg, Daniel Friedland, Richard Sylvester, David Sharp
Midlife plasma proteomic profiles indicate altered amyloid and tau processing in former elite rugby players
bioRxiv : the preprint server for biology
Published
Rare bioactive tau oligomers from Alzheimer brain support both templated misfolding and fibril formation
Authors
Noé Quittot, Dhanush Sivasankaran, Dorothea Boeken, Yu Chen, Joshua E Chun, Anne Wiedmer, Victoria Derosla, Mariana B M S Martins, Forest A Brooks, Georg Meisl, Matthew Cotton, Durga G Arumuganainar, Theresa Connors, Alexandra Melloni, Mathew Frosch, Derek Oakley, Lee Makowski, Meni Wanunu, David Klenerman, Bradley T Hyman
Rare bioactive tau oligomers from Alzheimer brain support both templated misfolding and fibril formation
Nature biomedical engineering
Published
Large-scale visualization of α-synuclein oligomers in Parkinson's disease brain tissue
Authors
Rebecca Andrews, Bin Fu, Christina E Toomey, Jonathan C Breiter, Joanne Lachica, Joseph S Beckwith, Ru Tian, Emma E Brock, Lisa-Maria Needham, Gregory J Chant, Camille Loiseau, Angèle Deconfin, Kenza Baspin, Rebeka Popovic, James Evans, Yen Goh, Begüm Kurt, Lenart Senicar, Marisa Edmonds, Tim Bartels, Nora Bengoa-Vergniory, Peter J Magill, Zane Jaunmuktane, Oliver J Freeman, Benjamin J M Taylor, John Hardy, Tammaryn Lashley, Mina Ryten, Michele Vendruscolo, Nicholas W Wood, Lucien E Weiss, Sonia Gandhi, Steven F Lee
Large-scale visualization of α-synuclein oligomers in Parkinson's disease brain tissue
bioRxiv : the preprint server for biology
Published
Generation of <em>C9orf72</em> repeat knock-in iPSC lines for modelling ALS and FTD
Authors
Rachel Coneys, Alexander J Cammack, Remya R Nair, David Thompson, Jonas Mechtersheimer, Mireia Carcolé, Yashica Gupta, Gabriel E Rech, Michael Flower, Niamh O'Brien, Marc-David Ruepp, Sarah Mizielinska, Fiona Ducotterd, Sarah J Tabrizi, Elizabeth M C Fisher, Thomas J Cunningham, Michael Ward, William C Skarnes, Adrian M Isaacs
Generation of <em>C9orf72</em> repeat knock-in iPSC lines for modelling ALS and FTD