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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

medRxiv : the preprint server for health sciences
Published
The impact of cardiorespiratory fitness on Alzheimer's disease biomarkers and their relationships with cognitive decline
Authors
A J Paulsen, I Driscoll, B M Breidenbach, M P Glittenberg, S R Lose, Y Ma, M A Sager, C M Carlsson, C L Gallagher, B P Hermann, K Blennow, H Zetterberg, S Asthana, S C Johnson, T J Betthauser, B T Christian, D B Cook, O C Okonkwo
The impact of cardiorespiratory fitness on Alzheimer's disease biomarkers and their relationships with cognitive decline
medRxiv : the preprint server for health sciences
Published
Older more fit KL-VS heterozygotes have more favorable AD-relevant biomarker profiles
Authors
Mackenzie Jarchow, Ira Driscoll, Brianne M Breidenbach, Noah Cook, Catherine L Gallagher, Sterling C Johnson, Sanjay Asthana, Bruce P Hermann, Mark A Sager, Kaj Blennow, Henrik Zetterberg, Cynthia M Carlsson, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Dane B Cook, Dena B Dubal, Ozioma C Okonkwo
Older more fit KL-VS heterozygotes have more favorable AD-relevant biomarker profiles
Nature communications
Published
Axonal RNA localization is essential for long-term memory
Authors
Bruna R de Queiroz, Hiba Laghrissi, Seetha Rajeev, Lauren Blot, Fabienne De Graeve, Marine Dehecq, Martina Hallegger, Ugur Dag, Marion Dunoyer de Segonzac, Mirana Ramialison, Chantal Cazevieille, Krystyna Keleman, Jernej Ule, Arnaud Hubstenberger, Florence Besse
Axonal RNA localization is essential for long-term memory
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
Published
How does autophagy impact neurological function?
Authors
Angeleen Fleming, Ana Lopez, Matea Rob, Sarayu Ramakrishna, So Jung Park, Xinyi Li, David C Rubinsztein
How does autophagy impact neurological function?
bioRxiv : the preprint server for biology
Published
Apolipoprotein E abundance is elevated in the brains of individuals with Down syndrome-Alzheimer's disease
Authors
Clíona Farrell, Yazead Buhidma, Paige Mumford, Wendy E Heywood, Jenny Hällqvist, Lisi Flores-Aguilar, Elizabeth Andrews, Negin Rahimzadah, Orjona Stella Taso, Eric Doran, Vivek Swarup, Elizabeth Head, Tammaryn Lashley, Kevin Mills, Christina E Toomey, Frances K Wiseman
Apolipoprotein E abundance is elevated in the brains of individuals with Down syndrome-Alzheimer's disease
Nature neuroscience
Published
Author Correction: Neuronal polyunsaturated fatty acids are protective in ALS/FTD
Authors
Ashling Giblin, Alexander J Cammack, Niek Blomberg, Sharifah Anoar, Alla Mikheenko, Mireia Carcolé, Magda L Atilano, Alex Hull, Dunxin Shen, Xiaoya Wei, Rachel Coneys, Lele Zhou, Yassene Mohammed, Damien Olivier-Jimenez, Lian Y Wang, Kerri J Kinghorn, Teresa Niccoli, Alyssa N Coyne, Rik van der Kant, Tammaryn Lashley, Martin Giera, Linda Partridge, Adrian M Isaacs
Author Correction: Neuronal polyunsaturated fatty acids are protective in ALS/FTD
Cell systems
Published
Integrated multi-omic characterizations of the synapse reveal RNA processing factors and ubiquitin ligases associated with neurodevelopmental disorders
Authors
Yuan Mei, Maya L Gosztyla, Xinzhu Tan, Lara E Dozier, Brent Wilkinson, Justin McKetney, John Lee, Michael Chen, Dorothy Tsai, Hema Kopalle, Marina A Gritsenko, Nicolas Hartel, Nicholas A Graham, Ilse Flores, Stephen K Gilmore-Hall, Shuhao Xu, Charlotte A Marquez, Sophie N Liu, Dylan Fong, Jing Chen, Kate Licon, Derek Hong, Sarah N Wright, Jason F Kreisberg, Alexi Nott, Richard D Smith, Wei-Jun Qian, Danielle L Swaney, Lilia M Iakoucheva, Nevan J Krogan, Gentry N Patrick, Yang Zhou, Guoping Feng, Marcelo P Coba, Gene W Yeo, Trey Ideker
Integrated multi-omic characterizations of the synapse reveal RNA processing factors and ubiquitin ligases associated with neurodevelopmental disorders
The Journal of pharmacology and experimental therapeutics
Published
γ-Secretase modulation inhibits amyloid plaque formation and growth and stimulates plaque regression in amyloid precursor protein/presenilin-1 mice
Authors
Gunnar Nordvall, Ping Yan, Lotta Agholme, Johan Lundkvist, Johan Sandin, Henrik Biverstål, Bengt Winblad, Henrik Zetterberg, Rebecka Klintenberg, Mats Ferm, John R Cirrito, Jin-Moo Lee
γ-Secretase modulation inhibits amyloid plaque formation and growth and stimulates plaque regression in amyloid precursor protein/presenilin-1 mice
Annals of clinical and translational neurology
Published
Calcium modulating ligand confers risk for Parkinson's disease and impacts lysosomes
Authors
Hanwen Zhang, Daniel Kargilis, Thomas Tropea, John Robinson, Junchao Shen, Eliza M Brody, Ann Brinkmalm, Simon Sjödin, Adama J Berndt, Marc Carceles-Cordon, EunRan Suh, Vivianna M Van Deerlin, Kaj Blennow, Daniel Weintraub, Edward B Lee, Henrik Zetterberg, Alice S Chen-Plotkin
Calcium modulating ligand confers risk for Parkinson's disease and impacts lysosomes
Journal of neurology
Published
Tau levels in platelets isolated from Huntington's disease patients serve as a biomarker of disease severity
Authors
Melanie Alpaugh, Juan Lantero-Rodriguez, Andrea L Benedet, Uriel Manseau, Martine Boutin, Massimo Maiuri, Helena L Denis, Maria Masnata, Shaline V Fazal, Sylvain Chouinard, Pedro Rosa-Neto, Roger A Barker, Kaj Blennow, Henrik Zetterberg, Richard Labib, Francesca Cicchetti
Tau levels in platelets isolated from Huntington's disease patients serve as a biomarker of disease severity
JAMA network open
Published
Physical Activity, Alzheimer Plasma Biomarkers, and Cognition
Authors
Seung Ae Kim, Daeun Shin, Hongki Ham, Yeshin Kim, Yuna Gu, Hee Jin Kim, Duk L Na, Henrik Zetterberg, Kaj Blennow, Sang Won Seo, Hyemin Jang, Precision Medicine Platform for Mild Cognitive Impairment Based on Multi-omics, Imaging, Evidence-Based R&BD (PREMIER) Consortium
Physical Activity, Alzheimer Plasma Biomarkers, and Cognition