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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

EMBO J
Published

Microglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models.

Authors
Javier Rueda-Carrasco, Dimitra Sokolova, Sang-Eun Lee, Thomas Childs, Natália Jurčáková, Gerard Crowley, Sebastiaan De Schepper, Judy Z Ge, Joanne I Lachica, Christina E Toomey, Oliver J Freeman, John Hardy, Samuel J Barnes, Tammaryn Lashley, Beth Stevens, Sunghoe Chang, Soyon Hong
Microglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models.
Sci Data
Published

TIHM: An open dataset for remote healthcare monitoring in dementia.

Authors
Francesca Palermo, Yu Chen, Alexander Capstick, Nan Fletcher-Loyd, Chloe Walsh, Samaneh Kouchaki, Jessica True, Olga Balazikova, Eyal Soreq, Gregory Scott, Helen Rostill, Ramin Nilforooshan, Payam Barnaghi
TIHM: An open dataset for remote healthcare monitoring in dementia.
Nat Commun
Published

Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases.

Authors
Erik Nutma, Nurun Fancy, Maria Weinert, Stergios Tsartsalis, Manuel C Marzin, Robert C J Muirhead, Irene Falk, Marjolein Breur, Joy de Bruin, David Hollaus, Robin Pieterman, Jasper Anink, David Story, Siddharthan Chandran, Jiabin Tang, Maria C Trolese, Takashi Saito, Takaomi C Saido, Katharine H Wiltshire, Paula Beltran-Lobo, Alexandra Phillips, Jack Antel, Luke Healy, Marie-France Dorion, Dylan A Galloway, Rochelle Y Benoit, Quentin Amossé, Kelly Ceyzériat, Aurélien M Badina, Enikö Kövari, Caterina Bendotti, Eleonora Aronica, Carola I Radulescu, Jia Hui Wong, Anna M Barron, Amy M Smith, Samuel J Barnes, David W Hampton, Paul van der Valk, Steven Jacobson, Owain W Howell, David Baker, Markus Kipp, Hannes Kaddatz, Benjamin B Tournier, Philippe Millet, Paul M Matthews, Craig S Moore, Sandra Amor, David R Owen
Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases.
Acta Neuropathol Commun
Published

Cathepsin B abundance, activity and microglial localisation in Alzheimer's disease-Down syndrome and early onset Alzheimer's disease; the role of elevated cystatin B.

Authors
Yixing Wu, Paige Mumford, Suzanna Noy, Karen Cleverley, Alicja Mrzyglod, Dinghao Luo, Floris van Dalen, Martijn Verdoes, Elizabeth M C Fisher, Frances K Wiseman
Cathepsin B abundance, activity and microglial localisation in Alzheimer's disease-Down syndrome and early onset Alzheimer's disease; the role of elevated cystatin B.
JAMA
Published

Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial.

Authors
John R Sims, Jennifer A Zimmer, Cynthia D Evans, Ming Lu, Paul Ardayfio, JonDavid Sparks, Alette M Wessels, Sergey Shcherbinin, Hong Wang, Emel Serap Monkul Nery, Emily C Collins, Paul Solomon, Stephen Salloway, Liana G Apostolova, Oskar Hansson, Craig Ritchie, Dawn A Brooks, Mark Mintun, Daniel M Skovronsky,
Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial.
BMJ Open
Published

Multicohort cross-sectional study of cognitive and behavioural digital biomarkers in neurodegeneration: the Living Lab Study protocol.

Authors
Mark Crook-Rumsey, Sarah J C Daniels, Subati Abulikemu, Helen Lai, Adrien Rapeaux, Charalambos Hadjipanayi, Eyal Soreq, Lucia M Li, James Bashford, Julian Jeyasingh-Jacob, Dragos C Gruia, Damion Lambert, Rimona Weil, Adam Hampshire, David J Sharp, Shlomi Haar
Multicohort cross-sectional study of cognitive and behavioural digital biomarkers in neurodegeneration: the Living Lab Study protocol.
Brain
Published

Microglial activation in the frontal cortex predicts cognitive decline in frontotemporal dementia.

Authors
Maura Malpetti, Thomas E Cope, Duncan Street, P Simon Jones, Frank H Hezemans, Elijah Mak, Kamen A Tsvetanov, Timothy Rittman, W Richard Bevan-Jones, Karalyn Patterson, Luca Passamonti, Tim D Fryer, Young T Hong, Franklin I Aigbirhio, John T O'Brien, James B Rowe
Microglial activation in the frontal cortex predicts cognitive decline in frontotemporal dementia.
Cell Rep
Published

Super-resolution imaging unveils the self-replication of tau aggregates upon seeding.

Authors
Eleni Dimou, Taxiarchis Katsinelos, Georg Meisl, Benjamin J Tuck, Sophie Keeling, Annabel E Smith, Eric Hidari, Jeff Y L Lam, Melanie Burke, Sofia Lövestam, Rohan T Ranasinghe, William A McEwan, David Klenerman
Super-resolution imaging unveils the self-replication of tau aggregates upon seeding.