Publications

Featured

Oct 31, 2024 - Research

Glaucoma drug shows promise against neurodegenerative diseases, animal studies suggest

A drug commonly used to treat glaucoma has been shown in zebrafish and mice to protect against the build-up in the brain of the protein...

Learn more Glaucoma drug shows promise against neurodegenerative diseases, animal studies suggest

Two people sit in wheelchairs next to one another

Sep 19, 2024 - Research

First results published from innovative platform trial, MND-SMART, aiming to speed up delivery of treatments for motor neuron disease

The first results from the innovative platform trial, MND-SMART, have been published in the journal The Lancet Neurology today. Led by Prof Siddharthan Chandran (UK...

Learn more First results published from innovative platform trial, MND-SMART, aiming to speed up delivery of treatments for motor neuron disease

Illustration of the inside of a blood vessel

Sep 18, 2024 - Research

Effects of reduced blood flow in early Alzheimer’s reversed by repurposed drug

A new mouse study led by Prof David Attwell (BHF-UK DRI Centre for Vascular Dementia Research) has found that a repurposed drug could reverse the...

Learn more Effects of reduced blood flow in early Alzheimer’s reversed by repurposed drug

Hum Mol Genet

Published Feb 01, 2017

Transcriptomic profiling of purified patient-derived dopamine neurons identifies convergent perturbations and therapeutics for Parkinson's disease.

Authors

Cynthia Sandor, Paul Robertson, Charmaine Lang, Andreas Heger, Heather Booth, Jane Vowles, Lorna Witty, Rory Bowden, Michele Hu, Sally A Cowley, Richard Wade-Martins, Caleb Webber

Transcriptomic profiling of purified patient-derived dopamine neurons identifies convergent perturbations and therapeutics for Parkinson's disease.

Nature

Published Jan 25, 2017

PLD3 gene and processing of APP.

Authors

Pietro Fazzari, Katrien Horre, Amaia M Arranz, Carlo Sala Frigerio, Takashi Saito, Takaomi C Saido, Bart De Strooper

PLD3 gene and processing of APP.

Neuron

Published Jan 18, 2017

Phase-Locked Inhibition, but Not Excitation, Underlies Hippocampal Ripple Oscillations in Awake Mice In Vivo.

Authors

Jian Gan, Shih-Ming Weng, Alejandro J Pernía-Andrade, Jozsef Csicsvari, Peter Jonas

Phase-Locked Inhibition, but Not Excitation, Underlies Hippocampal Ripple Oscillations in Awake Mice In Vivo.

Blood

Published Dec 15, 2016

Type I interferon causes thrombotic microangiopathy by a dose-dependent toxic effect on the microvasculature.

Authors

David Kavanagh, Sarah McGlasson, Alexa Jury, Jac Williams, Neil Scolding, Chris Bellamy, Claudia Gunther, Diane Ritchie, Daniel P Gale, Yashpal S Kanwar, Rachel Challis, Holly Buist, James Overell, Belinda Weller, Oliver Flossmann, Mark Blunden, Eric P Meyer, Thomas Krucker, Stephen J W Evans, Iain L Campbell, Andrew P Jackson, Siddharthan Chandran, David P J Hunt

Type I interferon causes thrombotic microangiopathy by a dose-dependent toxic effect on the microvasculature.

Nat Commun

Published Nov 09, 2016

Contracting CAG/CTG repeats using the CRISPR-Cas9 nickase.

Authors

Cinzia Cinesi, Lorène Aeschbach, Bin Yang, Vincent Dion

Contracting CAG/CTG repeats using the CRISPR-Cas9 nickase.

Neurology

Published Nov 08, 2016

Presymptomatic cortical thinning in familial Alzheimer disease: A longitudinal MRI study.

Authors

Philip S J Weston, Jennifer M Nicholas, Manja Lehmann, Natalie S Ryan, Yuying Liang, Kirsty Macpherson, Marc Modat, Martin N Rossor, Jonathan M Schott, Sebastien Ourselin, Nick C Fox

Presymptomatic cortical thinning in familial Alzheimer disease: A longitudinal MRI study.

Genes Dev

Published Oct 01, 2016

Synthetic lethality between PAXX and XLF in mammalian development.

Authors

Gabriel Balmus, Ana C Barros, Paul W G Wijnhoven, Chloé Lescale, Hélène Lenden Hasse, Katharina Boroviak, Carlos le Sage, Brendan Doe, Anneliese O Speak, Antonella Galli, Matt Jacobsen, Ludovic Deriano, David J Adams, Andrew N Blackford, Stephen P Jackson

Synthetic lethality between PAXX and XLF in mammalian development.

Mol Neurodegener

Published Sep 29, 2016

Cerebrospinal fluid Presenilin-1 increases at asymptomatic stage in genetically determined Alzheimer's disease.

Authors

Aitana Sogorb-Esteve, María-Salud García-Ayllón, Juan Fortea, Raquel Sánchez-Valle, Alberto Lleó, José-Luis Molinuevo, Javier Sáez-Valero

Cerebrospinal fluid Presenilin-1 increases at asymptomatic stage in genetically determined Alzheimer's disease.

Lancet

Published Jul 30, 2016

Alzheimer's disease.

Authors

Philip Scheltens, Kaj Blennow, Monique M B Breteler, Bart de Strooper, Giovanni B Frisoni, Stephen Salloway, Wiesje Maria Van der Flier

Alzheimer's disease.

EMBO J

Published Jul 15, 2016

Minor intron splicing is regulated by FUS and affected by ALS-associated FUS mutants.

Authors

Stefan Reber, Jolanda Stettler, Giuseppe Filosa, Martino Colombo, Daniel Jutzi, Silvia C Lenzken, Christoph Schweingruber, Rémy Bruggmann, Angela Bachi, Silvia Ml Barabino, Oliver Mühlemann, Marc-David Ruepp

Minor intron splicing is regulated by FUS and affected by ALS-associated FUS mutants.

Mol Neurodegener

Published Jun 10, 2016

Synaptophysin depletion and intraneuronal Aβ in organotypic hippocampal slice cultures from huAPP transgenic mice.

Authors

Claire S Harwell, Michael P Coleman

Synaptophysin depletion and intraneuronal Aβ in organotypic hippocampal slice cultures from huAPP transgenic mice.

Science

Published May 06, 2016

Complement and microglia mediate early synapse loss in Alzheimer mouse models.

Authors

Soyon Hong, Victoria F Beja-Glasser, Bianca M Nfonoyim, Arnaud Frouin, Shaomin Li, Saranya Ramakrishnan, Katherine M Merry, Qiaoqiao Shi, Arnon Rosenthal, Ben A Barres, Cynthia A Lemere, Dennis J Selkoe, Beth Stevens

Complement and microglia mediate early synapse loss in Alzheimer mouse models.

Neuron

Published Apr 20, 2016

Familial Alzheimer's Disease Mutations in Presenilin Generate Amyloidogenic Aβ Peptide Seeds.

Authors

Sarah Veugelen, Takashi Saito, Takaomi C Saido, Lucía Chávez-Gutiérrez, Bart De Strooper

Familial Alzheimer's Disease Mutations in Presenilin Generate Amyloidogenic Aβ Peptide Seeds.

Proc Natl Acad Sci U S A

Published Apr 12, 2016

S-nitrosation of proteins relevant to Alzheimer's disease during early stages of neurodegeneration.

Authors

Uthpala Seneviratne, Alexi Nott, Vadiraja B Bhat, Kodihalli C Ravindra, John S Wishnok, Li-Huei Tsai, Steven R Tannenbaum

S-nitrosation of proteins relevant to Alzheimer's disease during early stages of neurodegeneration.

Cell

Published Feb 11, 2016

The Cellular Phase of Alzheimer's Disease.

Authors

Bart De Strooper, Eric Karran

The Cellular Phase of Alzheimer's Disease.

J Cell Biol

Published Oct 26, 2015

ERO1-independent production of H2O2 within the endoplasmic reticulum fuels Prdx4-mediated oxidative protein folding.

Authors

Tasuku Konno, Eduardo Pinho Melo, Carlos Lopes, Ilir Mehmeti, Sigurd Lenzen, David Ron, Edward Avezov

ERO1-independent production of H2O2 within the endoplasmic reticulum fuels Prdx4-mediated oxidative protein folding.

Cell

Published Jul 30, 2015

The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis.

Authors

Michael J Parsons, Marco Brancaccio, Siddharth Sethi, Elizabeth S Maywood, Rahul Satija, Jessica K Edwards, Aarti Jagannath, Yvonne Couch, Mattéa J Finelli, Nicola J Smyllie, Christopher Esapa, Rachel Butler, Alun R Barnard, Johanna E Chesham, Shoko Saito, Greg Joynson, Sara Wells, Russell G Foster, Peter L Oliver, Michelle M Simon, Ann-Marie Mallon, Michael H Hastings, Patrick M Nolan

The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis.

Neuron

Published Apr 22, 2015

Lengthening of the Stargazin Cytoplasmic Tail Increases Synaptic Transmission by Promoting Interaction to Deeper Domains of PSD-95.

Authors

Anne-Sophie Hafner, Andrew C Penn, Dolors Grillo-Bosch, Natacha Retailleau, Christel Poujol, Amandine Philippat, Françoise Coussen, Matthieu Sainlos, Patricio Opazo, Daniel Choquet

Lengthening of the Stargazin Cytoplasmic Tail Increases Synaptic Transmission by Promoting Interaction to Deeper Domains of PSD-95.

Shaping the future of dementia research: Meet the UK DRI’s newest Emerging Leaders

Why partner with the UK DRI?

Why join the UK DRI?

Publications

Featured

Glaucoma drug shows promise against neurodegenerative diseases, animal studies suggest

First results published from innovative platform trial, MND-SMART, aiming to speed up delivery of treatments for motor neuron disease

Effects of reduced blood flow in early Alzheimer’s reversed by repurposed drug

Transcriptomic profiling of purified patient-derived dopamine neurons identifies convergent perturbations and therapeutics for Parkinson's disease.

PLD3 gene and processing of APP.

Phase-Locked Inhibition, but Not Excitation, Underlies Hippocampal Ripple Oscillations in Awake Mice In Vivo.

Type I interferon causes thrombotic microangiopathy by a dose-dependent toxic effect on the microvasculature.

Contracting CAG/CTG repeats using the CRISPR-Cas9 nickase.

Presymptomatic cortical thinning in familial Alzheimer disease: A longitudinal MRI study.

Synthetic lethality between PAXX and XLF in mammalian development.

Cerebrospinal fluid Presenilin-1 increases at asymptomatic stage in genetically determined Alzheimer's disease.

Alzheimer's disease.

Minor intron splicing is regulated by FUS and affected by ALS-associated FUS mutants.

Synaptophysin depletion and intraneuronal Aβ in organotypic hippocampal slice cultures from huAPP transgenic mice.

Complement and microglia mediate early synapse loss in Alzheimer mouse models.

Familial Alzheimer's Disease Mutations in Presenilin Generate Amyloidogenic Aβ Peptide Seeds.

S-nitrosation of proteins relevant to Alzheimer's disease during early stages of neurodegeneration.

The Cellular Phase of Alzheimer's Disease.

ERO1-independent production of H2O2 within the endoplasmic reticulum fuels Prdx4-mediated oxidative protein folding.

The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis.

Lengthening of the Stargazin Cytoplasmic Tail Increases Synaptic Transmission by Promoting Interaction to Deeper Domains of PSD-95.