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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Nature neuroscience
Published
Activity-driven myelin sheath growth is mediated by mGluR5
Authors
Philipp N Braaker, Xuelong Mi, Daniel Soong, Jenea M Bin, Katy Marshall-Phelps, Stephen Bradley, Silvia Benito-Kwiecinski, Julia Meng, Donia Arafa, Claire Richmond, Marcus Keatinge, Guoqiang Yu, Rafael G Almeida, David A Lyons
Activity-driven myelin sheath growth is mediated by mGluR5
Brain Commun
Published
Vasomotion loss precedes impaired cerebrovascular reactivity and microbleeds in cerebral amyloid angiopathy.
Authors
Mariel G Kozberg, Leon P Munting, Lee H Hanlin, Corinne A Auger, Maarten L van den Berg, Baudouin Denis de Senneville, Lydiane Hirschler, Jan M Warnking, Emmanuel L Barbier, Christian T Farrar, Steven M Greenberg, Brian J Bacskai, Susanne J van Veluw
Vasomotion loss precedes impaired cerebrovascular reactivity and microbleeds in cerebral amyloid angiopathy.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Misfolded α-synuclein co-occurrence with Alzheimer's disease proteinopathy
Authors
Erin M Jonaitis, Karen MacLeod, Jennifer Lamoureux, Beckie Jeffers, Rachel L Studer, John Middleton, Rachael E Wilson, Nathaniel A Chin, Ozioma C Okonkwo, Barbara B Bendlin, Sanjay Asthana, Cynthia M Carlsson, Catherine L Gallagher, Bruce Hermann, Sean McEvoy, Gwendlyn Kollmorgen, Henrik Zetterberg, Luis Concha-Marambio, Sterling C Johnson, Russ M Lebovitz, Rebecca E Langhough
Misfolded α-synuclein co-occurrence with Alzheimer's disease proteinopathy
Lancet (London, England)
Published
Efficacy and safety of low-dose IL-2 as an add-on therapy to riluzole (MIROCALS): a phase 2b, double-blind, randomised, placebo-controlled trial
Authors
Gilbert Bensimon, P Nigel Leigh, Timothy Tree, Andrea Malaspina, Christine Am Payan, Hang-Phuong Pham, Pieter Klaassen, Pamela J Shaw, Ahmad Al Khleifat, Maria D M Amador, Shahram Attarian, Simon M Bell, Stéphane Beltran, Emilien Bernard, William Camu, Philippe Corcia, Jean-Christophe Corvol, Philippe Couratier, Véronique Danel, Rabab Debs, Claude Desnuelle, Aikaterini Dimitriou, John Ealing, Florence Esselin, Marie-Céline Fleury, George H Gorrie, Aude-Marie Grapperon, Adèle Hesters, Raul Juntas-Morales, Ivan Kolev, Géraldine Lautrette, Nadine Le Forestier, Christopher J McDermott, Nicolas Pageot, François Salachas, Nikhil Sharma, Marie-Hélène Soriani, Jemeen Sreedharan, Juliette Svahn, Nick Verber, Annie Verschueren, Ozlem Yildiz, Carey M Suehs, Safaa Saker-Delye, Claudie Muller, Christophe Masseguin, Hana Hajduchova, Janine Kirby, Cecilia Garlanda, Massimo Locati, Henrik Zetterberg, Bernard Asselain, Ammar Al-Chalabi, MIROCALS Study Group
Efficacy and safety of low-dose IL-2 as an add-on therapy to riluzole (MIROCALS): a phase 2b, double-blind, randomised, placebo-controlled trial
Alzheimer's & dementia (Amsterdam, Netherlands)
Published
Cerebrospinal fluid YKL-40 relates to white matter hyperintensity progression in females but not males over a 6-year period
Authors
Amalia J Peterson, Yunyi Sun, Derek B Archer, Hailey A Adegboye, Elizabeth E Moore, Isabella Deberghes, Kimberly R Pechman, Niranjana Shashikumar, W Hudson Robb, Abigail W Workmeister, T Bryan Jackson, Dandan Liu, Logan Dumitrescu, L Taylor Davis, Bennett A Landman, Kaj Blennow, Henrik Zetterberg, Timothy J Hohman, Angela L Jefferson
Cerebrospinal fluid YKL-40 relates to white matter hyperintensity progression in females but not males over a 6-year period
Cell reports
Published
A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neurons
Authors
Benedikt V Hölbling, Yashica Gupta, Paolo M Marchi, Magda L Atilano, Michael Flower, Enric Ureña, Rajkumar A Goulden, Hannah K Dobbs, Eszter Katona, Alla Mikheenko, Ashling Giblin, Ali Raza Awan, Chloe L Fisher-Ward, Niamh O'Brien, Deniz Vaizoglu, Liam Kempthorne, Katherine M Wilson, Lauren M Gittings, Mireia Carcolé, Marc-David Ruepp, Sarah Mizielinska, Linda Partridge, Pietro Fratta, Sarah J Tabrizi, Bhuvaneish T Selvaraj, Siddharthan Chandran, Emma Armstrong, Paul Whiting, Adrian M Isaacs
A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neurons
EBioMedicine
Published
Blood-brain barrier injury and neuroinflammation in pre-eclampsia and eclampsia
Authors
Valentina Bucher, Owen T Herrock, Sonja Schell, Jacqui Visser, Henrik Imberg, Jonathan Burke, Henrik Zetterberg, Kaj Blennow, Susan P Walker, Stephen Tong, Joakim Ek, Catherine Cluver, Lina Bergman
Blood-brain barrier injury and neuroinflammation in pre-eclampsia and eclampsia
BMC nephrology
Published
Plasma concentrations of neurofilament light, p-Tau231 and glial fibrillary acidic protein are elevated in patients with chronic kidney disease and correlate with measured glomerular filtration rate
Authors
Torunn Axelsson, Henrik Zetterberg, Kaj Blennow, Burak Arslan, Nicholas J Ashton, Markus Axelsson, Maria K Svensson, Aso Saeed, Gregor Guron
Plasma concentrations of neurofilament light, p-Tau231 and glial fibrillary acidic protein are elevated in patients with chronic kidney disease and correlate with measured glomerular filtration rate
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Plasma GFAP for populational enrichment of clinical trials in preclinical Alzheimer's disease
Authors
Bruna Bellaver, Guilherme Povala, Pamela C L Ferreira, Guilherme Bauer-Negrini, Firoza Z Lussier, Douglas T Leffa, João Pedro Ferrari-Souza, Matheus S Rodrigues, Livia Amaral, Markley S Oliveira, Carolina Soares, Andreia Rocha, Pampa Saha, Nesrine Rahmouni, Arthur Macedo, Cécile Tissot, Joseph Therriault, Stijn Servaes, Jesse Klostranec, Maxime Montembeault, Andréa L Benedet, Nicholas J Ashton, Rebecca Langhough Koscik, Tobey J Betthauser, Brad T Christian, Rachael Wilson, Gallen Triana-Baltzer, Paolo Vitali, Serge Gauthier, Henrik Zetterberg, Kaj Blennow, Thomas K Karikari, Dana Tudorascu, Eduardo R Zimmer, Sterling Johnson, Pedro Rosa-Neto, Tharick A Pascoal
Plasma GFAP for populational enrichment of clinical trials in preclinical Alzheimer's disease
JAMA network open
Published
Cerebral Amyloid Angiopathy and Downstream Alzheimer Disease Plasma Biomarkers
Authors
Sung Hoon Kang, Eun Hye Lee, Young Ju Kim, Hyemin Jang, Daeun Shin, Henrik Zetterberg, Kaj Blennow, Fernando Gonzalez-Ortiz, Nicholas J Ashton, Jihwan Yun, Hee Jin Kim, Duk L Na, Jun Pyo Kim, Sang Won Seo
Cerebral Amyloid Angiopathy and Downstream Alzheimer Disease Plasma Biomarkers
Molecular neurodegeneration
Published
Cerebrospinal fluid proteome profiling across the Alzheimer's disease continuum: a step towards solving the equation for 'X'
Authors
Sophia Weiner, Mathias Sauer, Laia Montoliu-Gaya, Andrea L Benedet, Nicholas J Ashton, Fernando Gonzalez-Ortiz, Joel Simrén, Nesrine Rahmouni, Cecile Tissot, Joseph Therriault, Stijn Servaes, Jenna Stevenson, Ville Leinonen, Tuomas Rauramaa, Mikko Hiltunen, Pedro Rosa-Neto, Kaj Blennow, Henrik Zetterberg, Johan Gobom
Cerebrospinal fluid proteome profiling across the Alzheimer's disease continuum: a step towards solving the equation for 'X'
medRxiv : the preprint server for health sciences
Published
Genome-wide association study and multi-ancestry meta-analysis identify common variants associated with carotid artery intima-media thickness
Authors
Devendra Meena, Jian Huang, Marjan Zare, Natalie R Hasbani, Boua Palwendé Romuald, Rima Mustafa, Sander W van der Laan, Huichun Xu, James G Terry, Joshua C Bis, Deepti Jain, Nicholette D Palmer, Nancy Heard-Costa, Yuan-I Min, Xiuqing Guo, Jie Yao, Kent D Taylor, Jingyi Tan, Juan Peralta, Alexandre C Pereira, Alyna Khan, Ananyo Choudhury, Anne B Newman, Anny H Xiang, Aroon Hingorani, Barry I Freedman, Christopher J O'Donnell, Claudia Giambartolomei, David M Herrington, David R Jacobs, Derek Klarin, Fei Fei Wang, Gerardo Heiss, HarshaVardhan Doddapaneni, Howard N Hodis, Jai Broome, James G Wilson, Jean-Tristan Brandenburg, John Blangero, Jose E Krieger, Josh D Smith, Karine A Viaud-Martinez, Kathleen A Ryan, Leslie A Lange, May E Montasser, Michael C Mahaney, Michal Mokry, Myriam Fornage, Patricia Munroe, Richard A Gibbs, Russell P Tracy, Ryan W Kim, Scott M Damrauer, Stephen S Rich, Willa A Hsueh, Yii-Der Ida Chen, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, The Million Veteran Program (MVP), TOPMed Atherosclerosis Working Group, Alanna C Morrison, Braxton D Mitchell, John Jeffrey Carr, Bruce M Psaty, Donald W Bowden, Ramachandran S Vasan, Adolfo Correa, Wendy S Post, Mark O Goodarzi, Leslie J Raffel, Joanne E Curran, Michele Ramsay, Jerome I Rotter, Paul Elliott, Nora Franceschini, Paul S de Vries, Ioanna Tzoulaki, Abbas Dehghan
Genome-wide association study and multi-ancestry meta-analysis identify common variants associated with carotid artery intima-media thickness