Publications

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Jan 17, 2025 - Research

Brain changes in Huntington’s disease occur decades before diagnosis

Subtle changes in the brain happen approximately twenty years before a clinical motor diagnosis in people with Huntington’s disease, finds a new study led by...

Learn more Brain changes in Huntington’s disease occur decades before diagnosis

Jan 08, 2025 - Research

Genetic changes in brain cells link ageing and Alzheimer’s

Genetic differences that contribute to how long a person will live and their risk of Alzheimer’s disease have been identified in a new study led...

Learn more Genetic changes in brain cells link ageing and Alzheimer’s

Phospho-tau accumulation in MAPT knockout mice

Jan 08, 2025 - Research

Brain damage starts before tau protein clumps in frontotemporal dementia and Alzheimer’s

A new study led by Prof Karen Duff, Dr Naoto Watamura, and Dr Martha Foiani (UK DRI at UCL), with Prof Takaomi Saido (Riken Center...

Learn more Brain damage starts before tau protein clumps in frontotemporal dementia and Alzheimer’s

Brain Behav Immun

Published Aug 14, 2021

Dissociable effects of complement C3 and C3aR on survival and morphology of adult born hippocampal neurons, pattern separation, and cognitive flexibility in male mice.

Authors

Laura J Westacott, Niels Haan, Claudia Evison, Omar Marei, Jeremy Hall, Timothy R Hughes, Malik Zaben, B Paul Morgan, Trevor Humby, Lawrence S Wilkinson, William P Gray

Dissociable effects of complement C3 and C3aR on survival and morphology of adult born hippocampal neurons, pattern separation, and cognitive flexibility in male mice.

Cell Rep

Published Aug 10, 2021

Molecular and functional properties of cortical astrocytes during peripherally induced neuroinflammation.

Authors

Blanca Diaz-Castro, Alexander M Bernstein, Giovanni Coppola, Michael V Sofroniew, Baljit S Khakh

Molecular and functional properties of cortical astrocytes during peripherally induced neuroinflammation.

Brain Commun

Published Aug 06, 2021

TDP-43 and FUS mislocalization in VCP mutant motor neurons is reversed by pharmacological inhibition of the VCP D2 ATPase domain.

Authors

Jasmine Harley, Cathleen Hagemann, Andrea Serio, Rickie Patani

TDP-43 and FUS mislocalization in VCP mutant motor neurons is reversed by pharmacological inhibition of the VCP D2 ATPase domain.

Am J Pathol

Published Jul 27, 2021

Interplay between Brain Pericytes and Endothelial Cells in Dementia.

Authors

Tessa V Procter, Anna Williams, Axel Montagne

Interplay between Brain Pericytes and Endothelial Cells in Dementia.

Nat Commun

Published Jul 23, 2021

Identifying individuals with high risk of Alzheimer's disease using polygenic risk scores.

Authors

Ganna Leonenko, Emily Baker, Joshua Stevenson-Hoare, Annerieke Sierksma, Mark Fiers, Julie Williams, Bart de Strooper, Valentina Escott-Price

Identifying individuals with high risk of Alzheimer's disease using polygenic risk scores.

Nucleic Acids Res

Published Jul 21, 2021

The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid-liquid phase separation.

Authors

Stefan Reber, Daniel Jutzi, Helen Lindsay, Anny Devoy, Jonas Mechtersheimer, Brunno Rocha Levone, Michal Domanski, Eva Bentmann, Dorothee Dormann, Oliver Mühlemann, Silvia M L Barabino, Marc-David Ruepp

The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid-liquid phase separation.

Sci Adv

Published Jul 08, 2021

FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation.

Authors

Nicol Birsa, Agnieszka M Ule, Maria Giovanna Garone, Brian Tsang, Francesca Mattedi, P Andrew Chong, Jack Humphrey, Seth Jarvis, Melis Pisiren, Oscar G Wilkins, Micheal L Nosella, Anny Devoy, Cristian Bodo, Rafaela Fernandez de la Fuente, Elizabeth M C Fisher, Alessandro Rosa, Gabriella Viero, Julie D Forman-Kay, Giampietro Schiavo, Pietro Fratta

FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation.

J Neurol Neurosurg Psychiatry

Published Jul 03, 2021

Neuroinflammation predicts disease progression in progressive supranuclear palsy.

Authors

Maura Malpetti, Luca Passamonti, Peter Simon Jones, Duncan Street, Timothy Rittman, Timothy D Fryer, Young T Hong, Patricia Vàsquez Rodriguez, William Richard Bevan-Jones, Franklin I Aigbirhio, John Tiernan O'Brien, James Benedict Rowe

Neuroinflammation predicts disease progression in progressive supranuclear palsy.

Physiol Rev

Published Jul 01, 2021

Do hippocampal pyramidal cells respond to nonspatial stimuli?

Authors

John O'Keefe, Julija Krupic

Do hippocampal pyramidal cells respond to nonspatial stimuli?

IEEE Trans Neural Syst Rehabil Eng

Published Jun 30, 2021

Quantification of Motor Function Post-Stroke Using Novel Combination of Wearable Inertial and Mechanomyographic Sensors.

Authors

Lewis Formstone, Weiguang Huo, Samuel Wilson, Alison McGregor, Paul Bentley, Ravi Vaidyanathan

Quantification of Motor Function Post-Stroke Using Novel Combination of Wearable Inertial and Mechanomyographic Sensors.

IEEE Trans Neural Syst Rehabil Eng

Published Jun 29, 2021

Wearable MMG-Plus-One Armband: Evaluation of Normal Force on Mechanomyography (MMG) to Enhance Human-Machine Interfacing.

Authors

C Sebastian Mancero Castillo, Samuel Wilson, Ravi Vaidyanathan, S Farokh Atashzar

Wearable MMG-Plus-One Armband: Evaluation of Normal Force on Mechanomyography (MMG) to Enhance Human-Machine Interfacing.

Curr Biol

Published Jun 07, 2021

Learning and memory: Scaling new areas.

Authors

Carola I Radulescu, Samuel J Barnes

Learning and memory: Scaling new areas.

Sci Transl Med

Published May 26, 2021

PAC1 receptor-mediated clearance of tau in postsynaptic compartments attenuates tau pathology in mouse brain.

Authors

Ari W Schaler, Avery M Runyan, Catherine L Clelland, Eric J Sydney, Stephanie L Fowler, Helen Y Figueroa, Seiji Shioda, Ismael Santa-Maria, Karen E Duff, Natura Myeku

PAC1 receptor-mediated clearance of tau in postsynaptic compartments attenuates tau pathology in mouse brain.

Mol Neurobiol

Published May 18, 2021

Novel Monoclonal Antibodies Against Mouse C1q: Characterisation and Development of a Quantitative ELISA for Mouse C1q.

Authors

Robert A J Byrne, Megan Torvell, Nikoleta Daskoulidou, Dina Fathalla, Eirini Kokkali, Sarah M Carpanini, B Paul Morgan

Novel Monoclonal Antibodies Against Mouse C1q: Characterisation and Development of a Quantitative ELISA for Mouse C1q.

Eur Stroke J

Published May 11, 2021

ESO Guideline on covert cerebral small vessel disease.

Authors

Joanna M Wardlaw, Stephanie Debette, Hanna Jokinen, Frank-Erik De Leeuw, Leonardo Pantoni, Hugues Chabriat, Julie Staals, Fergus Doubal, Salvatore Rudilosso, Sebastian Eppinger, Sabrina Schilling, Raffaele Ornello, Christian Enzinger, Charlotte Cordonnier, Martin Taylor-Rowan, Arne G Lindgren

ESO Guideline on covert cerebral small vessel disease.

Neurology

Published May 11, 2021

Timing and Impact of Psychiatric, Cognitive, and Motor Abnormalities in Huntington Disease.

Authors

Branduff McAllister, James F Gusella, G Bernhard Landwehrmeyer, Jong-Min Lee, Marcy E MacDonald, Michael Orth, Anne E Rosser, Nigel M Williams, Peter Holmans, Lesley Jones, Thomas H Massey,

Timing and Impact of Psychiatric, Cognitive, and Motor Abnormalities in Huntington Disease.

Cell Calcium

Published May 07, 2021

Multi-scale network imaging in a mouse model of amyloidosis.

Authors

Nazanin Doostdar, Joseph Airey, Carola I Radulescu, Leire Melgosa-Ecenarro, Nawal Zabouri, Pavlina Pavlidi, Maksym Kopanitsa, Takashi Saito, Takaomi Saido, Samuel J Barnes

Multi-scale network imaging in a mouse model of amyloidosis.

J Cell Biol

Published May 03, 2021

FUS-dependent liquid-liquid phase separation is important for DNA repair initiation.

Authors

Brunno R Levone, Silvia C Lenzken, Marco Antonaci, Andreas Maiser, Alexander Rapp, Francesca Conte, Stefan Reber, Jonas Mechtersheimer, Antonella E Ronchi, Oliver Mühlemann, Heinrich Leonhardt, M Cristina Cardoso, Marc-David Ruepp, Silvia M L Barabino

FUS-dependent liquid-liquid phase separation is important for DNA repair initiation.