Skip to main content
Search
Main content

Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Science advances
Published
Enhanced immunocompatibility and hemocompatibility of nanomedicines across multiple species using complement pathway inhibitors
Authors
Yue Li, Sarah Jacques, Hanmant Gaikwad, Morgan Nebbia, Nirmal K Banda, V Michael Holers, Stephen A Tomlinson, Robert I Scheinman, Andrew Monte, Laura Saba, Erika Lasda, Jay Hasselberth, Nicolas Busquet, Wioleta M Zelek, S Moein Moghimi, Dmitri Simberg
Enhanced immunocompatibility and hemocompatibility of nanomedicines across multiple species using complement pathway inhibitors
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Unravelling the plasma proteome: Pioneering biomarkers for differential dementia diagnosis
Authors
Haşim Gezegen, Merve Alaylıoğlu, Erdi Şahin, Owen Swann, Elena Veleva, Gamze Güven, Umran Yaman, Derviş A Salih, Başar Bilgiç, Haşmet Hanağası, Hakan Gürvit, Murat Emre, Duygu Gezen-Ak, Erdinç Dursun, Henrik Zetterberg, John Hardy, Amanda Heslegrave, Maryam Shoai, Bedia Samanci
Unravelling the plasma proteome: Pioneering biomarkers for differential dementia diagnosis
Stem cell reports
Published
Modeling common Alzheimer's disease with high and low polygenic risk in human iPSC: A large-scale research resource
Authors
Emily Maguire, Jincy Winston, Sarah H Ellwood, Rachel O'Donoghue, Bethany Shaw, Atahualpa Castillo Morales, Samuel Keat, Alexandra Evans, Rachel Marshall, Lauren Luckcuck, Laura Brown, Elisa Salis, Ganna Leonenko, Nicola Denning, EADB consortium, Nicholas D Allen, Valentina Escott-Price, Caleb Webber, Philip R Taylor, Rebecca Sims, Sally A Cowley, Julie Williams, Sarah M Carpanini, Hazel Hall-Roberts
Modeling common Alzheimer's disease with high and low polygenic risk in human iPSC: A large-scale research resource
Nature genetics
Published
The synthetic lethal interaction between CDS1 and CDS2 is a vulnerability in uveal melanoma and across multiple tumor types
Authors
Pui Ying Chan, Diana Alexander, Ishan Mehta, Larissa Satiko Alcantara Sekimoto Matsuyama, Victoria Harle, Rebeca Olvera-León, Jun Sung Park, Fernanda G Arriaga-González, Louise van der Weyden, Saamin Cheema, Vivek Iyer, Victoria Offord, David Barneda, Phillip T Hawkins, Len Stephens, Zuza Kozik, Michael Woods, Kim Wong, Gabriel Balmus, Alessandro Vinceti, Nicola A Thompson, Martin Del Castillo Velasco-Herrera, Lodewyk Wessels, Joris van de Haar, Emanuel Gonçalves, Sanju Sinha, Martha Estefania Vázquez-Cruz, Luisa Bisceglia, Francesco Raimondi, Jyoti Choudhary, Sumeet Patiyal, Anjan Venkatesh, Francesco Iorio, Colm J Ryan, David J Adams
The synthetic lethal interaction between CDS1 and CDS2 is a vulnerability in uveal melanoma and across multiple tumor types
Communications biology
Published
3BTRON: A Blood-Brain Barrier Recognition Network
Authors
Nan Fletcher-Lloyd, Isabel Bravo-Ferrer, Katrine Gaasdal-Bech, Blanca Díaz Castro, Payam Barnaghi
3BTRON: A Blood-Brain Barrier Recognition Network
Journal of Alzheimer's disease : JAD
Published
Accuracy of blood-based neurofilament light to different genetic frontotemporal dementia from primary psychiatric disorders
Authors
Ella Liu, Sherri Lee Jones, Victoria Light, Charlotte Teunissen, Arabella Bouzigues, Lucy L Russell, Phoebe H Foster, Eve Ferry-Bolder, John C van Swieten, Lize C Jiskoot, Harro Seelaar, Raquel Sanchez-Valle, Robert Laforce, Caroline Graff, Daniela Galimberti, Rik Vandenberghe, Alexandre de Mendonça, Pietro Tiraboschi, Isabel Santana, Alexander Gerhard, Johannes Levin, Sandro Sorbi, Markus Otto, Chris R Butler, Isabelle Le Ber, Elizabeth Finger, Maria Carmela Tartaglia, Mario Masellis, James B Rowe, Matthis Synofzik, Fermin Moreno, Barbara Borroni, Henrik Zetterberg, Jonathan D Rohrer, Simon Ducharme, Genetic Frontotemporal Dementia Initiative (GENFI) and Banque Signature (BbS)
Accuracy of blood-based neurofilament light to different genetic frontotemporal dementia from primary psychiatric disorders
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Genetically determined Alzheimer's disease research advances: The Down Syndrome & Autosomal Dominant Alzheimer's Disease 2024 Conference
Authors
Neus Falgàs, Lucia Maure-Blesa, Beau Ances, Lisi Flores-Aguilar, Sigan Hartley, Jason Hassenstab, M Florencia Iulita, Matthew Janicki, Katherine Koenig, Patrick Lao, Johannes Levin, Eric McDade, Laurent Meijer, Michael S Rafii, Heather M Snyder, Raquel Sánchez-Valle, Juan Fortea, DSAD‐ADAD conference group, Jose Arriola Infante, Mirea Balasa, Isabel Barroeta, Nicolas Barthelemy R, Alexandre Bejanin, Bessy Benejam, Beatriz Bosch, Angela Bradshaw, Maria Carmona-Iragui, Ann Cohen, Aina Comas Albertí, Lajos Csincsik, A Claudio Cuello, Laura Del Hoyo Soriano, Janna Dijkstra, Natalie Edwards, Sandra Giménez, Fernando Gonzalez-Ortiz, Brian Gordon, Sara Gutiérrez Fernández, Benjamin Handen, Charlotte Jacob, Erik Johnson, Charlotte Johansson, Albert Lladó, Alberto Lleó, Samuel Morabito, Alejandra O Morcillo-Nieto, Laia Montoliu-Gaya, Michael Okafor, Agnes Pérez-Millan, Marie Claude Potier, John Ringman, Íñigo Rodríguez-Baz, Eric Rubenstein, Natalie S Ryan, André Strydom, Lidia Vaqué-Alcázar, Lisa Vermunt, Laura Videla Toro, Shahid Zaman
Genetically determined Alzheimer's disease research advances: The Down Syndrome & Autosomal Dominant Alzheimer's Disease 2024 Conference
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Gut microbiome compositional and functional features associate with Alzheimer's disease pathology
Authors
Jea Woo Kang, Lora A Khatib, Margo B Heston, Amanda H Dilmore, Jennifer S Labus, Yuetiva Deming, Leyla Schimmel, Colette Blach, Daniel McDonald, Antonio Gonzalez, MacKenzie Bryant, Tyler K Ulland, Sterling C Johnson, Sanjay Asthana, Cynthia M Carlsson, Nathaniel A Chin, Kaj Blennow, Henrik Zetterberg, Federico E Rey, Alzheimer Gut Microbiome Project Consortium, Rima Kaddurah-Daouk, Rob Knight, Barbara B Bendlin
Gut microbiome compositional and functional features associate with Alzheimer's disease pathology
Lancet Healthy Longev
Published
Associations between life course exposure to ambient air pollution with cognition and later-life brain structure: a population-based study of the 1946 British Birth Cohort.
Authors
Thomas Canning, Jorge Arias-de la Torre, Helen L Fisher, John Gulliver, Anna L Hansell, Rebecca Hardy, Stephani L Hatch, Ian S Mudway, Amy Ronaldson, Molly Cartlidge, Sarah-Naomi James, Sarah E Keuss, Jonathan M Schott, Marcus Richards, Ioannis Bakolis
Associations between life course exposure to ambient air pollution with cognition and later-life brain structure: a population-based study of the 1946 British Birth Cohort.
Brain : a journal of neurology
Published
Brain health concerns in former rugby players: clinical and cognitive phenotypes
Authors
Thomas D Parker, Jessica A Hain, Erin J Rooney, Karl A Zimmerman, Ying Lee, Martina Del Giovane, Neil S N Graham, Maneesh Patel, Adam Hampshire, Mathew G Wilson, Daniel Friedland, David J Sharp, Richard J Sylvester
Brain health concerns in former rugby players: clinical and cognitive phenotypes
Nature communications
Published
Glial reactivity correlates with synaptic dysfunction across aging and Alzheimer's disease
Authors
Francieli Rohden, Pamela C L Ferreira, Bruna Bellaver, João Pedro Ferrari-Souza, Cristiano S Aguzzoli, Carolina Soares, Sarah Abbas, Hussein Zalzale, Guilherme Povala, Firoza Z Lussier, Douglas T Leffa, Guilherme Bauer-Negrini, Nesrine Rahmouni, Cécile Tissot, Joseph Therriault, Stijn Servaes, Jenna Stevenson, Andrea L Benedet, Nicholas J Ashton, Thomas K Karikari, Dana L Tudorascu, Henrik Zetterberg, Kaj Blennow, Eduardo R Zimmer, Diogo Souza, Pedro Rosa-Neto, Tharick A Pascoal
Glial reactivity correlates with synaptic dysfunction across aging and Alzheimer's disease
Nature communications
Published
Abstraction hierarchy to define biofoundry workflows and operations for interoperable synthetic biology research and applications
Authors
Haseong Kim, Nathan J Hillson, Byung-Kwan Cho, Bong Hyun Sung, Dae-Hee Lee, Dong-Myung Kim, Min-Kyu Oh, Matthew Wook Chang, Yong-Su Jin, Susan J Rosser, Peter Vegh, Rennos Fragkoudis, Rosalind Le Feuvre, Nigel S Scrutton, Marko Storch, Wonjae Seong, Paul S Freemont, Seung-Goo Lee
Abstraction hierarchy to define biofoundry workflows and operations for interoperable synthetic biology research and applications
Nature communications
Published
Proteomic analysis of Down syndrome cerebrospinal fluid compared to late-onset and autosomal dominant Alzheimer´s disease
Authors
Laia Montoliu-Gaya, Shijia Bian, Eric B Dammer, Daniel Alcolea, Mathias Sauer, Mitchell Martá-Ariza, Nicholas J Ashton, Olivia Belbin, Johannes Fuchs, Caroline M Watson, Lingyan Ping, Duc M Duong, Johanna Nilsson, Isabel Barroeta, Juan Lantero-Rodriguez, Laura Videla, Bessy Benejam, Blaine R Roberts, Kaj Blennow, Nicholas T Seyfried, Allan I Levey, María Carmona-Iragui, Johan Gobom, Alberto Lleó, Thomas Wisniewski, Henrik Zetterberg, Juan Fortea, Erik C B Johnson
Proteomic analysis of Down syndrome cerebrospinal fluid compared to late-onset and autosomal dominant Alzheimer´s disease