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Jan 17, 2025 - Research

Brain changes in Huntington’s disease occur decades before diagnosis

Subtle changes in the brain happen approximately twenty years before a clinical motor diagnosis in people with Huntington’s disease, finds a new study led by...

Learn more Brain changes in Huntington’s disease occur decades before diagnosis

Jan 08, 2025 - Research

Genetic changes in brain cells link ageing and Alzheimer’s

Genetic differences that contribute to how long a person will live and their risk of Alzheimer’s disease have been identified in a new study led...

Learn more Genetic changes in brain cells link ageing and Alzheimer’s

Phospho-tau accumulation in MAPT knockout mice

Jan 08, 2025 - Research

Brain damage starts before tau protein clumps in frontotemporal dementia and Alzheimer’s

A new study led by Prof Karen Duff, Dr Naoto Watamura, and Dr Martha Foiani (UK DRI at UCL), with Prof Takaomi Saido (Riken Center...

Learn more Brain damage starts before tau protein clumps in frontotemporal dementia and Alzheimer’s

Lancet Neurol

Published Dec 01, 2016

Clinical phenotype and genetic associations in autosomal dominant familial Alzheimer's disease: a case series.

Authors

Natalie S Ryan, Jennifer M Nicholas, Philip S J Weston, Yuying Liang, Tammaryn Lashley, Rita Guerreiro, Gary Adamson, Janna Kenny, Jon Beck, Lucia Chavez-Gutierrez, Bart de Strooper, Tamas Revesz, Janice Holton, Simon Mead, Martin N Rossor, Nick C Fox

Clinical phenotype and genetic associations in autosomal dominant familial Alzheimer's disease: a case series.

Nat Commun

Published Nov 09, 2016

Contracting CAG/CTG repeats using the CRISPR-Cas9 nickase.

Authors

Cinzia Cinesi, Lorène Aeschbach, Bin Yang, Vincent Dion

Contracting CAG/CTG repeats using the CRISPR-Cas9 nickase.

Neurology

Published Nov 08, 2016

Presymptomatic cortical thinning in familial Alzheimer disease: A longitudinal MRI study.

Authors

Philip S J Weston, Jennifer M Nicholas, Manja Lehmann, Natalie S Ryan, Yuying Liang, Kirsty Macpherson, Marc Modat, Martin N Rossor, Jonathan M Schott, Sebastien Ourselin, Nick C Fox

Presymptomatic cortical thinning in familial Alzheimer disease: A longitudinal MRI study.

Genes Dev

Published Oct 01, 2016

Synthetic lethality between PAXX and XLF in mammalian development.

Authors

Gabriel Balmus, Ana C Barros, Paul W G Wijnhoven, Chloé Lescale, Hélène Lenden Hasse, Katharina Boroviak, Carlos le Sage, Brendan Doe, Anneliese O Speak, Antonella Galli, Matt Jacobsen, Ludovic Deriano, David J Adams, Andrew N Blackford, Stephen P Jackson

Synthetic lethality between PAXX and XLF in mammalian development.

Mol Neurodegener

Published Sep 29, 2016

Cerebrospinal fluid Presenilin-1 increases at asymptomatic stage in genetically determined Alzheimer's disease.

Authors

Aitana Sogorb-Esteve, María-Salud García-Ayllón, Juan Fortea, Raquel Sánchez-Valle, Alberto Lleó, José-Luis Molinuevo, Javier Sáez-Valero

Cerebrospinal fluid Presenilin-1 increases at asymptomatic stage in genetically determined Alzheimer's disease.

Nat Neurosci

Published Aug 01, 2016

Neuronal activity enhances tau propagation and tau pathology in vivo.

Authors

Jessica W Wu, S Abid Hussaini, Isle M Bastille, Gustavo A Rodriguez, Ana Mrejeru, Kelly Rilett, David W Sanders, Casey Cook, Hongjun Fu, Rick A C M Boonen, Mathieu Herman, Eden Nahmani, Sheina Emrani, Y Helen Figueroa, Marc I Diamond, Catherine L Clelland, Selina Wray, Karen E Duff

Neuronal activity enhances tau propagation and tau pathology in vivo.

Lancet

Published Jul 30, 2016

Alzheimer's disease.

Authors

Philip Scheltens, Kaj Blennow, Monique M B Breteler, Bart de Strooper, Giovanni B Frisoni, Stephen Salloway, Wiesje Maria Van der Flier

Alzheimer's disease.

Nat Neurosci

Published Jul 18, 2016

Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior.

Authors

Alexi Nott, Jemmie Cheng, Fan Gao, Yuan-Ta Lin, Elizabeta Gjoneska, Tak Ko, Paras Minhas, Alicia Viridiana Zamudio, Jia Meng, Feiran Zhang, Peng Jin, Li-Huei Tsai

Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior.

EMBO J

Published Jul 15, 2016

Minor intron splicing is regulated by FUS and affected by ALS-associated FUS mutants.

Authors

Stefan Reber, Jolanda Stettler, Giuseppe Filosa, Martino Colombo, Daniel Jutzi, Silvia C Lenzken, Christoph Schweingruber, Rémy Bruggmann, Angela Bachi, Silvia Ml Barabino, Oliver Mühlemann, Marc-David Ruepp

Minor intron splicing is regulated by FUS and affected by ALS-associated FUS mutants.

Mol Neurodegener

Published Jun 10, 2016

Synaptophysin depletion and intraneuronal Aβ in organotypic hippocampal slice cultures from huAPP transgenic mice.

Authors

Claire S Harwell, Michael P Coleman

Synaptophysin depletion and intraneuronal Aβ in organotypic hippocampal slice cultures from huAPP transgenic mice.

Science

Published May 06, 2016

Complement and microglia mediate early synapse loss in Alzheimer mouse models.

Authors

Soyon Hong, Victoria F Beja-Glasser, Bianca M Nfonoyim, Arnaud Frouin, Shaomin Li, Saranya Ramakrishnan, Katherine M Merry, Qiaoqiao Shi, Arnon Rosenthal, Ben A Barres, Cynthia A Lemere, Dennis J Selkoe, Beth Stevens

Complement and microglia mediate early synapse loss in Alzheimer mouse models.

Neuron

Published Apr 20, 2016

Familial Alzheimer's Disease Mutations in Presenilin Generate Amyloidogenic Aβ Peptide Seeds.

Authors

Sarah Veugelen, Takashi Saito, Takaomi C Saido, Lucía Chávez-Gutiérrez, Bart De Strooper

Familial Alzheimer's Disease Mutations in Presenilin Generate Amyloidogenic Aβ Peptide Seeds.

Proc Natl Acad Sci U S A

Published Apr 12, 2016

S-nitrosation of proteins relevant to Alzheimer's disease during early stages of neurodegeneration.

Authors

Uthpala Seneviratne, Alexi Nott, Vadiraja B Bhat, Kodihalli C Ravindra, John S Wishnok, Li-Huei Tsai, Steven R Tannenbaum

S-nitrosation of proteins relevant to Alzheimer's disease during early stages of neurodegeneration.

Trends Neurosci

Published Mar 01, 2016

BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease.

Authors

Soraia Barão, Diederik Moechars, Stefan F Lichtenthaler, Bart De Strooper

BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease.

Cell

Published Feb 11, 2016

The Cellular Phase of Alzheimer's Disease.

Authors

Bart De Strooper, Eric Karran

The Cellular Phase of Alzheimer's Disease.

Front Neurosci

Published Jan 27, 2016

Identification of Vulnerable Cell Types in Major Brain Disorders Using Single Cell Transcriptomes and Expression Weighted Cell Type Enrichment.

Authors

Nathan G Skene, Seth G N Grant

Identification of Vulnerable Cell Types in Major Brain Disorders Using Single Cell Transcriptomes and Expression Weighted Cell Type Enrichment.

Nat Neurosci

Published Jan 18, 2016

Microglial brain region-dependent diversity and selective regional sensitivities to aging.

Authors

Kathleen Grabert, Tom Michoel, Michail H Karavolos, Sara Clohisey, J Kenneth Baillie, Mark P Stevens, Tom C Freeman, Kim M Summers, Barry W McColl

Microglial brain region-dependent diversity and selective regional sensitivities to aging.

Nat Med

Published Dec 21, 2015

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling.

Authors

Natura Myeku, Catherine L Clelland, Sheina Emrani, Nikolay V Kukushkin, Wai Haung Yu, Alfred L Goldberg, Karen E Duff

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling.