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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Schizophr Res
Published

Complement system biomarkers in first episode psychosis.

Authors
Maja Kopczynska, Wioleta Zelek, Samuel Touchard, Fiona Gaughran, Marta Di Forti, Valeria Mondelli, Robin Murray, Michael C O'Donovan, B Paul Morgan
Complement system biomarkers in first episode psychosis.
Mol Cell
Published

Structure of the AAA ATPase p97.

Authors
X Zhang, A Shaw, P A Bates, R H Newman, B Gowen, E Orlova, M A Gorman, H Kondo, P Dokurno, J Lally, G Leonard, H Meyer, M van Heel, P S Freemont
Structure of the AAA ATPase p97.
Acta Neuropathol
Published

PolyGA targets the ER stress-adaptive response by impairing GRP75 function at the MAM in C9ORF72-ALS/FTD.

Authors
Federica Pilotto, Alexander Schmitz, Niran Maharjan, Rim Diab, Adolfo Odriozola, Priyanka Tripathi, Alfred Yamoah, Olivier Scheidegger, Angelina Oestmann, Cassandra N Dennys, Shrestha Sinha Ray, Rochelle Rodrigo, Stephen Kolb, Eleonora Aronica, Stefano Di Santo, Hans Rudolf Widmer, Nicolas Charlet-Berguerand, Bhuvaneish T Selvaraj, Siddharthan Chandran, Kathrin Meyer, Benoît Zuber, Anand Goswami, Joachim Weis, Smita Saxena
PolyGA targets the ER stress-adaptive response by impairing GRP75 function at the MAM in C9ORF72-ALS/FTD.
Nat Med
Published

Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease.

Authors
Marie-Gabrielle Duperron, Maria J Knol, Quentin Le Grand, Tavia E Evans, Aniket Mishra, Ami Tsuchida, Gennady Roshchupkin, Takahiro Konuma, David-Alexandre Trégouët, Jose Rafael Romero, Stefan Frenzel, Michelle Luciano, Edith Hofer, Mathieu Bourgey, Nicole D Dueker, Pilar Delgado, Saima Hilal, Rick M Tankard, Florian Dubost, Jean Shin, Yasaman Saba, Nicola J Armstrong, Constance Bordes, Mark E Bastin, Alexa Beiser, Henry Brodaty, Robin Bülow, Caty Carrera, Christopher Chen, Ching-Yu Cheng, Ian J Deary, Piyush G Gampawar, Jayandra J Himali, Jiyang Jiang, Takahisa Kawaguchi, Shuo Li, Melissa Macalli, Pascale Marquis, Zoe Morris, Susana Muñoz Maniega, Susumu Miyamoto, Masakazu Okawa, Matthew Paradise, Pedram Parva, Tatjana Rundek, Muralidharan Sargurupremraj, Sabrina Schilling, Kazuya Setoh, Omar Soukarieh, Yasuharu Tabara, Alexander Teumer, Anbupalam Thalamuthu, Julian N Trollor, Maria C Valdés Hernández, Meike W Vernooij, Uwe Völker, Katharina Wittfeld, Tien Yin Wong, Margaret J Wright, Junyi Zhang, Wanting Zhao, Yi-Cheng Zhu, Helena Schmidt, Perminder S Sachdev, Wei Wen, Kazumichi Yoshida, Anne Joutel, Claudia L Satizabal, Ralph L Sacco, Guillaume Bourque, , Mark Lathrop, Tomas Paus, Israel Fernandez-Cadenas, Qiong Yang, Bernard Mazoyer, Philippe Boutinaud, Yukinori Okada, Hans J Grabe, Karen A Mather, Reinhold Schmidt, Marc Joliot, M Arfan Ikram, Fumihiko Matsuda, Christophe Tzourio, Joanna M Wardlaw, Sudha Seshadri, Hieab H H Adams, Stéphanie Debette
Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease.
Lancet Neurol
Published

Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration.

Authors
Joanna M Wardlaw, Eric E Smith, Geert J Biessels, Charlotte Cordonnier, Franz Fazekas, Richard Frayne, Richard I Lindley, John T O'Brien, Frederik Barkhof, Oscar R Benavente, Sandra E Black, Carol Brayne, Monique Breteler, Hugues Chabriat, Charles Decarli, Frank-Erik de Leeuw, Fergus Doubal, Marco Duering, Nick C Fox, Steven Greenberg, Vladimir Hachinski, Ingo Kilimann, Vincent Mok, Robert van Oostenbrugge, Leonardo Pantoni, Oliver Speck, Blossom C M Stephan, Stefan Teipel, Anand Viswanathan, David Werring, Christopher Chen, Colin Smith, Mark van Buchem, Bo Norrving, Philip B Gorelick, Martin Dichgans,
Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration.
Mov Disord
Published

Embedding Patient Input in Outcome Measures for Long-Term Disease-Modifying Parkinson Disease Trials.

Authors
Cristina Gonzalez-Robles, Michèle Bartlett, Matthew Burnell, Caroline S Clarke, Shlomi Haar, Michele T Hu, Brook Huxford, Ashwani Jha, Michael Lawton, Alastair Noyce, Paola Piccini, Kuhan Pushparatnam, Lynn Rochester, Carroll Siu, Daniel van Wamelen, Caroline H Williams-Gray, Marie-Louise Zeissler, Henrik Zetterberg, Camille B Carroll, Thomas Foltynie, Rimona S Weil, Anette Schrag,
Embedding Patient Input in Outcome Measures for Long-Term Disease-Modifying Parkinson Disease Trials.
Intensive Care Med
Published

Natural history, trajectory, and management of mechanically ventilated COVID-19 patients in the United Kingdom.

Authors
Brijesh V Patel, Shlomi Haar, Rhodri Handslip, Chaiyawan Auepanwiriyakul, Teresa Mei-Ling Lee, Sunil Patel, J Alex Harston, Feargus Hosking-Jervis, Donna Kelly, Barnaby Sanderson, Barbara Borgatta, Kate Tatham, Ingeborg Welters, Luigi Camporota, Anthony C Gordon, Matthieu Komorowski, David Antcliffe, John R Prowle, Zudin Puthucheary, Aldo A Faisal,
Natural history, trajectory, and management of mechanically ventilated COVID-19 patients in the United Kingdom.
Cereb Cortex
Published

Anatomical Abnormalities in Autism?

Authors
Shlomi Haar, Sigal Berman, Marlene Behrmann, Ilan Dinstein
Anatomical Abnormalities in Autism?
Nat Biomed Eng
Published

Closed-loop optogenetic control of the dynamics of neural activity in non-human primates.

Authors
B Zaaimi, M Turnbull, A Hazra, Y Wang, C Gandara, F McLeod, E E McDermott, E Escobedo-Cousin, A Shah Idil, R G Bailey, S Tardio, A Patel, N Ponon, J Gausden, D Walsh, F Hutchings, M Kaiser, M O Cunningham, G J Clowry, F E N LeBeau, T G Constandinou, S N Baker, N Donaldson, P Degenaar, A O'Neill, A J Trevelyan, A Jackson
Closed-loop optogenetic control of the dynamics of neural activity in non-human primates.
EClinicalMedicine
Published

Changes in memory and cognition during the SARS-CoV-2 human challenge study.

Authors
William Trender, Peter J Hellyer, Ben Killingley, Mariya Kalinova, Alex J Mann, Andrew P Catchpole, David Menon, Edward Needham, Ryan Thwaites, Christopher Chiu, Gregory Scott, Adam Hampshire
Changes in memory and cognition during the SARS-CoV-2 human challenge study.