Publications

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Jan 17, 2025 - Research

Brain changes in Huntington’s disease occur decades before diagnosis

Subtle changes in the brain happen approximately twenty years before a clinical motor diagnosis in people with Huntington’s disease, finds a new study led by...

Learn more Brain changes in Huntington’s disease occur decades before diagnosis

Jan 08, 2025 - Research

Genetic changes in brain cells link ageing and Alzheimer’s

Genetic differences that contribute to how long a person will live and their risk of Alzheimer’s disease have been identified in a new study led...

Learn more Genetic changes in brain cells link ageing and Alzheimer’s

Phospho-tau accumulation in MAPT knockout mice

Jan 08, 2025 - Research

Brain damage starts before tau protein clumps in frontotemporal dementia and Alzheimer’s

A new study led by Prof Karen Duff, Dr Naoto Watamura, and Dr Martha Foiani (UK DRI at UCL), with Prof Takaomi Saido (Riken Center...

Learn more Brain damage starts before tau protein clumps in frontotemporal dementia and Alzheimer’s

Brain

Published Jul 18, 2013

The role of the posterior cingulate cortex in cognition and disease.

Authors

Robert Leech, David J Sharp

The role of the posterior cingulate cortex in cognition and disease.

Nat Commun

Published May 21, 2013

Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation.

Authors

Luke C Davies, Marcela Rosas, Stephen J Jenkins, Chia-Te Liao, Martin J Scurr, Frank Brombacher, Donald J Fraser, Judith E Allen, Simon A Jones, Philip R Taylor

Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation.

J Cell Biol

Published Apr 15, 2013

Lifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redox.

Authors

Edward Avezov, Benedict C S Cross, Gabriele S Kaminski Schierle, Mikael Winters, Heather P Harding, Eduardo Pinho Melo, Clemens F Kaminski, David Ron

Lifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redox.

N Engl J Med

Published Jan 10, 2013

TREM2 variants in Alzheimer's disease.

Authors

Rita Guerreiro, Aleksandra Wojtas, Jose Bras, Minerva Carrasquillo, Ekaterina Rogaeva, Elisa Majounie, Carlos Cruchaga, Celeste Sassi, John S K Kauwe, Steven Younkin, Lilinaz Hazrati, John Collinge, Jennifer Pocock, Tammaryn Lashley, Julie Williams, Jean-Charles Lambert, Philippe Amouyel, Alison Goate, Rosa Rademakers, Kevin Morgan, John Powell, Peter St George-Hyslop, Andrew Singleton, John Hardy,

TREM2 variants in Alzheimer's disease.

Nature

Published Dec 13, 2012

Ubiquitin chain conformation regulates recognition and activity of interacting proteins.

Authors

Yu Ye, Georg Blaser, Mathew H Horrocks, Maria J Ruedas-Rama, Shehu Ibrahim, Alexander A Zhukov, Angel Orte, David Klenerman, Sophie E Jackson, David Komander

Ubiquitin chain conformation regulates recognition and activity of interacting proteins.

Hum Mol Genet

Published Aug 01, 2012

Disease severity in a mouse model of ataxia telangiectasia is modulated by the DNA damage checkpoint gene Hus1.

Authors

Gabriel Balmus, Min Zhu, Sucheta Mukherjee, Amy M Lyndaker, Kelly R Hume, Jaesung Lee, Mark L Riccio, Anthony P Reeves, Nathan B Sutter, Drew M Noden, Rachel M Peters, Robert S Weiss

Disease severity in a mouse model of ataxia telangiectasia is modulated by the DNA damage checkpoint gene Hus1.

Brain

Published Jul 13, 2012

Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β.

Authors

Robert M Koffie, Tadafumi Hashimoto, Hwan-Ching Tai, Kevin R Kay, Alberto Serrano-Pozo, Daniel Joyner, Steven Hou, Katherine J Kopeikina, Matthew P Frosch, Virginia M Lee, David M Holtzman, Bradley T Hyman, Tara L Spires-Jones

Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β.

Lancet

Published Jun 23, 2012

Recombinant tissue plasminogen activator for acute ischaemic stroke: an updated systematic review and meta-analysis.

Authors

Joanna M Wardlaw, Veronica Murray, Eivind Berge, Gregory del Zoppo, Peter Sandercock, Richard L Lindley, Geoff Cohen

Recombinant tissue plasminogen activator for acute ischaemic stroke: an updated systematic review and meta-analysis.

Cell

Published May 25, 2012

Direct observation of the interconversion of normal and toxic forms of α-synuclein.

Authors

Nunilo Cremades, Samuel I A Cohen, Emma Deas, Andrey Y Abramov, Allen Y Chen, Angel Orte, Massimo Sandal, Richard W Clarke, Paul Dunne, Francesco A Aprile, Carlos W Bertoncini, Nicholas W Wood, Tuomas P J Knowles, Christopher M Dobson, David Klenerman

Direct observation of the interconversion of normal and toxic forms of α-synuclein.

Nat Cell Biol

Published Apr 08, 2012

Increased mobility of double-strand breaks requires Mec1, Rad9 and the homologous recombination machinery.

Authors

Vincent Dion, Véronique Kalck, Chihiro Horigome, Benjamin D Towbin, Susan M Gasser

Increased mobility of double-strand breaks requires Mec1, Rad9 and the homologous recombination machinery.

Nat Neurosci

Published Jan 29, 2012

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes.

Authors

Iryna Benilova, Eric Karran, Bart De Strooper

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes.

Nat Struct Mol Biol

Published Dec 18, 2011

The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β(1-40) peptide.

Authors

Priyanka Narayan, Angel Orte, Richard W Clarke, Benedetta Bolognesi, Sharon Hook, Kristina A Ganzinger, Sarah Meehan, Mark R Wilson, Christopher M Dobson, David Klenerman

The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β(1-40) peptide.

IEEE Int Conf Rehabil Robot

Published Jul 01, 2011

Estimation of IMU and MARG orientation using a gradient descent algorithm.

Authors

Sebastian O H Madgwick, Andrew J L Harrison, Andrew Vaidyanathan

Estimation of IMU and MARG orientation using a gradient descent algorithm.

Ann Neurol

Published Apr 18, 2011

Inflammation after trauma: microglial activation and traumatic brain injury.

Authors

Anil F Ramlackhansingh, David J Brooks, Richard J Greenwood, Subrata K Bose, Federico E Turkheimer, Kirsi M Kinnunen, Steve Gentleman, Rolf A Heckemann, Karen Gunanayagam, Giorgio Gelosa, David J Sharp

Inflammation after trauma: microglial activation and traumatic brain injury.

J Neurosci

Published Mar 02, 2011

Fractionating the default mode network: distinct contributions of the ventral and dorsal posterior cingulate cortex to cognitive control.

Authors

Robert Leech, Salwa Kamourieh, Christian F Beckmann, David J Sharp

Fractionating the default mode network: distinct contributions of the ventral and dorsal posterior cingulate cortex to cognitive control.

IEEE Trans Biomed Eng

Published Feb 14, 2011

Modeling study of the light stimulation of a neuron cell with channelrhodopsin-2 mutants.

Authors

Nir Grossman, Konstantin Nikolic, Christofer Toumazou, Patrick Degenaar

Modeling study of the light stimulation of a neuron cell with channelrhodopsin-2 mutants.

Brain

Published Dec 30, 2010

White matter damage and cognitive impairment after traumatic brain injury.

Authors

Kirsi Maria Kinnunen, Richard Greenwood, Jane Hilary Powell, Robert Leech, Peter Charlie Hawkins, Valerie Bonnelle, Maneesh Chandrakant Patel, Serena Jane Counsell, David James Sharp

White matter damage and cognitive impairment after traumatic brain injury.

Neuron

Published Jul 29, 2010

CaMKII triggers the diffusional trapping of surface AMPARs through phosphorylation of stargazin.

Authors

Patricio Opazo, Simon Labrecque, Cezar M Tigaret, Arnaud Frouin, Paul W Wiseman, Paul De Koninck, Daniel Choquet

CaMKII triggers the diffusional trapping of surface AMPARs through phosphorylation of stargazin.