Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

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Cytokines released by T cells after encountering cancer cells

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system
Acta neuropathologica communications
Published
Mapping the glial transcriptome in Huntington's disease using snRNAseq: selective disruption of glial signatures across brain regions
Authors
Sunniva M K Bøstrand, Luise A Seeker, Nadine Bestard-Cuche, Nina-Lydia Kazakou, Sarah Jäkel, Boyd Kenkhuis, Neil C Henderson, Susanne T de Bot, Willeke M C van Roon-Mom, Josef Priller, Anna Williams
Mapping the glial transcriptome in Huntington's disease using snRNAseq: selective disruption of glial signatures across brain regions
Alzheimer's research & therapy
Published
Plasma neurofilament light chain as prognostic marker of cognitive decline in neurodegenerative diseases, a clinical setting study
Authors
Karl Götze, Agathe Vrillon, Julien Dumurgier, Sandrine Indart, Marta Sanchez-Ortiz, Hela Slimi, Agathe Raynaud-Simon, Emmanuel Cognat, Matthieu Martinet, Henrik Zetterberg, Kaj Blennow, Claire Hourrègue, Elodie Bouaziz-Amar, Claire Paquet, Matthieu Lilamand
Plasma neurofilament light chain as prognostic marker of cognitive decline in neurodegenerative diseases, a clinical setting study
Brain : a journal of neurology
Published
Associations between accelerated forgetting, amyloid deposition and brain atrophy in older adults
Authors
Kirsty Lu, John Baker, Jennifer M Nicholas, Rebecca E Street, Sarah E Keuss, William Coath, Sarah-Naomi James, Ashvini Keshavan, Philip S J Weston, Heidi Murray-Smith, David M Cash, Ian B Malone, Andrew Wong, Nick C Fox, Marcus Richards, Sebastian J Crutch, Jonathan M Schott
Associations between accelerated forgetting, amyloid deposition and brain atrophy in older adults
The Lancet. Neurology
Published
Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial
Authors
Keith W Muir, Gary A Ford, Ian Ford, Joanna M Wardlaw, Alex McConnachie, Nicola Greenlaw, Grant Mair, Nikola Sprigg, Christopher I Price, Mary Joan MacLeod, Sofia Dima, Marius Venter, Liqun Zhang, Eoin O'Brien, Ranjan Sanyal, John Reid, Laszlo K Sztriha, Syed Haider, William N Whiteley, James Kennedy, Richard Perry, Sekaran Lakshmanan, Annie Chakrabarti, Ahamad Hassan, Richard Marigold, Senthil Raghunathan, Don Sims, Mohit Bhandari, Ivan Wiggam, Khalid Rashed, Chris Douglass, ATTEST-2 Investigators
Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial
Journal of the American Heart Association
Published
Choroid Plexus Volume in Rural Chinese Older Adults: Distribution and Association With Cardiovascular Risk Factors and Cerebral Small Vessel Disease
Authors
Chunyan Li, Huisi Zhang, Jiafeng Wang, Xiaodong Han, Cuicui Liu, Yuanjing Li, Tao Gong, Tingting Hou, Yongxiang Wang, Lin Cong, Grégoria Kalpouzos, Joanna Wardlaw, Lin Song, Yifeng Du, Chengxuan Qiu
Choroid Plexus Volume in Rural Chinese Older Adults: Distribution and Association With Cardiovascular Risk Factors and Cerebral Small Vessel Disease
medRxiv : the preprint server for health sciences
Published
Genome-wide scan of Flortaucipir PET levels finds <em>JARID2</em> associated with cerebral tau deposition
Authors
Tamil Iniyan Gunasekaran, Devendra Meena, Annie J Lee, Siwei Wu, Logan Dumitrescu, Reisa Sperling, Timothy J Hohman, Alzheimer’s Disease Neuroimaging Initiative, A4 Study, Jingxian Huang, Abbas Dehghan, Ioanna Tzoulaki, Richard Mayeux, Badri Vardarajan
Genome-wide scan of Flortaucipir PET levels finds <em>JARID2</em> associated with cerebral tau deposition
bioRxiv : the preprint server for biology
Published
Isotope Encoded chemical Imaging Identifies Amyloid Plaque Age Dependent Structural Maturation, Synaptic Loss, and Increased Toxicity
Authors
Jack I Wood, Maciej Dulewicz, Junyue Ge, Katie Stringer, Alicja Szadziewska, Sneha Desai, Srinivas Koutarapu, Haady B Hajar, Kaj Blennow, Henrik Zetterberg, Damian M Cummings, Jeffrey N Savas, Frances A Edwards, Jörg Hanrieder
Isotope Encoded chemical Imaging Identifies Amyloid Plaque Age Dependent Structural Maturation, Synaptic Loss, and Increased Toxicity
Neuron
Published
Autophagy, aging, and age-related neurodegeneration
Authors
Jennifer E Palmer, Niall Wilson, Sung Min Son, Pawel Obrocki, Lidia Wrobel, Matea Rob, Michael Takla, Viktor I Korolchuk, David C Rubinsztein
Autophagy, aging, and age-related neurodegeneration
JAMA network open
Published
Sex Differences in Frequency, Severity, and Distribution of Cerebral Microbleeds
Authors
Simon Fandler-Höfler, Sebastian Eppinger, Gareth Ambler, Philip Nash, Markus Kneihsl, Keon-Joo Lee, Jae-Sung Lim, Masayuki Shiozawa, Masatoshi Koga, Linxin Li, Caroline Lovelock, Hugues Chabriat, Michael Hennerici, Yuen Kwun Wong, Henry Ka Fung Mak, Luis Prats-Sanchez, Alejandro Martínez-Domeño, Shigeru Inamura, Kazuhisa Yoshifuji, Ethem Murat Arsava, Solveig Horstmann, Jan Purrucker, Bonnie Yin Ka Lam, Adrian Wong, Young Dae Kim, Tae-Jin Song, Robin Lemmens, Ender Uysal, Zeynep Tanriverdi, Natan M Bornstein, Einor Ben Assayag, Hen Hallevi, Jeremy Molad, Masashi Nishihara, Jun Tanaka, Shelagh B Coutts, Alexandros Polymeris, Benjamin Wagner, David J Seiffge, Philippe Lyrer, L Jaap Kappelle, Rustam Al-Shahi Salman, Maria Valdes Hernandez, Hans R Jäger, Gregory Y H Lip, Urs Fischer, Marwan El-Koussy, Jean-Louis Mas, Laurence Legrand, Christopher Karayiannis, Thanh Phan, Sarah Gunkel, Nicolas Christ, Jill Abrigo, Winnie Chu, Thomas Leung, Francesca Chappell, Stephen Makin, Derek Hayden, David J Williams, Werner H Mess, M Eline Kooi, Carmen Barbato, Simone Browning, Anil M Tuladhar, Noortje Maaijwee, Anne Cristine Guevarra, Anne-Marie Mendyk, Christine Delmaire, Sebastian Köhler, Robert van Oostenbrugge, Ying Zhou, Chao Xu, Saima Hilal, Caroline Robert, Christopher Chen, Min Lou, Julie Staals, Régis Bordet, Nagaendran Kandiah, Frank-Erik de Leeuw, Robert Simister, Daniel Bos, Peter J Kelly, Joanna Wardlaw, Yannie Soo, Felix Fluri, Velandai Srikanth, David Calvet, Simon Jung, Vincent I H Kwa, Stefan T Engelter, Nils Peters, Eric E Smith, Hideo Hara, Yusuke Yakushiji, Dilek Necioglu Orken, Vincent Thijs, Ji Hoe Heo, Vincent Mok, Roland Veltkamp, Hakan Ay, Toshio Imaizumi, Kui Kai Lau, Eric Jouvent, Peter M Rothwell, Kazunori Toyoda, Hee-Joon Bae, Joan Marti-Fabregas, Duncan Wilson, Jonathan Best, Franz Fazekas, Christian Enzinger, David J Werring, Thomas Gattringer, Microbleeds International Collaborative Network
Sex Differences in Frequency, Severity, and Distribution of Cerebral Microbleeds
Clinical chemistry and laboratory medicine
Published
The correlation of albumin with total protein concentrations in cerebrospinal fluid across three automated analysers - relevance to the diagnosis of subarachnoid haemorrhage in clinical chemistry practice
Authors
Marcus Clarin, Elin Gustafsson, Carina Gustafsson, Maria Lohmander, Henrik Zetterberg
The correlation of albumin with total protein concentrations in cerebrospinal fluid across three automated analysers - relevance to the diagnosis of subarachnoid haemorrhage in clinical chemistry practice
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Head-to-head comparison of leading blood tests for Alzheimer's disease pathology
Authors
Suzanne E Schindler, Kellen K Petersen, Benjamin Saef, Duygu Tosun, Leslie M Shaw, Henrik Zetterberg, Jeffrey L Dage, Kyle Ferber, Gallen Triana-Baltzer, Lei Du-Cuny, Yan Li, Janaky Coomaraswamy, Michael Baratta, Yulia Mordashova, Ziad S Saad, David L Raunig, Nicholas J Ashton, Emily A Meyers, Carrie E Rubel, Erin G Rosenbaugh, Anthony W Bannon, William Z Potter, Alzheimer's Disease Neuroimaging Initiative (ADNI) Foundation for the National Institutes of Health (FNIH) Biomarkers Consortium Plasma Aβ and Phosphorylated Tau as Predictors of Amyloid and Tau Positivity in Alzheimer's Disease Project Team
Head-to-head comparison of leading blood tests for Alzheimer's disease pathology
Journal of neurology, neurosurgery, and psychiatry
Published
Poor long-term outcomes and abnormal neurodegeneration biomarkers after military traumatic brain injury: the ADVANCE study
Authors
Neil Sn Graham, Grace Blissitt, Karl Zimmerman, Lydia Orton, Daniel Friedland, Emma Coady, Rhiannon Laban, Elena Veleva, Amanda J Heslegrave, Henrik Zetterberg, Susie Schofield, Nicola T Fear, Christopher J Boos, Anthony M J Bull, Alexander Bennett, David J Sharp, ADVANCE Study
Poor long-term outcomes and abnormal neurodegeneration biomarkers after military traumatic brain injury: the ADVANCE study
European journal of neurology
Published
Pre-hospital transdermal glyceryl trinitrate for transient ischaemic attack: Data from the RIGHT-2 trial
Authors
Jason P Appleton, Mark Dixon, Lisa J Woodhouse, Craig S Anderson, Sandeep Ankolekar, Lesley Cala, Timothy J England, Peter J Godolphin, Kailash Krishnan, Grant Mair, Keith W Muir, John Potter, Chris I Price, Marc Randall, Thompson G Robinson, Christine Roffe, Peter M Rothwell, Else Charlotte Sandset, Jeffrey L Saver, A Niroshan Siriwardena, Joanna M Wardlaw, Nikola Sprigg, Philip M Bath, RIGHT‐2 Investigators
Pre-hospital transdermal glyceryl trinitrate for transient ischaemic attack: Data from the RIGHT-2 trial