Publications

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Jan 17, 2025 - Research

Brain changes in Huntington’s disease occur decades before diagnosis

Subtle changes in the brain happen approximately twenty years before a clinical motor diagnosis in people with Huntington’s disease, finds a new study led by...

Learn more Brain changes in Huntington’s disease occur decades before diagnosis

Jan 08, 2025 - Research

Genetic changes in brain cells link ageing and Alzheimer’s

Genetic differences that contribute to how long a person will live and their risk of Alzheimer’s disease have been identified in a new study led...

Learn more Genetic changes in brain cells link ageing and Alzheimer’s

Phospho-tau accumulation in MAPT knockout mice

Jan 08, 2025 - Research

Brain damage starts before tau protein clumps in frontotemporal dementia and Alzheimer’s

A new study led by Prof Karen Duff, Dr Naoto Watamura, and Dr Martha Foiani (UK DRI at UCL), with Prof Takaomi Saido (Riken Center...

Learn more Brain damage starts before tau protein clumps in frontotemporal dementia and Alzheimer’s

Cell

Published Jul 30, 2015

The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis.

Authors

Michael J Parsons, Marco Brancaccio, Siddharth Sethi, Elizabeth S Maywood, Rahul Satija, Jessica K Edwards, Aarti Jagannath, Yvonne Couch, Mattéa J Finelli, Nicola J Smyllie, Christopher Esapa, Rachel Butler, Alun R Barnard, Johanna E Chesham, Shoko Saito, Greg Joynson, Sara Wells, Russell G Foster, Peter L Oliver, Michelle M Simon, Ann-Marie Mallon, Michael H Hastings, Patrick M Nolan

The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis.

Neuron

Published Apr 22, 2015

Lengthening of the Stargazin Cytoplasmic Tail Increases Synaptic Transmission by Promoting Interaction to Deeper Domains of PSD-95.

Authors

Anne-Sophie Hafner, Andrew C Penn, Dolors Grillo-Bosch, Natacha Retailleau, Christel Poujol, Amandine Philippat, Françoise Coussen, Matthieu Sainlos, Patricio Opazo, Daniel Choquet

Lengthening of the Stargazin Cytoplasmic Tail Increases Synaptic Transmission by Promoting Interaction to Deeper Domains of PSD-95.

Nature

Published Feb 12, 2015

Grid cell symmetry is shaped by environmental geometry.

Authors

Julija Krupic, Marius Bauza, Stephen Burton, Caswell Barry, John O'Keefe

Grid cell symmetry is shaped by environmental geometry.

Nat Protoc

Published Jan 10, 2015

A high-throughput in vivo micronucleus assay for genome instability screening in mice.

Authors

Gabriel Balmus, Natasha A Karp, Bee Ling Ng, Stephen P Jackson, David J Adams, Rebecca E McIntyre

A high-throughput in vivo micronucleus assay for genome instability screening in mice.

BMC Biol

Published Jan 10, 2015

Retarded PDI diffusion and a reductive shift in poise of the calcium depleted endoplasmic reticulum.

Authors

Edward Avezov, Tasuku Konno, Alisa Zyryanova, Weiyue Chen, Romain Laine, Ana Crespillo-Casado, Eduardo Pinho Melo, Ryo Ushioda, Kazuhiro Nagata, Clemens F Kaminski, Heather P Harding, David Ron

Retarded PDI diffusion and a reductive shift in poise of the calcium depleted endoplasmic reticulum.

J Neurosci

Published Nov 12, 2014

Network-mediated encoding of circadian time: the suprachiasmatic nucleus (SCN) from genes to neurons to circuits, and back.

Authors

Marco Brancaccio, Ryosuke Enoki, Cristina N Mazuski, Jeff Jones, Jennifer A Evans, Abdelhalim Azzi

Network-mediated encoding of circadian time: the suprachiasmatic nucleus (SCN) from genes to neurons to circuits, and back.

Cell

Published Nov 06, 2014

Lessons from a failed γ-secretase Alzheimer trial.

Authors

Bart De Strooper

Lessons from a failed γ-secretase Alzheimer trial.

Science

Published Sep 05, 2014

C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins.

Authors

Sarah Mizielinska, Sebastian Grönke, Teresa Niccoli, Charlotte E Ridler, Emma L Clayton, Anny Devoy, Thomas Moens, Frances E Norona, Ione O C Woollacott, Julian Pietrzyk, Karen Cleverley, Andrew J Nicoll, Stuart Pickering-Brown, Jacqueline Dols, Melissa Cabecinha, Oliver Hendrich, Pietro Fratta, Elizabeth M C Fisher, Linda Partridge, Adrian M Isaacs

C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins.

Science

Published Aug 01, 2014

Interneurons. Fast-spiking, parvalbumin⁺ GABAergic interneurons: from cellular design to microcircuit function.

Authors

Hua Hu, Jian Gan, Peter Jonas

Interneurons. Fast-spiking, parvalbumin⁺ GABAergic interneurons: from cellular design to microcircuit function.

Neuron

Published May 21, 2014

The intersection of amyloid beta and tau at synapses in Alzheimer's disease.

Authors

Tara L Spires-Jones, Bradley T Hyman

The intersection of amyloid beta and tau at synapses in Alzheimer's disease.

Science

Published May 09, 2014

The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal.

Authors

Marcela Rosas, Luke C Davies, Peter J Giles, Chia-Te Liao, Bashar Kharfan, Timothy C Stone, Valerie B O'Donnell, Donald J Fraser, Simon A Jones, Philip R Taylor

The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal.

Neuron

Published Apr 16, 2014

Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes.

Authors

Soyon Hong, Beth L Ostaszewski, Ting Yang, Tiernan T O'Malley, Ming Jin, Katsuhiko Yanagisawa, Shaomin Li, Tim Bartels, Dennis J Selkoe

Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes.

Science

Published Apr 11, 2014

PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling.

Authors

Vanessa A Morais, Dominik Haddad, Katleen Craessaerts, Pieter-Jan De Bock, Jef Swerts, Sven Vilain, Liesbeth Aerts, Lut Overbergh, Anne Grünewald, Philip Seibler, Christine Klein, Kris Gevaert, Patrik Verstreken, Bart De Strooper

PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling.

Nature

Published Apr 03, 2014

Capillary pericytes regulate cerebral blood flow in health and disease.

Authors

Catherine N Hall, Clare Reynell, Bodil Gesslein, Nicola B Hamilton, Anusha Mishra, Brad A Sutherland, Fergus M O'Farrell, Alastair M Buchan, Martin Lauritzen, David Attwell

Capillary pericytes regulate cerebral blood flow in health and disease.

N Engl J Med

Published Mar 27, 2014

Thrombotic microangiopathy associated with interferon beta.

Authors

David Hunt, David Kavanagh, Iain Drummond, Belinda Weller, Chris Bellamy, James Overell, Stephen Evans, Andrew Jackson, Siddharthan Chandran

Thrombotic microangiopathy associated with interferon beta.

Philos Trans R Soc Lond B Biol Sci

Published Feb 05, 2014

How environment geometry affects grid cell symmetry and what we can learn from it.

Authors

Julija Krupic, Marius Bauza, Stephen Burton, Colin Lever, John O'Keefe

How environment geometry affects grid cell symmetry and what we can learn from it.

N Engl J Med

Published Jan 23, 2014

Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.

Authors

Stephen Salloway, Reisa Sperling, Nick C Fox, Kaj Blennow, William Klunk, Murray Raskind, Marwan Sabbagh, Lawrence S Honig, Anton P Porsteinsson, Steven Ferris, Marcel Reichert, Nzeera Ketter, Bijan Nejadnik, Volkmar Guenzler, Maja Miloslavsky, Daniel Wang, Yuan Lu, Julia Lull, Iulia Cristina Tudor, Enchi Liu, Michael Grundman, Eric Yuen, Ronald Black, H Robert Brashear,

Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.

Acta Neuropathol

Published Oct 30, 2013

C9orf72 frontotemporal lobar degeneration is characterised by frequent neuronal sense and antisense RNA foci.

Authors

Sarah Mizielinska, Tammaryn Lashley, Frances E Norona, Emma L Clayton, Charlotte E Ridler, Pietro Fratta, Adrian M Isaacs

C9orf72 frontotemporal lobar degeneration is characterised by frequent neuronal sense and antisense RNA foci.