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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Cell reports methods
Published
Human MAPT knockin mouse models of frontotemporal dementia for the neurodegenerative research community
Authors
Takahiro Morito, Mohan Qi, Naoko Kamano, Hiroki Sasaguri, Sumi Bez, Martha Foiani, Karen Duff, Seico Benner, Toshihiro Endo, Hiroshi Hama, Hiroshi Kurokawa, Atushi Miyawaki, Hiroshi Mizuma, Naruhiko Sahara, Masafumi Shimojo, Makoto Higuchi, Takaomi C Saido, Naoto Watamura
Human MAPT knockin mouse models of frontotemporal dementia for the neurodegenerative research community
Science advances
Published
Astrocytic RNA editing regulates the host immune response to alpha-synuclein
Authors
Karishma D'Sa, Minee L Choi, Aaron Z Wagen, Núria Setó-Salvia, Olga Kopach, James R Evans, Margarida Rodrigues, Patricia Lopez-Garcia, Joanne Lachica, Benjamin E Clarke, Jaijeet Singh, Ali Ghareeb, James Bayne, Melissa Grant-Peters, Sonia Garcia-Ruiz, Zhongbo Chen, Samuel Rodriques, Dilan Athauda, Emil K Gustavsson, Sarah A Gagliano Taliun, Christina Toomey, Regina H Reynolds, George Young, Stephanie Strohbuecker, Thomas Warner, Dmitri A Rusakov, Rickie Patani, Clare Bryant, David A Klenerman, Sonia Gandhi, Mina Ryten
Astrocytic RNA editing regulates the host immune response to alpha-synuclein
Neuroimaging clinics of North America
Published
Avenues in the Analysis of Enlarged Perivascular Spaces Quantified from Brain Magnetic Resonance Images Acquired at 1.5T and 3T Magnetic Field Strengths
Authors
Maria C Valdés Hernández, Roberto Duarte Coello, Alexandra Morozova, John McFadden, Charlotte Jardine, Gayle Barclay, Donna McIntyre, Francesca M Chappell, Michael Stringer, Michael J Thrippleton, Joanna M Wardlaw
Avenues in the Analysis of Enlarged Perivascular Spaces Quantified from Brain Magnetic Resonance Images Acquired at 1.5T and 3T Magnetic Field Strengths
Cell reports
Published
Differential neuronal vulnerability to C9orf72 repeat expansion driven by Xbp1-induced endoplasmic reticulum-associated degradation
Authors
Dunxin Shen, Alec Vincent, Evan Udine, Yazead Buhidma, Sharifah Anoar, Elli Tsintzas, Marie Maeland, Dongwei Xu, Mireia Carcolé, David Osumi-Sutherland, Benjamin Aleyakpo, Alexander Hull, Guillermo Martínez Corrales, Nathan Woodling, Rosa Rademakers, Adrian M Isaacs, Carlo Frigerio, Marka van Blitterswijk, Tammaryn Lashley, Teresa Niccoli
Differential neuronal vulnerability to C9orf72 repeat expansion driven by Xbp1-induced endoplasmic reticulum-associated degradation
Nature medicine
Published
Plasma phospho-tau217 for Alzheimer's disease diagnosis in primary and secondary care using a fully automated platform
Authors
Sebastian Palmqvist, Noëlle Warmenhoven, Federica Anastasi, Andrea Pilotto, Shorena Janelidze, Pontus Tideman, Erik Stomrud, Niklas Mattsson-Carlgren, Ruben Smith, Rik Ossenkoppele, Kübra Tan, Anna Dittrich, Ingmar Skoog, Henrik Zetterberg, Virginia Quaresima, Chiara Tolassi, Kina Höglund, Duilio Brugnoni, Albert Puig-Pijoan, Aida Fernández-Lebrero, José Contador, Alessandro Padovani, Mark Monane, Philip B Verghese, Joel B Braunstein, Silke Kern, Kaj Blennow, Nicholas J Ashton, Marc Suárez-Calvet, Oskar Hansson
Plasma phospho-tau217 for Alzheimer's disease diagnosis in primary and secondary care using a fully automated platform
Nature communications
Published
GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau
Authors
Diana Acosta Ingram, Emir Turkes, Tae Yeon Kim, Sheeny Vo, Nicholas Sweeney, Marie-Amandine Bonte, Ryan Rutherford, Dominic L Julian, Meixia Pan, Jacob Marsh, Andrea R Argouarch, Min Wu, Douglas W Scharre, Erica H Bell, Lawrence S Honig, Jean Paul Vonsattel, Geidy E Serrano, Thomas G Beach, Celeste M Karch, Aimee W Kao, Mark E Hester, Xianlin Han, Hongjun Fu
GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau
PLoS Biol
Published
Monocyte-secreted Wnt reduces the efficiency of central nervous system remyelination.
Authors
Bianca M Hill, Rebecca K Holloway, Lindsey H Forbes, Claire L Davies, Jonathan K Monteiro, Christina M Brown, Jamie Rose, Neva Fudge, Pamela J Plant, Ayisha Mahmood, Koroboshka Brand-Arzamendi, Sarah A Kent, Irene Molina-Gonzalez, Stefka Gyoneva, Richard M Ransohoff, Brian Wipke, Josef Priller, Raphael Schneider, Craig S Moore, Veronique E Miron
Monocyte-secreted Wnt reduces the efficiency of central nervous system remyelination.
Acta neuropathologica
Published
Seeding-competent early tau multimers are associated with cell type-specific transcriptional signatures
Authors
Rahel Feleke, Simona Jogaudaite, Elisavet Velentza-Almpani, Leung Yeung-Yeung, Daniel Clode, Jeong Hun Ko, Ben Shin, Steve Matthews, Maria Otero-Jimenez, Marcelina J Wojewska, Sandra Gray-Rodriguez, Sarah J Marzi, Maxwell P Spires-Jones, Tara L Spires-Jones, Michael R Johnson, Javier Alegre-Abarrategui
Seeding-competent early tau multimers are associated with cell type-specific transcriptional signatures
Nature communications
Published
A blood- and brain-based EWAS of smoking
Authors
Aleksandra D Chybowska, Elena Bernabeu, Paul Yousefi, Matthew Suderman, Robert F Hillary, Richard Clark, Louise MacGillivray, Lee Murphy, Sarah E Harris, Janie Corley, Archie Campbell, Tara L Spires-Jones, Daniel L McCartney, Simon R Cox, Jackie F Price, Kathryn L Evans, Riccardo E Marioni
A blood- and brain-based EWAS of smoking