Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

Cytokines released by T cells after encountering cancer cells

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system
BMJ Open
Published
Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART): a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlled trial of repurposed drugs in motor neuron disease.
Authors
Charis Wong, Rachel S Dakin, Jill Williamson, Judith Newton, Michelle Steven, Shuna Colville, Maria Stavrou, Jenna M Gregory, Elizabeth Elliott, Arpan R Mehta, Jeremy Chataway, Robert J Swingler, Richard Anthony Parker, Christopher J Weir, Nigel Stallard, Mahesh K B Parmar, Malcolm R Macleod, Suvankar Pal, Siddharthan Chandran
Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART): a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlled trial of repurposed drugs in motor neuron disease.
Science
Published
A specific circuit in the midbrain detects stress and induces restorative sleep.
Authors
Xiao Yu, Guangchao Zhao, Dan Wang, Sa Wang, Rui Li, Ao Li, Huan Wang, Mathieu Nollet, You Young Chun, Tianyuan Zhao, Raquel Yustos, Huiming Li, Jianshuai Zhao, Jiannan Li, Min Cai, Alexei L Vyssotski, Yulong Li, Hailong Dong, Nicholas P Franks, William Wisden
A specific circuit in the midbrain detects stress and induces restorative sleep.
Front Comput Neurosci
Published
Recent Trends in Non-invasive Neural Recording Based Brain-to-Brain Synchrony Analysis on Multidisciplinary Human Interactions for Understanding Brain Dynamics: A Systematic Review.
Authors
Tahnia Nazneen, Iffath Binta Islam, Md Sakibur Rahman Sajal, Wasifa Jamal, M Ashraful Amin, Ravi Vaidyanathan, Tom Chau, Khondaker A Mamun
Recent Trends in Non-invasive Neural Recording Based Brain-to-Brain Synchrony Analysis on Multidisciplinary Human Interactions for Understanding Brain Dynamics: A Systematic Review.
Cell Stem Cell
Published
Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neurons.
Authors
Lucia S Capano, Chihiro Sato, Elena Ficulle, Anan Yu, Kanta Horie, Ji-Sun Kwon, Kyle F Burbach, Nicolas R Barthélemy, Susan G Fox, Celeste M Karch, Randall J Bateman, Henry Houlden, Richard I Morimoto, David M Holtzman, Karen E Duff, Andrew S Yoo
Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neurons.
Acta Neuropathol
Published
Loss of the heterogeneous expression of flippase ATP11B leads to cerebral small vessel disease in a normotensive rat model.
Authors
Sophie Quick, Tessa V Procter, Jonathan Moss, Luise Seeker, Marc Walton, Angus Lawson, Serena Baker, Anna Beletski, Daniela Jaime Garcia, Mehreen Mohammad, William Mungall, Ami Onishi, Zuzanna Tobola, Michael Stringer, Maurits A Jansen, Antoine Vallatos, Ylenia Giarratano, Miguel O Bernabeu, Joanna M Wardlaw, Anna Williams
Loss of the heterogeneous expression of flippase ATP11B leads to cerebral small vessel disease in a normotensive rat model.
Cell Rep
Published
Cholesterol determines the cytosolic entry and seeded aggregation of tau.
Authors
Benjamin J Tuck, Lauren V C Miller, Taxiarchis Katsinelos, Annabel E Smith, Emma L Wilson, Sophie Keeling, Shi Cheng, Marina J Vaysburd, Claire Knox, Lucy Tredgett, Emmanouil Metzakopian, Leo C James, William A McEwan
Cholesterol determines the cytosolic entry and seeded aggregation of tau.
Exp Neurol
Published
DyNeuMo Mk-1: Design and pilot validation of an investigational motion-adaptive neurostimulator with integrated chronotherapy.
Authors
Mayela Zamora, Robert Toth, Francesca Morgante, Jon Ottaway, Tom Gillbe, Sean Martin, Guy Lamb, Tara Noone, Moaad Benjaber, Zachary Nairac, Devang Sehgal, Timothy G Constandinou, Jeffrey Herron, Tipu Z Aziz, Ivor Gillbe, Alexander L Green, Erlick A C Pereira, Timothy Denison
DyNeuMo Mk-1: Design and pilot validation of an investigational motion-adaptive neurostimulator with integrated chronotherapy.
Biosens Bioelectron
Published
Multiplexed immunosensors for point-of-care diagnostic applications.
Authors
Bruno Gil Rosa, Oluwatomi E Akingbade, Xiaotong Guo, Laura Gonzalez-Macia, Michael A Crone, Loren P Cameron, Paul Freemont, Kwang-Leong Choy, Firat Güder, Eric Yeatman, David J Sharp, Bing Li
Multiplexed immunosensors for point-of-care diagnostic applications.