Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

Cytokines released by T cells after encountering cancer cells

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system
BMJ Open
Published

Multicohort cross-sectional study of cognitive and behavioural digital biomarkers in neurodegeneration: the Living Lab Study protocol.

Authors
Mark Crook-Rumsey, Sarah J C Daniels, Subati Abulikemu, Helen Lai, Adrien Rapeaux, Charalambos Hadjipanayi, Eyal Soreq, Lucia M Li, James Bashford, Julian Jeyasingh-Jacob, Dragos C Gruia, Damion Lambert, Rimona Weil, Adam Hampshire, David J Sharp, Shlomi Haar
Multicohort cross-sectional study of cognitive and behavioural digital biomarkers in neurodegeneration: the Living Lab Study protocol.
Brain
Published

Microglial activation in the frontal cortex predicts cognitive decline in frontotemporal dementia.

Authors
Maura Malpetti, Thomas E Cope, Duncan Street, P Simon Jones, Frank H Hezemans, Elijah Mak, Kamen A Tsvetanov, Timothy Rittman, W Richard Bevan-Jones, Karalyn Patterson, Luca Passamonti, Tim D Fryer, Young T Hong, Franklin I Aigbirhio, John T O'Brien, James B Rowe
Microglial activation in the frontal cortex predicts cognitive decline in frontotemporal dementia.
Brain
Published

Microglial activation in the frontal cortex predicts cognitive decline in frontotemporal dementia.

Authors
Maura Malpetti, Thomas E Cope, Duncan Street, P Simon Jones, Frank H Hezemans, Elijah Mak, Kamen A Tsvetanov, Timothy Rittman, W Richard Bevan-Jones, Karalyn Patterson, Luca Passamonti, Tim D Fryer, Young T Hong, Franklin I Aigbirhio, John T O'Brien, James B Rowe
Microglial activation in the frontal cortex predicts cognitive decline in frontotemporal dementia.
Lancet Neurol
Published

Progression of cerebral amyloid angiopathy: a pathophysiological framework.

Authors
Emma A Koemans, Jasmeer P Chhatwal, Susanne J van Veluw, Ellis S van Etten, Matthias J P van Osch, Marianne A A van Walderveen, Hamid R Sohrabi, Mariel G Kozberg, Zahra Shirzadi, Gisela M Terwindt, Mark A van Buchem, Eric E Smith, David J Werring, Ralph N Martins, Marieke J H Wermer, Steven M Greenberg
Progression of cerebral amyloid angiopathy: a pathophysiological framework.
Cell Rep
Published

Super-resolution imaging unveils the self-replication of tau aggregates upon seeding.

Authors
Eleni Dimou, Taxiarchis Katsinelos, Georg Meisl, Benjamin J Tuck, Sophie Keeling, Annabel E Smith, Eric Hidari, Jeff Y L Lam, Melanie Burke, Sofia Lövestam, Rohan T Ranasinghe, William A McEwan, David Klenerman
Super-resolution imaging unveils the self-replication of tau aggregates upon seeding.
Cell Rep
Published

Super-resolution imaging unveils the self-replication of tau aggregates upon seeding.

Authors
Eleni Dimou, Taxiarchis Katsinelos, Georg Meisl, Benjamin J Tuck, Sophie Keeling, Annabel E Smith, Eric Hidari, Jeff Y L Lam, Melanie Burke, Sofia Lövestam, Rohan T Ranasinghe, William A McEwan, David Klenerman
Super-resolution imaging unveils the self-replication of tau aggregates upon seeding.
iScience
Published

Calcium dysregulation combined with mitochondrial failure and electrophysiological maturity converge in Parkinson's iPSC-dopamine neurons.

Authors
Dayne A Beccano-Kelly, Marta Cherubini, Yassine Mousba, Kaitlyn M L Cramb, Stefania Giussani, Maria Claudia Caiazza, Pavandeep Rai, Siv Vingill, Nora Bengoa-Vergniory, Bryan Ng, Gabriele Corda, Abhirup Banerjee, Jane Vowles, Sally Cowley, Richard Wade-Martins
Calcium dysregulation combined with mitochondrial failure and electrophysiological maturity converge in Parkinson's iPSC-dopamine neurons.
Neuron
Published

Synaptic oligomeric tau in Alzheimer’s disease - A potential culprit in the spread of tau pathology through the brain.

Authors
Martí Colom-Cadena, Caitlin Davies , Sònia Sirisi, Ji-Eun Lee, Elizabeth M. Simzer, Makis Tzioras, Marta Querol-Vilaseca, Érika Sánchez-Aced, Ya Yin Chang, Kristjan Holt, Robert I. McGeachan, Jamie Rose, Jane Tulloch, Lewis Wilkins, Colin Smith, Teodora Andrian, Olivia Belbin, Sílvia Pujals, Mathew H. Horrocks, Alberto Lleó, Tara L. Spires-Jones
Synaptic oligomeric tau in Alzheimer’s disease - A potential culprit in the spread of tau pathology through the brain.
Neuron
Published

Synaptic oligomeric tau in Alzheimer's disease - A potential culprit in the spread of tau pathology through the brain.

Authors
Martí Colom-Cadena, Caitlin Davies, Sònia Sirisi, Ji-Eun Lee, Elizabeth M Simzer, Makis Tzioras, Marta Querol-Vilaseca, Érika Sánchez-Aced, Ya Yin Chang, Kristjan Holt, Robert I McGeachan, Jamie Rose, Jane Tulloch, Lewis Wilkins, Colin Smith, Teodora Andrian, Olivia Belbin, Sílvia Pujals, Mathew H Horrocks, Alberto Lleó, Tara L Spires-Jones
Synaptic oligomeric tau in Alzheimer's disease - A potential culprit in the spread of tau pathology through the brain.
EMBO J
Published

HNRNPH1 regulates the neuroprotective cold-shock protein RBM3 expression through poison exon exclusion.

Authors
Julie Qiaojin Lin, Deepak Khuperkar, Sofia Pavlou, Stanislaw Makarchuk, Nikolaos Patikas, Flora Cy Lee, Julia M Zbiegly, Jianning Kang, Sarah F Field, David Md Bailey, Joshua L Freeman, Jernej Ule, Emmanouil Metzakopian, Marc-David Ruepp, Giovanna R Mallucci
HNRNPH1 regulates the neuroprotective cold-shock protein RBM3 expression through poison exon exclusion.
EMBO J
Published

HNRNPH1 regulates the neuroprotective cold-shock protein RBM3 expression through poison exon exclusion.

Authors
Julie Qiaojin Lin, Deepak Khuperkar, Sofia Pavlou, Stanislaw Makarchuk, Nikolaos Patikas, Flora Cy Lee, Julia M Zbiegly, Jianning Kang, Sarah F Field, David Md Bailey, Joshua L Freeman, Jernej Ule, Emmanouil Metzakopian, Marc-David Ruepp, Giovanna R Mallucci
HNRNPH1 regulates the neuroprotective cold-shock protein RBM3 expression through poison exon exclusion.