Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

Cytokines released by T cells after encountering cancer cells

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system
Lancet Neurol
Published

A biological classification of Huntington's disease: the Integrated Staging System.

Authors
Sarah J Tabrizi, Scott Schobel, Emily C Gantman, Alexandra Mansbach, Beth Borowsky, Pavlina Konstantinova, Tiago A Mestre, Jennifer Panagoulias, Christopher A Ross, Maurice Zauderer, Ariana P Mullin, Klaus Romero, Sudhir Sivakumaran, Emily C Turner, Jeffrey D Long, Cristina Sampaio,
A biological classification of Huntington's disease: the Integrated Staging System.
Mol Neurodegener
Published

17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson's disease are associated with LRRC37A/2 expression in astrocytes.

Authors
Kathryn R Bowles, Derian A Pugh, Yiyuan Liu, Tulsi Patel, Alan E Renton, Sara Bandres-Ciga, Ziv Gan-Or, Peter Heutink, Ari Siitonen, Sarah Bertelsen, Jonathan D Cherry, Celeste M Karch, Steven J Frucht, Brian H Kopell, Inga Peter, Y J Park, , Alexander Charney, Towfique Raj, John F Crary, A M Goate
17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson's disease are associated with LRRC37A/2 expression in astrocytes.
Nat Neurosci
Published

Identification of early neurodegenerative pathways in progressive multiple sclerosis.

Authors
Max Kaufmann, Anna-Lena Schaupp, Rosa Sun, Fabian Coscia, Calliope A Dendrou, Adrian Cortes, Gurman Kaur, Hayley G Evans, Annelie Mollbrink, José Fernández Navarro, Jana K Sonner, Christina Mayer, Gabriele C DeLuca, Joakim Lundeberg, Paul M Matthews, Kathrine E Attfield, Manuel A Friese, Matthias Mann, Lars Fugger
Identification of early neurodegenerative pathways in progressive multiple sclerosis.
Neurology
Published

Associations of β-Amyloid and Vascular Burden With Rates of Neurodegeneration in Cognitively Normal Members of the 1946 British Birth Cohort.

Authors
Sarah E Keuss, William Coath, Jennifer M Nicholas, Teresa Poole, Josephine Barnes, David M Cash, Christopher A Lane, Thomas D Parker, Ashvini Keshavan, Sarah M Buchanan, Aaron Z Wagen, Mathew Storey, Matthew Harris, Ian B Malone, Carole H Sudre, Kirsty Lu, Sarah-Naomi James, Rebecca Street, David L Thomas, John C Dickson, Heidi Murray-Smith, Andrew Wong, Tamar Freiberger, Sebastian Crutch, Marcus Richards, Nick C Fox, Jonathan M Schott
Associations of β-Amyloid and Vascular Burden With Rates of Neurodegeneration in Cognitively Normal Members of the 1946 British Birth Cohort.
BMJ Open
Published

Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART): a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlled trial of repurposed drugs in motor neuron disease.

Authors
Charis Wong, Rachel S Dakin, Jill Williamson, Judith Newton, Michelle Steven, Shuna Colville, Maria Stavrou, Jenna M Gregory, Elizabeth Elliott, Arpan R Mehta, Jeremy Chataway, Robert J Swingler, Richard Anthony Parker, Christopher J Weir, Nigel Stallard, Mahesh K B Parmar, Malcolm R Macleod, Suvankar Pal, Siddharthan Chandran
Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART): a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlled trial of repurposed drugs in motor neuron disease.
BMJ Open
Published

Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART): a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlled trial of repurposed drugs in motor neuron disease.

Authors
Charis Wong, Rachel S Dakin, Jill Williamson, Judith Newton, Michelle Steven, Shuna Colville, Maria Stavrou, Jenna M Gregory, Elizabeth Elliott, Arpan R Mehta, Jeremy Chataway, Robert J Swingler, Richard Anthony Parker, Christopher J Weir, Nigel Stallard, Mahesh K B Parmar, Malcolm R Macleod, Suvankar Pal, Siddharthan Chandran
Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART): a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlled trial of repurposed drugs in motor neuron disease.