Publications

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Jan 28, 2026 - Research

Targeting the gut's immune system could tackle early stages of Parkinson's

New research, led by Dr Soyon Hong and Dr Tim Bartels at the UK DRI at UCL, has revealed how Parkinson’s spreads from the gut...

Learn more Targeting the gut's immune system could tackle early stages of Parkinson's

Cytokines released by T cells after encountering cancer cells

Jan 23, 2026

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system

Jan 14, 2026 - Research

Brain shrinkage and inflammation predict disease progression in progressive supranuclear palsy

New research led by Dr Maura Malpetti and Noah Shapiro (UK DRI at Cambridge) reveals signs of brain shrinkage, inflammation and blood markers for nerve...

Learn more Brain shrinkage and inflammation predict disease progression in progressive supranuclear palsy

Science

Published Jul 05, 2019

Targeting microglia in brain disorders.

Authors

Josef Priller, Marco Prinz

Targeting microglia in brain disorders.

PLoS Pathog

Published Jun 26, 2019

The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors.

Authors

Aiysha Thompson, Luke C Davies, Chia-Te Liao, Diogo M da Fonseca, James S Griffiths, Robert Andrews, Adam V Jones, Mathew Clement, Gordon D Brown, Ian R Humphreys, Philip R Taylor, Selinda J Orr

The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors.

J Biol Chem

Published Jun 21, 2019

E46K-like α-synuclein mutants increase lipid interactions and disrupt membrane selectivity.

Authors

Matteo Rovere, Alex E Powers, Haiyang Jiang, Julia C Pitino, Luis Fonseca-Ornelas, Dushyant S Patel, Alessandro Achille, Ralf Langen, Jobin Varkey, Tim Bartels

E46K-like α-synuclein mutants increase lipid interactions and disrupt membrane selectivity.

Nat Rev Neurol

Published Jun 20, 2019

SILK studies - capturing the turnover of proteins linked to neurodegenerative diseases.

Authors

Ross W Paterson, Audrey Gabelle, Brendan P Lucey, Nicolas R Barthélemy, Claire A Leckey, Christophe Hirtz, Sylvain Lehmann, Chihiro Sato, Bruce W Patterson, Tim West, Kevin Yarasheski, Jonathan D Rohrer, Norelle C Wildburger, Jonathan M Schott, Celeste M Karch, Selina Wray, Timothy M Miller, Donald L Elbert, Henrik Zetterberg, Nick C Fox, Randall J Bateman

SILK studies - capturing the turnover of proteins linked to neurodegenerative diseases.

Brain

Published Jun 19, 2019

MSH3 modifies somatic instability and disease severity in Huntington's and myotonic dystrophy type 1.

Authors

Michael Flower, Vilija Lomeikaite, Marc Ciosi, Sarah Cumming, Fernando Morales, Kitty Lo, Davina Hensman Moss, Lesley Jones, Peter Holmans, , , Darren G Monckton, Sarah J Tabrizi

MSH3 modifies somatic instability and disease severity in Huntington's and myotonic dystrophy type 1.

N Engl J Med

Published Jun 13, 2019

Targeting Huntingtin Expression in Patients with Huntington's Disease.

Authors

Sarah J Tabrizi, Blair R Leavitt, G Bernhard Landwehrmeyer, Edward J Wild, Carsten Saft, Roger A Barker, Nick F Blair, David Craufurd, Josef Priller, Hugh Rickards, Anne Rosser, Holly B Kordasiewicz, Christian Czech, Eric E Swayze, Daniel A Norris, Tiffany Baumann, Irene Gerlach, Scott A Schobel, Erika Paz, Anne V Smith, C Frank Bennett, Roger M Lane,

Targeting Huntingtin Expression in Patients with Huntington's Disease.

Nat Neurosci

Published Jun 10, 2019

Central nervous system regeneration is driven by microglia necroptosis and repopulation.

Authors

Amy F Lloyd, Claire L Davies, Rebecca K Holloway, Yasmine Labrak, Graeme Ireland, Dario Carradori, Alessandra Dillenburg, Eva Borger, Daniel Soong, Jill C Richardson, Tanja Kuhlmann, Anna Williams, Jeffrey W Pollard, Anne des Rieux, Josef Priller, Veronique E Miron

Central nervous system regeneration is driven by microglia necroptosis and repopulation.

Sci Transl Med

Published May 29, 2019

Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition.

Authors

Roger A Habets, Charles E de Bock, Lutgarde Serneels, Inge Lodewijckx, Delphine Verbeke, David Nittner, Rajeshwar Narlawar, Sofie Demeyer, James Dooley, Adrian Liston, Tom Taghon, Jan Cools, Bart de Strooper

Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition.

Immunology

Published May 23, 2019

Development and characterization of novel anti-C5 monoclonal antibodies capable of inhibiting complement in multiple species.

Authors

Wioleta M Zelek, Philip R Taylor, B Paul Morgan

Development and characterization of novel anti-C5 monoclonal antibodies capable of inhibiting complement in multiple species.

J Neuroinflammation

Published May 18, 2019

Lipopolysaccharide-induced neuroinflammation induces presynaptic disruption through a direct action on brain tissue involving microglia-derived interleukin 1 beta.

Authors

Olivia Sheppard, Michael P Coleman, Claire S Durrant

Lipopolysaccharide-induced neuroinflammation induces presynaptic disruption through a direct action on brain tissue involving microglia-derived interleukin 1 beta.

Front Immunol

Published May 17, 2019

Myeloid Cell and Transcriptome Signatures Associated With Inflammation Resolution in a Model of Self-Limiting Acute Brain Inflammation.

Authors

Claire L Davies, Anirudh Patir, Barry W McColl

Myeloid Cell and Transcriptome Signatures Associated With Inflammation Resolution in a Model of Self-Limiting Acute Brain Inflammation.

Amyotroph Lateral Scler Frontotemporal Degener

Published May 17, 2019

Clinical audit research and evaluation of motor neuron disease (CARE-MND): a national electronic platform for prospective, longitudinal monitoring of MND in Scotland.

Authors

Danielle Leighton, Judith Newton, Shuna Colville, Andrew Bethell, Gillian Craig, Laura Cunningham, Moira Flett, Dianne Fraser, Janice Hatrick, Helen Lennox, Laura Marshall, Dympna McAleer, Alison McEleney, Kitty Millar, Ann Silver, Laura Stephenson, Susan Stewart, Dorothy Storey, Gill Stott, Carol Thornton, Carolyn Webber, Harry Gordon, Giulia Melchiorre, Laura Sherlock, Emily Beswick, David Buchanan, Sharon Abrahams, Anthony Bateman, Jenny Preston, Callum Duncan, Richard Davenport, George Gorrie, Ian Morrison, Robert Swingler, Siddharthan Chandran, Suvankar Pal

Clinical audit research and evaluation of motor neuron disease (CARE-MND): a national electronic platform for prospective, longitudinal monitoring of MND in Scotland.

PLoS One

Published May 03, 2019

Health management and pattern analysis of daily living activities of people with dementia using in-home sensors and machine learning techniques.

Authors

Shirin Enshaeifar, Ahmed Zoha, Andreas Markides, Severin Skillman, Sahr Thomas Acton, Tarek Elsaleh, Masoud Hassanpour, Alireza Ahrabian, Mark Kenny, Stuart Klein, Helen Rostill, Ramin Nilforooshan, Payam Barnaghi

Health management and pattern analysis of daily living activities of people with dementia using in-home sensors and machine learning techniques.

Mol Psychiatry

Published Apr 12, 2019

Familial Alzheimer's disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta.

Authors

Charles Arber, Jamie Toombs, Christopher Lovejoy, Natalie S Ryan, Ross W Paterson, Nanet Willumsen, Eleni Gkanatsiou, Erik Portelius, Kaj Blennow, Amanda Heslegrave, Jonathan M Schott, John Hardy, Tammaryn Lashley, Nick C Fox, Henrik Zetterberg, Selina Wray

Familial Alzheimer's disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta.

Neuron

Published Mar 06, 2019

Huntingtin Lowering Strategies for Disease Modification in Huntington's Disease.

Authors

Sarah J Tabrizi, Rhia Ghosh, Blair R Leavitt

Huntingtin Lowering Strategies for Disease Modification in Huntington's Disease.

Hum Mol Genet

Published Feb 15, 2019

FAN1 modifies Huntington's disease progression by stabilizing the expanded HTT CAG repeat.

Authors

Robert Goold, Michael Flower, Davina Hensman Moss, Chris Medway, Alison Wood-Kaczmar, Ralph Andre, Pamela Farshim, Gill P Bates, Peter Holmans, Lesley Jones, Sarah J Tabrizi

FAN1 modifies Huntington's disease progression by stabilizing the expanded HTT CAG repeat.

Nature

Published Feb 13, 2019

Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution.

Authors

Takahiro Masuda, Roman Sankowski, Ori Staszewski, Chotima Böttcher, Lukas Amann, Sagar, Christian Scheiwe, Stefan Nessler, Patrik Kunz, Geert van Loo, Volker Arnd Coenen, Peter Christoph Reinacher, Anna Michel, Ulrich Sure, Ralf Gold, Dominic Grün, Josef Priller, Christine Stadelmann, Marco Prinz

Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution.

Glia

Published Feb 13, 2019

A core transcriptional signature of human microglia: Derivation and utility in describing region-dependent alterations associated with Alzheimer's disease.

Authors

Anirudh Patir, Barbara Shih, Barry W McColl, Tom C Freeman

A core transcriptional signature of human microglia: Derivation and utility in describing region-dependent alterations associated with Alzheimer's disease.