Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

Cytokines released by T cells after encountering cancer cells

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system
Alzheimer's research & therapy
Published
Hormone therapy is associated with lower Alzheimer's disease tau biomarkers in post-menopausal females -evidence from two independent cohorts
Authors
Yi-Ting Wang, Joseph Therriault, Cécile Tissot, Stijn Servaes, Nesrine Rahmouni, Arthur Cassa Macedo, Jaime Fernandez-Arias, Sulantha S Mathotaarachchi, Jenna Stevenson, Firoza Z Lussier, Andréa L Benedet, Tharick A Pascoal, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, Serge Gauthier, Pedro Rosa-Neto
Hormone therapy is associated with lower Alzheimer's disease tau biomarkers in post-menopausal females -evidence from two independent cohorts
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
CSF glial biomarkers are associated with cognition in individuals at risk of Alzheimer's disease
Authors
Noëlle Warmenhoven, Gonzalo Sánchez-Benavides, Armand González-Escalante, Marta Milà-Alomà, Mahnaz Shekari, David López-Martos, Paula Ortiz-Romero, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Carolina Minguillón, Juan Domingo Gispert, Natalia Vilor-Tejedor, Eider Arenaza-Urquijo, Eleni Palpatzis, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, Marc Suárez-Calvet, Oriol Grau-Rivera, ALFA Study
CSF glial biomarkers are associated with cognition in individuals at risk of Alzheimer's disease
Epilepsia
Published
Elevated plasma neurofilament light and glial fibrillary acidic protein in epilepsy versus nonepileptic seizures and nonepileptic disorders
Authors
Hannah Dobson, Said Al Maawali, Charles Malpas, Alexander F Santillo, Matthew Kang, Marian Todaro, Rosie Watson, Nawaf Yassi, Kaj Blennow, Henrik Zetterberg, Emma Foster, Andrew Neal, Dennis Velakoulis, Terence John O'Brien, Dhamidhu Eratne, Patrick Kwan
Elevated plasma neurofilament light and glial fibrillary acidic protein in epilepsy versus nonepileptic seizures and nonepileptic disorders
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
KLOTHO KL-VS heterozygosity is associated with diminished age-related neuroinflammation, neurodegeneration, and synaptic dysfunction in older cognitively unimpaired adults
Authors
Ira Frahmand Driscoll, Sarah Lose, Yue Ma, Barbara B Bendlin, Catherine Gallagher, Sterling C Johnson, Sanjay Asthana, Bruce Hermann, Mark A Sager, Kaj Blennow, Henrik Zetterberg, Cynthia Carlsson, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Dena Dubal, Ozioma C Okonkwo
KLOTHO KL-VS heterozygosity is associated with diminished age-related neuroinflammation, neurodegeneration, and synaptic dysfunction in older cognitively unimpaired adults
J Neurochem
Published
Mass spectrometry imaging highlights dynamic patterns of lipid co-expression with Aβ plaques in mouse and human brains.
Authors
Helen Xuexia Huang, Paolo Inglese, Jiabin Tang, Riad Yagoubi, Gonçalo D S Correia, Verena M Horneffer-van der Sluis, Stephane Camuzeaux, Vincen Wu, Maksym V Kopanitsa, Nanet Willumsen, Johanna S Jackson, Anna M Barron, Takashi Saito, Takaomi C Saido, Steve Gentlemen, Zoltan Takats, Paul M Matthews
Mass spectrometry imaging highlights dynamic patterns of lipid co-expression with Aβ plaques in mouse and human brains.
Molecular neurodegeneration
Published
Tau protein profiling in tauopathies: a human brain study
Authors
Juan Lantero-Rodriguez, Elena Camporesi, Laia Montoliu-Gaya, Johan Gobom, Diana Piotrowska, Maria Olsson, Irena Matečko Burmann, Bruno Becker, Ann Brinkmalm, Björn M Burmann, Michael Perkinton, Nicholas J Ashton, Nick C Fox, Tammaryn Lashley, Henrik Zetterberg, Kaj Blennow, Gunnar Brinkmalm
Tau protein profiling in tauopathies: a human brain study
Acta neuropathologica
Published
Amyloid-β peptide signature associated with cerebral amyloid angiopathy in familial Alzheimer's disease with APPdup and Down syndrome
Authors
Amal Kasri, Elena Camporesi, Eleni Gkanatsiou, Susana Boluda, Gunnar Brinkmalm, Lev Stimmer, Junyue Ge, Jörg Hanrieder, Nicolas Villain, Charles Duyckaerts, Yannick Vermeiren, Sarah E Pape, Gaël Nicolas, Annie Laquerrière, Peter Paul De Deyn, David Wallon, Kaj Blennow, Andre Strydom, Henrik Zetterberg, Marie-Claude Potier
Amyloid-β peptide signature associated with cerebral amyloid angiopathy in familial Alzheimer's disease with APPdup and Down syndrome
Fluids and barriers of the CNS
Published
Involvement of the choroid plexus in Alzheimer's disease pathophysiology: findings from mouse and human proteomic studies
Authors
Aurore Delvenne, Charysse Vandendriessche, Johan Gobom, Marlies Burgelman, Pieter Dujardin, Clint De Nolf, Betty M Tijms, Charlotte E Teunissen, Suzanne E Schindler, Frans Verhey, Inez Ramakers, Pablo Martinez-Lage, Mikel Tainta, Rik Vandenberghe, Jolien Schaeverbeke, Sebastiaan Engelborghs, Ellen De Roeck, Julius Popp, Gwendoline Peyratout, Magda Tsolaki, Yvonne Freund-Levi, Simon Lovestone, Johannes Streffer, Lars Bertram, Kaj Blennow, Henrik Zetterberg, Pieter Jelle Visser, Roosmarijn E Vandenbroucke, Stephanie J B Vos
Involvement of the choroid plexus in Alzheimer's disease pathophysiology: findings from mouse and human proteomic studies
Research square
Published
Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease
Authors
Stephanie Debette, Ilana Caro, Daniel Western, Shinichi Namba, Na Sun, Shuji Kawaguchi, Yunye He, Masashi Fujita, Gennady Roshchupkin, Tim D'Aoust, Marie-Gabrielle Duperron, Murali Sargurupremraj, Ami Tsuchida, Masaru Koido, Marziehsadat Ahmadi, Chengran Yang, Jigyasha Timsina, Laura Ibanez, Koichi Matsuda, Yutaka Suzuki, Yoshiya Oda, Akinori Kanai, Pouria Jandaghi, Hans Markus Munter, Dan Auld, Iana Astafeva, Raquel Puerta, Jerome Rotter, Bruce Psaty, Joshua Bis, Will Longstreth, Thierry Couffinhal, Pablo Garcia-Gonzalez, Vanesa Pytel, Marta Marquié, Amanda Cano, Mercè Boada, Marc Joliot, Mark Lathrop, Quentin Le Grand, Lenore Launer, Joanna Wardlaw, Myriam Heiman, Agustin Ruiz, Paul Matthews, Sudha Seshadri, Myriam Fornage, Hieab Adams, Aniket Mishra, David-Alexandre Trégouët, Yukinori Okada, Manolis Kellis, Philip De Jager, Christophe Tzourio, Yoichiro Kamatani, Fumihiko Matsuda, Carlos Cruchaga
Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease
bioRxiv : the preprint server for biology
Published
The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases uncovers cholesterol as a regulator of astrocyte reactivity impaired by ApoE4
Authors
Femke M Feringa, Sascha J Koppes-den Hertog, Lian Wang, Rico J E Derks, Iris Kruijff, Lena Erlebach, Jorin Heijneman, Ricardo Miramontes, Nadine Pömpner, Niek Blomberg, Damien Olivier-Jimenez, Lill Eva Johansen, Alexander J Cammack, Ashling Giblin, Christina E Toomey, Indigo V L Rose, Hebao Yuan, Michael Ward, Adrian M Isaacs, Martin Kampmann, Deborah Kronenberg-Versteeg, Tammaryn Lashley, Leslie M Thompson, Alessandro Ori, Yassene Mohammed, Martin Giera, Rik van der Kant
The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases uncovers cholesterol as a regulator of astrocyte reactivity impaired by ApoE4
J Neurol Neurosurg Psychiatry
Published
Rates of cortical thinning in Alzheimer's disease signature regions associate with vascular burden but not with β-amyloid status in cognitively normal adults at age 70.
Authors
Sarah E Keuss, William Coath, David M Cash, Josephine Barnes, Jennifer M Nicholas, Christopher A Lane, Thomas D Parker, Ashvini Keshavan, Sarah M Buchanan, Aaron Z Wagen, Mathew Storey, Matthew Harris, Kirsty Lu, Sarah-Naomi James, Rebecca Street, Ian B Malone, Carole H Sudre, David L Thomas, John C Dickson, Frederik Barkhof, Heidi Murray-Smith, Andrew Wong, Marcus Richards, Nick C Fox, Jonathan M Schott
Rates of cortical thinning in Alzheimer's disease signature regions associate with vascular burden but not with β-amyloid status in cognitively normal adults at age 70.
Journal of Alzheimer's disease : JAD
Published
Cognition Mediates the Association Between Cerebrospinal Fluid Biomarkers of Amyloid and P-Tau and Neuropsychiatric Symptoms
Authors
Brandon Frank, Michael Walsh, Landon Hurley, Jenna Groh, Kaj Blennow, Henrik Zetterberg, Yorghos Tripodis, Andrew E Budson, Maureen K O'Connor, Brett Martin, Jason Weller, Ann McKee, Wendy Qiu, Thor D Stein, Robert A Stern, Jesse Mez, Rachel Henson, Justin Long, Andrew J Aschenbrenner, Ganesh M Babulal, John C Morris, Suzanne Schindler, Michael L Alosco
Cognition Mediates the Association Between Cerebrospinal Fluid Biomarkers of Amyloid and P-Tau and Neuropsychiatric Symptoms
Journal of virus eradication
Published
Impact of interrupting antiretroviral therapy started during primary HIV-1 infection on plasma neurofilament light chain protein, a marker of neuronal injury: The SPARTAC trial
Authors
Jasmini Alagaratnam, Wolfgang Stöhr, Elizabeth Hamlyn, Kholoud Porter, Jamie Toombs, Amanda Heslegrave, Henrik Zetterberg, Magnus Gisslén, Jonathan Underwood, Mauro Schechter, Pontiano Kaleebu, Giuseppe Tambussi, Sabine Kinloch, Jose M Miro, Anthony D Kelleher, Abdel Babiker, John Frater, Alan Winston, Sarah Fidler, SPARTAC Trial Investigators
Impact of interrupting antiretroviral therapy started during primary HIV-1 infection on plasma neurofilament light chain protein, a marker of neuronal injury: The SPARTAC trial
Am J Hum Genet
Published
Genome-wide analyses reveal a potential role for the MAPT, MOBP, and APOE loci in sporadic frontotemporal dementia.
Authors
Claudia Manzoni, Demis A Kia, Raffaele Ferrari, Ganna Leonenko, Beatrice Costa, Valentina Saba, Edwin Jabbari, Manuela Mx Tan, Diego Albani, Victoria Alvarez, Ignacio Alvarez, Ole A Andreassen, Antonella Angiolillo, Andrea Arighi, Matt Baker, Luisa Benussi, Valentina Bessi, Giuliano Binetti, Daniel J Blackburn, Merce Boada, Bradley F Boeve, Sergi Borrego-Ecija, Barbara Borroni, Geir Bråthen, William S Brooks, Amalia C Bruni, Paola Caroppo, Sara Bandres-Ciga, Jordi Clarimon, Rosanna Colao, Carlos Cruchaga, Adrian Danek, Sterre Cm de Boer, Itziar de Rojas, Alfonso di Costanzo, Dennis W Dickson, Janine Diehl-Schmid, Carol Dobson-Stone, Oriol Dols-Icardo, Aldo Donizetti, Elise Dopper, Elisabetta Durante, Camilla Ferrari, Gianluigi Forloni, Francesca Frangipane, Laura Fratiglioni, Milica G Kramberger, Daniela Galimberti, Maurizio Gallucci, Pablo García-González, Roberta Ghidoni, Giorgio Giaccone, Caroline Graff, Neill R Graff-Radford, Jordan Grafman, Glenda M Halliday, Dena G Hernandez, Lena E Hjermind, John R Hodges, Guy Holloway, Edward D Huey, Ignacio Illán-Gala, Keith A Josephs, David S Knopman, Mark Kristiansen, John B Kwok, Isabelle Leber, Hampton L Leonard, Ilenia Libri, Alberto Lleo, Ian R Mackenzie, Gaganjit K Madhan, Raffaele Maletta, Marta Marquié, Ales Maver, Manuel Menendez-Gonzalez, Graziella Milan, Bruce L Miller, Christopher M Morris, Huw R Morris, Benedetta Nacmias, Judith Newton, Jørgen E Nielsen, Christer Nilsson, Valeria Novelli, Alessandro Padovani, Suvankar Pal, Florence Pasquier, Pau Pastor, Robert Perneczky, Borut Peterlin, Ronald C Petersen, Olivier Piguet, Yolande Al Pijnenburg, Annibale A Puca, Rosa Rademakers, Innocenzo Rainero, Lianne M Reus, Anna Mt Richardson, Matthias Riemenschneider, Ekaterina Rogaeva, Boris Rogelj, Sara Rollinson, Howard Rosen, Giacomina Rossi, James B Rowe, Elisa Rubino, Agustin Ruiz, Erika Salvi, Raquel Sanchez-Valle, Sigrid Botne Sando, Alexander F Santillo, Jennifer A Saxon, Johannes Cm Schlachetzki, Sonja W Scholz, Harro Seelaar, William W Seeley, Maria Serpente, Sandro Sorbi, Sabrina Sordon, Peter St George-Hyslop, Jennifer C Thompson, Christine Van Broeckhoven, Vivianna M Van Deerlin, Sven J Van der Lee, John Van Swieten, Fabrizio Tagliavini, Julie van der Zee, Arianna Veronesi, Emilia Vitale, Maria Landqvist Waldo, Jennifer S Yokoyama, Mike A Nalls, Parastoo Momeni, Andrew B Singleton, John Hardy, Valentina Escott-Price
Genome-wide analyses reveal a potential role for the MAPT, MOBP, and APOE loci in sporadic frontotemporal dementia.