Amanda Heslegrave

Dr Amanda Heslegrave

Principal Research Fellow

Co-leading the UK DRI Biomarker Factory platform based at UK DRI at UCL

Biography

Dr. Amanda Heslegrave is Principal Research Fellow at the UK DRI at UCL, where she co-leads the fluid biomarker (Zetterberg) laboratory and the UK DRI Biomarker Factory. After completing her BSc from Birkbeck, University of London (2000) and PhD from UCL (2005), she transitioned to biomarker research in 2012 with Prof Henrik Zetterberg at UCL. Her research focuses on fluid biomarkers in CSF and blood, utilising immunoassay and proteomic methods to study neurodegenerative diseases. 

News

Key publications

Multiple sclerosis (Houndmills, Basingstoke, England)
Published
Biomarker discovery using NUcleic Acid-Linked Immuno-Sandwich Assay in multiple sclerosis patients experiencing progression independent of relapse activity
Authors
Sofia Sandgren, Aleksandra Maleska Maceski, Pascal Benkert, Maximilian Einsiedler, Sabine Schaedelin, Johanna Oechtering, Lutz Achtnichts, Patrice H Lalive, Stefanie Müller, Caroline Pot, Amanda Heslegrave, David Hunt, Jan Lycke, Robert Hoepner, Patrick Roth, Claudio Gobbi, Manuel Comabella, Tobias Derfuss, Ludwig Kappos, Cristina Granziera, Ahmed Abdelhak, David Leppert, Eline Aj Willemse, Henrik Zetterberg, Jens Kuhle
Biomarker discovery using NUcleic Acid-Linked Immuno-Sandwich Assay in multiple sclerosis patients experiencing progression independent of relapse activity
The Lancet regional health. Europe
Published
Progression of biological markers in spinocerebellar ataxia type 3: longitudinal analysis of prospective data from the ESMI cohort
Authors
Moritz Berger, Hector Garcia-Moreno, Mónica Ferreira, Jeannette Hubener-Schmid, Tamara Schaprian, Philipp Wegner, Tim Elter, Kennet M Teichmann, Magda M Santana, Marcus Grobe-Einsler, Demet Oender, Berkan S C Koyak, Sarah Bernsen, Luís Pereira de Almeida, Patrick Silva, Joana Afonso Ribeiro, Inês Cunha, Cristina Gonzalez-Robles, Shamsher Khan, Amanda Heslegrave, Henrik Zetterberg, Manuela Lima, Mafalda Raposo, Ana F Ferreira, João Vasconcelos, Bart P van de Warrenburg, Judith van Gaalen, Teije H van Prooije, Jeroen de Vries, Ludger Schols, Olaf Riess, Matthis Synofzik, Dagmar Timmann, Andreas Thieme, Friedrich Erdlenbruch, Jon Infante, Ana L Pelayo-Negro, Leire Manrique, Kathrin Reetz, Imis Dogan, Gulin Oz, James M Joers, Khalafalla Bushara, Chiadikaobi Onyike, Michal Povazan, Heike Jacobi, Jeremy D Schmahmann, Eva-Maria Ratai, Matthias Schmid, Paola Giunti, Thomas Klockgether, Jennifer Faber
Progression of biological markers in spinocerebellar ataxia type 3: longitudinal analysis of prospective data from the ESMI cohort
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Identifying subphenotypes of patients undergoing post-operative delirium assessment
Authors
Emily Margaret Louise Bowman, Daniel F McAuley, Bernadette McGuinness, Anthony P Passmore, David Beverland, Henrik Zetterberg, Jonathan M Schott, Amanda Heslegrave, Elena Veleva, Rhiannon Laban, Aoife Sweeney, Emma L Cunningham
Identifying subphenotypes of patients undergoing post-operative delirium assessment
Journal of neurology
Published
Evaluating finger-prick blood collection for remote quantification of neurofilament light in neurological diseases
Authors
Annabelle Coleman, Alexiane Touzé, Mena Farag, Marta Pengo, Michael J Murphy, Yara Hassan, Olivia Thackeray, Kate Fayer, Sophie Field, Mitsuko Nakajima, Elizabeth L Broom, Nicola Z Hobbs, Brook Huxford, Natalie Donkor, Ellen Camboe, Kamalesh C Dey, Alexandra Zirra, Aisha Ahmed, Ana Rita Gameiro Costa, Harriet Sorrell, Luca Zampedri, Vittoria Lombardi, Charles Wade, Sean Mangion, Batoul Fneich, Amanda Heslegrave, Henrik Zetterberg, Rachael Scahill, Alastair Noyce, Andrea Malaspina, Jeremy Chataway, Sarah J Tabrizi, Lauren M Byrne
Evaluating finger-prick blood collection for remote quantification of neurofilament light in neurological diseases

The Biomarker Factory

Dr Amanda Heslegrave co-leads the UK DRI Biomarker Factory, transforming the early detection, diagnosis and monitoring of dementia, by facilitating the development of fluid biomarkers for research and the clinic

UK DRI Biomarker Factory
Scientists posing in the lab in white coats