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Dr Hilde van den Brink

(She/Her)

Postdoctoral Researcher

Identifying the mechanisms that drive brain haemorrhages in CAA, with a broader interest in shared disease mechanisms across cerebral small vessel diseases.

Techniques

Statistical modelling, Spatial transcriptomics, Human brain imaging

Biography

Hilde joined the UKDRI in January 2026 when she started working at the Translational CAA Research Lab at the University of Edinburgh. She trained as a neuropsychologist and neuroscientist in the Netherlands, where she obtained her PhD at Utrecht University. She subsequently moved to Boston for her postdoctoral training with Dr. Susanne van Veluw at Massachusetts General Hospital and Harvard Medical School. Hilde joined the lab’s transition to the University of Edinburgh, where her research focuses on identifying the mechanisms that drive brain haemorrhages in CAA, with a broader interest in shared disease mechanisms across cerebral small vessel diseases. Her current work centres on the roles of blood–brain barrier dysfunction and neuroinflammatory responses in vascular injury and haemorrhage. In addition to her research, Hilde is passionate about ensuring that scientific findings are meaningfully communicated to patients and caregivers. She is actively involved in international patient communication initiatives through the International CAA Association and aims to contribute to the development of a patient advisory board for the association. In her free time, Hilde enjoys biking, music concerts, reading and gardening – even more so in the company of friends.

Honours & awards

Hilde's current research is funded by an early career researcher grant from Alzheimer Nederland ‘Identifying consequences of blood-brain barrier leakage in small vessel diseases’, project number WE.03-2025-23

Previous funding:

  • Impuls grant from Alzheimer Nederland 'Unravelling the role of blood brain barrier leakage in cerebral amyloid angiopathy', project number WE.06-2023-11. This grant supported two years of postdoctoral research at Massachusetts General Hospital and Harvard Medical School
  • CVON Heart-Brain connection young talent grant 'Impact of haemodynamics along the heart brain axis on cerebral microinfarcts'. This grant supported one project of Hilde's PhD work.
  • Several scholarships together supported a 7-month international research internship in Calgary, Canada: Alzheimer Nederland, Stichting Korinthiers, Jo Kolk studiefonds, Stichting SSVO, Hendrik Muller fonds, Stichting fundatie van de Vrijvrouwe van Renswoude and kfHein fonds.

Key publications

Lancet Neurol
Published

Effect of blood pressure-lowering agents on microvascular function in people with small vessel diseases (TREAT-SVDs): a multicentre, open-label, randomised, crossover trial.

Authors
Anna Kopczak, Michael S Stringer, Hilde van den Brink, Danielle Kerkhofs, Gordon W Blair, Maud van Dinther, Carmen Arteaga Reyes, Daniela Jaime Garcia, Laurien Onkenhout, Karolina A Wartolowska, Michael J Thrippleton, Agniete Kampaite, Marco Duering, Julie Staals, Saskia Lesnik-Oberstein, Keith W Muir, Martin Middeke, Bo Norrving, Marie-Germaine Bousser, Ulrich Mansmann, Peter M Rothwell, Fergus N Doubal, Robert van Oostenbrugge, Geert Jan Biessels, Alastair J S Webb, Joanna M Wardlaw, Martin Dichgans
Effect of blood pressure-lowering agents on microvascular function in people with small vessel diseases (TREAT-SVDs): a multicentre, open-label, randomised, crossover trial.
Int J Stroke
Published

The global burden of cerebral small vessel disease in low- and middle-income countries: A systematic review and meta-analysis.

Authors
Bonnie Yin Ka Lam, Yuan Cai, Rufus Akinyemi, Geert Jan Biessels, Hilde van den Brink, Christopher Chen, Chin Wai Cheung, King Ngai Chow, Henry Kwun Hang Chung, Marco Duering, Siu Ting Fu, Deborah Gustafson, Saima Hilal, Vincent Ming Ho Hui, Rajesh Kalaria, SangYun Kim, Maggie Li Man Lam, Frank Erik de Leeuw, Ami Sin Man Li, Hugh Stephen Markus, Anna Marseglia, Huijing Zheng, John O'Brien, Leonardo Pantoni, Perminder Singh Sachdev, Eric E Smith, Joanna Wardlaw, Vincent Chung Tong Mok
The global burden of cerebral small vessel disease in low- and middle-income countries: A systematic review and meta-analysis.
Ann Neurol
Published

CADASIL Affects Multiple Aspects of Cerebral Small Vessel Function on 7T-MRI.

Authors
Hilde van den Brink, Anna Kopczak, Tine Arts, Laurien Onkenhout, Jeroen C W Siero, Jaco J M Zwanenburg, Sandra Hein, Mathias Hübner, Benno Gesierich, Marco Duering, Michael S Stringer, Jeroen Hendrikse, Joanna M Wardlaw, Anne Joutel, Martin Dichgans, Geert Jan Biessels
CADASIL Affects Multiple Aspects of Cerebral Small Vessel Function on 7T-MRI.