Prof Sir John Hardy

Group Leader

Harnessing genetics to build a better understanding of dementia

Condition

Alzheimer's disease, Parkinson's disease

Topics

Genetics

Biography

Prof Sir John Hardy is a world-leading neurogeneticist in the field of neurodegenerative diseases, receiving numerous accolades that include the Breakthrough Prize in Life Sciences, the Brain Prize, election as a Fellow of the Royal Society and, in 2022, a knighthood for his contributions to science and health. In 1991, Hardy's team uncovered the first mutation directly implicated in Alzheimer's disease leading to the formulation of the highly influential 'amyloid-cascade' hypothesis. His extensive body of work in genetics will be built upon in this UK DRI programme, where the team will unravel pathogenic networks in neurodegenerative disease.

News

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Discussing diversity in dementia research

How health inequalities are impacting people with dementia, and how research can help to address...

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Key publications

Nature structural & molecular biology
Published
African ancestry neurodegeneration risk variant disrupts an intronic branchpoint in GBA1
Authors
Pilar Álvarez Jerez, Peter Wild Crea, Daniel M Ramos, Emil K Gustavsson, Mandy Radefeldt, Andrey Damianov, Mary B Makarious, Oluwadamilola O Ojo, Kimberley J Billingsley, Laksh Malik, Kensuke Daida, Sarah Bromberek, Fangle Hu, Zachary Schneider, Aditya L Surapaneni, Julia Stadler, Mie Rizig, Huw R Morris, Caroline B Pantazis, Hampton L Leonard, Laurel Screven, Yue A Qi, Mike A Nalls, Sara Bandres-Ciga, John Hardy, Henry Houlden, Celeste Eng, Esteban González Burchard, Linda Kachuri, Chia-Ho Lin, Douglas L Black, Global Parkinson’s Genetics Program (GP2), Andrew B Singleton, Steffen Fischer, Peter Bauer, Xylena Reed, Mina Ryten, Christian Beetz, Michael Ward, Njideka U Okubadejo, Cornelis Blauwendraat
African ancestry neurodegeneration risk variant disrupts an intronic branchpoint in GBA1
Movement disorders : official journal of the Movement Disorder Society
Published
The ZFHX3 GGC Repeat Expansion Underlying Spinocerebellar Ataxia Type 4 has a Common Ancestral Founder
Authors
Zhongbo Chen, Pilar Alvarez Jerez, Claire Anderson, Martin Paucar, Jasmaine Lee, Daniel Nilsson, Hannah Macpherson, Annarita Scardamaglia, Kylie Montgomery, John Hardy, Andrew B Singleton, Arianna Tucci, Katherine D Mathews, Ying-Hui Fu, Martin Engvall, José Laffita-Mesa, Inger Nennesmo, Anna Wedell, Louis J Ptáček, Cornelis Blauwendraat, Emil K Gustavsson, Per Svenningsson, Mina Ryten, Henry Houlden
The ZFHX3 GGC Repeat Expansion Underlying Spinocerebellar Ataxia Type 4 has a Common Ancestral Founder
bioRxiv : the preprint server for biology
Published
Age- and amyloid-β-dependent initiation of neurofibrillary tau tangles: an improved mouse model of Alzheimer's disease without mutations in <em>MAPT</em>
Authors
Sneha Desai, Elena Camporesi, Gunnar Brinkmalm, Argyro Alatza, Jack I Wood, Takshashila Tripathi, Sumi Bez, Nazar Stasyuk, Haady B Hajar, Takashi Saito, Takaomi C Saido, John Hardy, Damian M Cummings, Jörg Hanrieder, Frances A Edwards
Age- and amyloid-β-dependent initiation of neurofibrillary tau tangles: an improved mouse model of Alzheimer's disease without mutations in <em>MAPT</em>

Hardy Lab

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Hardy Lab