Image of Marc-David Ruepp

Prof Marc-David Ruepp

Group Leader

Exploring RNA metabolism in health and neurodegeneration

Condition

Motor neuron disease/ALS, Frontotemporal dementia

Topics

Cell biology of neurons & glia, Molecular mechanisms, Treatments & Interventions

Techniques

Advanced microscopy & imaging, Biophysical techniques, CRISPR, Next generation sequencing, Stem cells / iPSCs, Viral-mediated expression

Biography

Marc-David Ruepp is a Professor of RNA Biology and Molecular Neurodegeneration at the UK Dementia Research Institute (UK DRI) at King’s College London. His laboratory is interested in RNA metabolism in health and disease with a specific focus on neurodegeneration. He received his PhD in 2009 (Graduate School of Cellular and Biomedical Sciences, University of Bern) and started his independent scientific career as Junior Group Leader in 2014 in the Department of Chemistry and Biochemistry at the University of Bern, Switzerland. He habilitated at the Faculty of Science, University of Bern, and received his Venia Docendi in RNA biology in 2018. The same year he joined the UK DRI as Group Leader and King’s College London as Senior Lecturer in Neuroscience. In 2022 he was promoted to Reader and in 2025 to Professor of RNA Biology and Molecular Neurodegeneration.

News

Key publications

Cell reports
Published
A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neurons
Authors
Benedikt V Hölbling, Yashica Gupta, Paolo M Marchi, Magda L Atilano, Michael Flower, Enric Ureña, Rajkumar A Goulden, Hannah K Dobbs, Eszter Katona, Alla Mikheenko, Ashling Giblin, Ali Raza Awan, Chloe L Fisher-Ward, Niamh O'Brien, Deniz Vaizoglu, Liam Kempthorne, Katherine M Wilson, Lauren M Gittings, Mireia Carcolé, Marc-David Ruepp, Sarah Mizielinska, Linda Partridge, Pietro Fratta, Sarah J Tabrizi, Bhuvaneish T Selvaraj, Siddharthan Chandran, Emma Armstrong, Paul Whiting, Adrian M Isaacs
A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neurons
EMBO J
Published
HNRNPH1 regulates the neuroprotective cold-shock protein RBM3 expression through poison exon exclusion.
Authors
Julie Qiaojin Lin, Deepak Khuperkar, Sofia Pavlou, Stanislaw Makarchuk, Nikolaos Patikas, Flora Cy Lee, Julia M Zbiegly, Jianning Kang, Sarah F Field, David Md Bailey, Joshua L Freeman, Jernej Ule, Emmanouil Metzakopian, Marc-David Ruepp, Giovanna R Mallucci
HNRNPH1 regulates the neuroprotective cold-shock protein RBM3 expression through poison exon exclusion.

Ruepp Lab

Explore the work of the Ruepp Lab, exploring RNA metabolism in health and disease with a specific focus on neurodegeneration

Ruepp Lab
Cytoplasmic mutant TAF15 engulfs U12 snRNAs in the cytoplasm of HeLa cells