Tim Bartels

Dr Tim Bartels

((he/him))

Group Leader

Untangling protein structure to better understand function and treat neurodegeneration

Condition

Parkinson's disease, Lewy body dementia

Topics

Cell biology of neurons & glia, Immune system, Molecular mechanisms, Biomarkers & diagnostics, Treatments & Interventions

Techniques

Advanced microscopy & imaging, Advanced spectroscopy, Biophysical techniques, Experimental medicine, Flow cytometry, Fluid biomarkers, Lipidomics, Mass spec-based proteomics, Stem cells / iPSCs, Structural biology, Viral-mediated expression

Biography

Dr. Tim Bartels initially finished his MSc in Chemistry and Medical Engineering in 2005 at the Technical University Munich. In 2008 he received his PhD in Biophysics working at the Adolf Butenandt Institute (Director Christian Haass) at the Ludwig-Maximilian University (supervisors Johannes Buchner and Klaus Beyer). He completed his postdoctoral training at the Center for Neurologic Diseases/Harvard Medical School with Dennis Selkoe in 2011, where he also held his first faculty positions (Instructor of Neurology 2012-2016, assistant professor 2016-2019). 

Since 2018 he is leading the program “Structure-Function Relationship in Neurodegeneration” at the Dementia Research Institute at the University College London. His lab is dedicated to the involvement of the different forms of the presynaptic protein alpha-synuclein in Parkinson’s Disease and Dementia with Lewy Bodies. Furthermore, his lab is interested in novel context specific pathways of protein folding/misfolding and the involvement of lipids, non-neuronal cells and the gut-brain axis in neurodegeneration.   

News

Key publications

Neuron
Published
Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions.
Authors
Isabel Lam, Alain Ndayisaba, Amanda J Lewis, YuHong Fu, Giselle T Sagredo, Anastasia Kuzkina, Ludovica Zaccagnini, Meral Celikag, Jackson Sandoe, Ricardo L Sanz, Aazam Vahdatshoar, Timothy D Martin, Nader Morshed, Toru Ichihashi, Arati Tripathi, Nagendran Ramalingam, Charlotte Oettgen-Suazo, Theresa Bartels, Manel Boussouf, Max Schäbinger, Erinc Hallacli, Xin Jiang, Amrita Verma, Challana Tea, Zichen Wang, Hiroyuki Hakozaki, Xiao Yu, Kelly Hyles, Chansaem Park, Xinyuan Wang, Thorold W Theunissen, Haoyi Wang, Rudolf Jaenisch, Susan Lindquist, Beth Stevens, Nadia Stefanova, Gregor Wenning, Wilma D J van de Berg, Kelvin C Luk, Rosario Sanchez-Pernaute, Juan Carlos Gómez-Esteban, Daniel Felsky, Yasujiro Kiyota, Nidhi Sahni, S Stephen Yi, Chee Yeun Chung, Henning Stahlberg, Isidro Ferrer, Johannes Schöneberg, Stephen J Elledge, Ulf Dettmer, Glenda M Halliday, Tim Bartels, Vikram Khurana
Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions.
Acta Neuropathol
Published
Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations.
Authors
Laura de Boni, Aurelia Hays Watson, Ludovica Zaccagnini, Amber Wallis, Kristina Zhelcheska, Nora Kim, John Sanderson, Haiyang Jiang, Elodie Martin, Adam Cantlon, Matteo Rovere, Lei Liu, Marc Sylvester, Tammaryn Lashley, Ulf Dettmer, Zane Jaunmuktane, Tim Bartels
Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations.

Bartels Lab

Explore the work of the Bartels Lab focused on untangling protein structure to better understand function and treat neurodegeneration

Bartels Lab
PET tracer imaging from the Bartels Lab