Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

Cytokines released by T cells after encountering cancer cells

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system
medRxiv : the preprint server for health sciences
Published
Sample size estimates for biomarker-based outcome measures in clinical trials in autosomal dominant Alzheimer's disease
Authors
David M Cash, Katy E Morgan, Antoinette O'Connor, Thomas D Veale, Ian B Malone, Teresa Poole, Tammie Ls Benzinger, Brian A Gordon, Laura Ibanez, Yan Li, Jorge J Llibre-Guerra, Eric McDade, Guoqiao Wang, Jasmeer P Chhatwal, Gregory S Day, Edward Huey, Mathias Jucker, Johannes Levin, Yoshiki Niimi, James M Noble, Jee Hoon Roh, Racquel Sánchez-Valle, Peter R Schofield, Randall J Bateman, Chris Frost, Nick C Fox, Dominantly Inherited Alzheimer Network (DIAN)
Sample size estimates for biomarker-based outcome measures in clinical trials in autosomal dominant Alzheimer's disease
Neurobiology of aging
Published
Cerebral white matter hyperintensity volumes: Normative age- and sex-specific values from 15 population-based cohorts comprising 14,876 individuals
Authors
Floor A S de Kort, Elisabeth J Vinke, Ewoud J van der Lelij, Devasuda Anblagan, Mark E Bastin, Alexa Beiser, Henry Brodaty, Nishi Chaturvedi, Bastian Cheng, Simon R Cox, Charles DeCarli, Christian Enzinger, Evan Fletcher, Richard Frayne, Marius de Groot, Felicia Huang, M Arfan Ikram, Jiyang Jiang, Bonnie Y K Lam, Pauline Maillard, Carola Mayer, Cheryl R McCreary, Vincent Mok, Susana Muñoz Maniega, Marvin Petersen, Genady Roshchupkin, Perminder S Sachdev, Reinhold Schmidt, Stephan Seiler, Sudha Seshadri, Carole H Sudre, Götz Thomalla, Raphael Twerenbold, Maria Valdés Hernández, Meike W Vernooij, Joanna M Wardlaw, Wei Wen, Hugo J Kuijf, Geert Jan Biessels, J Matthijs Biesbroek
Cerebral white matter hyperintensity volumes: Normative age- and sex-specific values from 15 population-based cohorts comprising 14,876 individuals
Cell reports
Published
Development of MAPT S305 mutation human iPSC lines exhibiting elevated 4R tau expression and functional alterations in neurons and astrocytes
Authors
Kathryn R Bowles, Chiara Pedicone, Derian A Pugh, Laura-Maria Oja, Filipa H Sousa, Lois K Keavey, Brian Fulton-Howard, Sarah A Weitzman, Yiyuan Liu, Jonathan L Chen, Matthew D Disney, Alison M Goate
Development of MAPT S305 mutation human iPSC lines exhibiting elevated 4R tau expression and functional alterations in neurons and astrocytes
British journal of cancer
Published
Associations of blood lipids and LDL cholesterol lowering drug-targets with colorectal cancer risk: a Mendelian randomisation study
Authors
Wing Ching Chan, Lili Liu, Emmanouil Bouras, Verena Zuber, Wanqing Wen, Jirong Long, Dipender Gill, Neil Murphy, Marc J Gunter, Themistocles L Assimes, Luis Bujanda, Stephen B Gruber, Sébastien Küry, Brigid M Lynch, Conghui Qu, Minta Thomas, Emily White, Michael O Woods, Ulrike Peters, Christopher I Li, Andrew T Chan, Hermann Brenner, Konstantinos K Tsilidis, Wei Zheng
Associations of blood lipids and LDL cholesterol lowering drug-targets with colorectal cancer risk: a Mendelian randomisation study
Alzheimer's research & therapy
Published
Elevated plasma p-tau231 is associated with reduced generalization and medial temporal lobe dynamic network flexibility among healthy older African Americans
Authors
Miray Budak, Bernadette A Fausto, Zuzanna Osiecka, Mustafa Sheikh, Robert Perna, Nicholas Ashton, Kaj Blennow, Henrik Zetterberg, Patricia Fitzgerald-Bocarsly, Mark A Gluck
Elevated plasma p-tau231 is associated with reduced generalization and medial temporal lobe dynamic network flexibility among healthy older African Americans
The Lancet. Neurology
Published
Sensitivity and specificity of a seed amplification assay for diagnosis of multiple system atrophy: a multicentre cohort study
Authors
Yihua Ma, Carly M Farris, Sandrina Weber, Sebastian Schade, Hieu Nguyen, Alexandra Pérez-Soriano, Darly M Giraldo, Manel Fernández, Marta Soto, Ana Cámara, Celia Painous, Esteban Muñoz, Francesc Valldeoriola, Maria J Martí, Jordi Clarimon, Pekka Kallunki, Thong Chi Ma, Roy N Alcalay, Bárbara Fernandez Gomes, Kaj Blennow, Henrik Zetterberg, Julius Constantinescu, David Mengel, Vaibhavi Kadam, Piero Parchi, Kathrin Brockmann, Thomas F Tropea, Andrew Siderowf, Matthis Synofzik, Un Jung Kang, Yaroslau Compta, Per Svenningsson, Brit Mollenhauer, Luis Concha-Marambio
Sensitivity and specificity of a seed amplification assay for diagnosis of multiple system atrophy: a multicentre cohort study
Journal of the neurological sciences
Published
Plasma neurofilament light outperforms glial fibrillary acidic protein in differentiating behavioural variant frontotemporal dementia from primary psychiatric disorders
Authors
Dhamidhu Eratne, Matthew J Y Kang, Courtney Lewis, Christa Dang, Charles Malpas, Suyi Ooi, Amy Brodtmann, David Darby, Henrik Zetterberg, Kaj Blennow, Michael Berk, Olivia Dean, Chad Bousman, Naveen Thomas, Ian Everall, Chris Pantelis, Cassandra Wannan, Claudia Cicognola, Oskar Hansson, Shorena Janelidze, Alexander F Santillo, Dennis Velakoulis, MiND Study Group
Plasma neurofilament light outperforms glial fibrillary acidic protein in differentiating behavioural variant frontotemporal dementia from primary psychiatric disorders
bioRxiv : the preprint server for biology
Published
Lifetime brain atrophy estimated from a single MRI: measurement characteristics and genome-wide correlates
Authors
Anna E Fürtjes, Isabelle F Foote, Charley Xia, Gail Davies, Joanna Moodie, Adele Taylor, David C Liewald, Paul Redmond, Janie Corley, Andrew M McIntosh, Heather C Whalley, Susana Muñoz Maniega, Maria Valdés Hernández, Ellen Backhouse, Karen Ferguson, Mark E Bastin, Joanna Wardlaw, Javier de la Fuente, Andrew D Grotzinger, Michelle Luciano, W David Hill, Ian J Deary, Elliot M Tucker-Drob, Simon R Cox
Lifetime brain atrophy estimated from a single MRI: measurement characteristics and genome-wide correlates
medRxiv : the preprint server for health sciences
Published
Plasma p-tau212 as a biomarker of sporadic and Down Syndrome Alzheimer's disease
Authors
Przemysław R Kac, Daniel Alcolea, Laia Montoliu-Gaya, Susana Fernández, Juan Lantero Rodriguez, Lucía Maure, Fernando González-Ortiz, Bessy Benejam, Michael Turton, Isabel Barroeta, Peter Harrison, Laura Videla, Nicholas J Ashton, Alberto Lleó, Henrik Zetterberg, María Carmona-Iragui, Thomas K Karikari, Juan Fortea, Kaj Blennow
Plasma p-tau212 as a biomarker of sporadic and Down Syndrome Alzheimer's disease
bioRxiv : the preprint server for biology
Published
Age- and amyloid-β-dependent initiation of neurofibrillary tau tangles: an improved mouse model of Alzheimer's disease without mutations in <em>MAPT</em>
Authors
Sneha Desai, Elena Camporesi, Gunnar Brinkmalm, Argyro Alatza, Jack I Wood, Takshashila Tripathi, Sumi Bez, Nazar Stasyuk, Haady B Hajar, Takashi Saito, Takaomi C Saido, John Hardy, Damian M Cummings, Jörg Hanrieder, Frances A Edwards
Age- and amyloid-β-dependent initiation of neurofibrillary tau tangles: an improved mouse model of Alzheimer's disease without mutations in <em>MAPT</em>
Nature neuroscience
Published
Tau filaments are tethered within brain extracellular vesicles in Alzheimer's disease
Authors
Stephanie L Fowler, Tiana S Behr, Emir Turkes, Darragh P O'Brien, Paula Maglio Cauhy, Isadora Rawlinson, Marisa Edmonds, Martha S Foiani, Ari Schaler, Gerard Crowley, Sumi Bez, Elena Ficulle, Eliona Tsefou, Roman Fischer, Beth Geary, Pallavi Gaur, Chelsea Miller, Pasquale D'Acunzo, Efrat Levy, Karen E Duff, Benjamin Ryskeldi-Falcon
Tau filaments are tethered within brain extracellular vesicles in Alzheimer's disease
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Visual read of [F-18]florquinitau PET that includes and extends beyond the mesial temporal lobe is associated with increased plasma pTau217 and cognitive decline in a cohort that is enriched with risk for Alzheimer's disease
Authors
Ramiro Eduardo Rea Reyes, Karly A Cody, Rachael E Wilson, Henrik Zetterberg, Nathaniel A Chin, Erin M Jonaitis, Melissa Bahr, Olivia Mandel, Madilynn Wintlend, Barbara B Bendlin, Ozioma C Okonkwo, Lindsay R Clark, Matt Zammit, Sanjay Asthana, Bradley T Christian, Tobey J Betthauser, Laura Eisenmenger, Rebecca E Langhough, Sterling C Johnson
Visual read of [F-18]florquinitau PET that includes and extends beyond the mesial temporal lobe is associated with increased plasma pTau217 and cognitive decline in a cohort that is enriched with risk for Alzheimer's disease