Skip to main content
Search
Main content
John Hardy

Prof Sir John Hardy

Group Leader

Harnessing genetics to build a better understanding of dementia

Biography

Prof Sir John Hardy is a world-leading neurogeneticist in the field of neurodegenerative diseases, receiving numerous accolades that include the Breakthrough Prize in Life Sciences, the Brain Prize, election as a Fellow of the Royal Society and, in 2022, a knighthood for his contributions to science and health. In 1991, Hardy's team uncovered the first mutation directly implicated in Alzheimer's disease leading to the formulation of the highly influential 'amyloid-cascade' hypothesis. His extensive body of work in genetics will be built upon in this UK DRI programme, where the team will unravel pathogenic networks in neurodegenerative disease.

News

Key publications

bioRxiv : the preprint server for biology
Published
Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson's disease
Authors
Elena Eubanks, Katelyn VanderSleen, Jiya Mody, Neha Patel, Benjamin Sacks, Mahsa Darestani Farahani, Jinying Wang, Jordan Elliott, Nora Jaber, Fulya Akçimen, Sara Bandres-Ciga, Fadel Helweh, Jun Liu, Sanjana Archakam, Robert Kimelman, Bineet Sharma, Philip Socha, Ananya Guntur, Tim Bartels, Ulf Dettmer, M Maral Mouradian, Amir Houshang Bahrami, Wei Dai, Jean Baum, Zheng Shi, John Hardy, Eleanna Kara
Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson's disease
The EMBO journal
Published
Author Correction: Microglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models
Authors
Javier Rueda-Carrasco, Dimitra Sokolova, Sang-Eun Lee, Thomas Childs, Natália Jurčáková, Gerard Crowley, Sebastiaan De Schepper, Judy Z Ge, Joanne I Lachica, Christina E Toomey, Oliver J Freeman, John Hardy, Samuel J Barnes, Tammaryn Lashley, Beth Stevens, Sunghoe Chang, Soyon Hong
Author Correction: Microglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models
Am J Hum Genet
Published
Genome-wide analyses reveal a potential role for the MAPT, MOBP, and APOE loci in sporadic frontotemporal dementia.
Authors
Claudia Manzoni, Demis A Kia, Raffaele Ferrari, Ganna Leonenko, Beatrice Costa, Valentina Saba, Edwin Jabbari, Manuela Mx Tan, Diego Albani, Victoria Alvarez, Ignacio Alvarez, Ole A Andreassen, Antonella Angiolillo, Andrea Arighi, Matt Baker, Luisa Benussi, Valentina Bessi, Giuliano Binetti, Daniel J Blackburn, Merce Boada, Bradley F Boeve, Sergi Borrego-Ecija, Barbara Borroni, Geir Bråthen, William S Brooks, Amalia C Bruni, Paola Caroppo, Sara Bandres-Ciga, Jordi Clarimon, Rosanna Colao, Carlos Cruchaga, Adrian Danek, Sterre Cm de Boer, Itziar de Rojas, Alfonso di Costanzo, Dennis W Dickson, Janine Diehl-Schmid, Carol Dobson-Stone, Oriol Dols-Icardo, Aldo Donizetti, Elise Dopper, Elisabetta Durante, Camilla Ferrari, Gianluigi Forloni, Francesca Frangipane, Laura Fratiglioni, Milica G Kramberger, Daniela Galimberti, Maurizio Gallucci, Pablo García-González, Roberta Ghidoni, Giorgio Giaccone, Caroline Graff, Neill R Graff-Radford, Jordan Grafman, Glenda M Halliday, Dena G Hernandez, Lena E Hjermind, John R Hodges, Guy Holloway, Edward D Huey, Ignacio Illán-Gala, Keith A Josephs, David S Knopman, Mark Kristiansen, John B Kwok, Isabelle Leber, Hampton L Leonard, Ilenia Libri, Alberto Lleo, Ian R Mackenzie, Gaganjit K Madhan, Raffaele Maletta, Marta Marquié, Ales Maver, Manuel Menendez-Gonzalez, Graziella Milan, Bruce L Miller, Christopher M Morris, Huw R Morris, Benedetta Nacmias, Judith Newton, Jørgen E Nielsen, Christer Nilsson, Valeria Novelli, Alessandro Padovani, Suvankar Pal, Florence Pasquier, Pau Pastor, Robert Perneczky, Borut Peterlin, Ronald C Petersen, Olivier Piguet, Yolande Al Pijnenburg, Annibale A Puca, Rosa Rademakers, Innocenzo Rainero, Lianne M Reus, Anna Mt Richardson, Matthias Riemenschneider, Ekaterina Rogaeva, Boris Rogelj, Sara Rollinson, Howard Rosen, Giacomina Rossi, James B Rowe, Elisa Rubino, Agustin Ruiz, Erika Salvi, Raquel Sanchez-Valle, Sigrid Botne Sando, Alexander F Santillo, Jennifer A Saxon, Johannes Cm Schlachetzki, Sonja W Scholz, Harro Seelaar, William W Seeley, Maria Serpente, Sandro Sorbi, Sabrina Sordon, Peter St George-Hyslop, Jennifer C Thompson, Christine Van Broeckhoven, Vivianna M Van Deerlin, Sven J Van der Lee, John Van Swieten, Fabrizio Tagliavini, Julie van der Zee, Arianna Veronesi, Emilia Vitale, Maria Landqvist Waldo, Jennifer S Yokoyama, Mike A Nalls, Parastoo Momeni, Andrew B Singleton, John Hardy, Valentina Escott-Price
Genome-wide analyses reveal a potential role for the MAPT, MOBP, and APOE loci in sporadic frontotemporal dementia.
Brain communications
Published
Investigation of the genetic aetiology of Lewy body diseases with and without dementia
Authors
Lesley Yue Wu, Raquel Real, Alejandro Martinez-Carrasco, Ruth Chia, Michael A Lawton, Maryam Shoai, Catherine Bresner, Cornelis Blauwendraat, Andrew B Singleton, Mina Ryten, International Lewy Body Dementia Genomics Consortium, Sonja W Scholz, Bryan J Traynor, Nigel M Williams, Michele T M Hu, Yoav Ben-Shlomo, Donald G Grosset, John Hardy, Huw R Morris
Investigation of the genetic aetiology of Lewy body diseases with and without dementia

Hardy Lab

Explore the work of the Hardy Lab, harnessing genetics to build a better understanding of dementia