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Jan 17, 2025 - Research

Brain changes in Huntington’s disease occur decades before diagnosis

Subtle changes in the brain happen approximately twenty years before a clinical motor diagnosis in people with Huntington’s disease, finds a new study led by...

Learn more Brain changes in Huntington’s disease occur decades before diagnosis

Jan 08, 2025 - Research

Genetic changes in brain cells link ageing and Alzheimer’s

Genetic differences that contribute to how long a person will live and their risk of Alzheimer’s disease have been identified in a new study led...

Learn more Genetic changes in brain cells link ageing and Alzheimer’s

Phospho-tau accumulation in MAPT knockout mice

Jan 08, 2025 - Research

Brain damage starts before tau protein clumps in frontotemporal dementia and Alzheimer’s

A new study led by Prof Karen Duff, Dr Naoto Watamura, and Dr Martha Foiani (UK DRI at UCL), with Prof Takaomi Saido (Riken Center...

Learn more Brain damage starts before tau protein clumps in frontotemporal dementia and Alzheimer’s

Nature

Published Jan 22, 1998

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein.

Authors

B De Strooper, P Saftig, K Craessaerts, H Vanderstichele, G Guhde, W Annaert, K Von Figura, F Van Leuven

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein.

EMBO J

Published Apr 03, 1995

The solution structure of the RING finger domain from the acute promyelocytic leukaemia proto-oncoprotein PML.

Authors

K L Borden, M N Boddy, J Lally, N J O'Reilly, S Martin, K Howe, E Solomon, P S Freemont

The solution structure of the RING finger domain from the acute promyelocytic leukaemia proto-oncoprotein PML.

Ann N Y Acad Sci

Published Jun 11, 1993

The RING finger. A novel protein sequence motif related to the zinc finger.

Authors

P S Freemont

The RING finger. A novel protein sequence motif related to the zinc finger.

Science

Published Nov 29, 1991

Characterization of a zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia.

Authors

A D Goddard, J Borrow, P S Freemont, E Solomon

Characterization of a zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia.

Nature

Published Feb 21, 1991

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease.

Authors

A Goate, M C Chartier-Harlin, M Mullan, J Brown, F Crawford, L Fidani, L Giuffra, A Haynes, N Irving, L James

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease.

Science

Published Aug 03, 1990

A family of AMPA-selective glutamate receptors.

Authors

K Keinänen, W Wisden, B Sommer, P Werner, A Herb, T A Verdoorn, B Sakmann, P H Seeburg

A family of AMPA-selective glutamate receptors.

Nature

Published Sep 29, 1988

Electrogenic glutamate uptake in glial cells is activated by intracellular potassium.

Authors

B Barbour, H Brew, D Attwell

Electrogenic glutamate uptake in glial cells is activated by intracellular potassium.

Science

Published Apr 08, 1988

Genetic and crystallographic studies of the 3',5'-exonucleolytic site of DNA polymerase I.

Authors

V Derbyshire, P S Freemont, M R Sanderson, L Beese, J M Friedman, C M Joyce, T A Steitz

Genetic and crystallographic studies of the 3',5'-exonucleolytic site of DNA polymerase I.

J R Soc Interface

Published Jan 01, 1970

Neurodegenerative disease of the brain: a survey of interdisciplinary approaches.

Authors

Franca Davenport, John Gallacher, Zoe Kourtzi, Ivan Koychev, Paul M Matthews, Neil P Oxtoby, Laura M Parkes, Viola Priesemann, James B Rowe, Stephen W Smye, Henrik Zetterberg

Neurodegenerative disease of the brain: a survey of interdisciplinary approaches.

J Sleep Res

Published Jan 01, 1970

Bedtime to the brain: how infants' sleep behaviours intertwine with non-rapid eye movement sleep electroencephalography features.

Authors

Sarah F Schoch, Valeria Jaramillo, Andjela Markovic, Reto Huber, Malcolm Kohler, Oskar G Jenni, Caroline Lustenberger, Salome Kurth

Bedtime to the brain: how infants' sleep behaviours intertwine with non-rapid eye movement sleep electroencephalography features.

Ann Neurol

Published Jan 01, 1970

Thalamic Influence on Slow Wave Slope Renormalization During Sleep.

Authors

Valeria Jaramillo, Jasmine Jendoubi, Angelina Maric, Armand Mensen, Natalie C Heyse, Aleksandra K Eberhard-Moscicka, Roland Wiest, Claudio L A Bassetti, Reto Huber

Thalamic Influence on Slow Wave Slope Renormalization During Sleep.

Acta Neuropathol

Published Jan 01, 1970

Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson's disease pathogenesis.

Authors

Craig D Hughes, Minee L Choi, Mina Ryten, Lee Hopkins, Anna Drews, Juan A Botía, Maria Iljina, Margarida Rodrigues, Sarah A Gagliano, Sonia Gandhi, Clare Bryant, David Klenerman

Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson's disease pathogenesis.

J Cereb Blood Flow Metab

Published Jan 01, 1970

An energy budget for signaling in the grey matter of the brain.

Authors

D Attwell, S B Laughlin

An energy budget for signaling in the grey matter of the brain.

Radiology

Published Jan 01, 1970

Rapid Short-pulse Ultrasound Delivers Drugs Uniformly across the Murine Blood-Brain Barrier with Negligible Disruption.

Authors

Sophie V Morse, Antonios N Pouliopoulos, Tiffany G Chan, Matthew J Copping, Julien Lin, Nicholas J Long, James J Choi

Rapid Short-pulse Ultrasound Delivers Drugs Uniformly across the Murine Blood-Brain Barrier with Negligible Disruption.

Theranostics

Published Jan 01, 1970

Neuron labeling with rhodamine-conjugated Gd-based MRI contrast agents delivered to the brain via focused ultrasound.

Authors

Sophie V Morse, Tamara Boltersdorf, Bethany I Harriss, Tiffany G Chan, Nicoleta Baxan, Hee Seok Jung, Antonios N Pouliopoulos, James J Choi, Nicholas J Long

Neuron labeling with rhodamine-conjugated Gd-based MRI contrast agents delivered to the brain via focused ultrasound.

Mov Disord

Published Jan 01, 1970

Embedding Patient Input in Outcome Measures for Long-Term Disease-Modifying Parkinson Disease Trials.

Authors

Cristina Gonzalez-Robles, Michèle Bartlett, Matthew Burnell, Caroline S Clarke, Shlomi Haar, Michele T Hu, Brook Huxford, Ashwani Jha, Michael Lawton, Alastair Noyce, Paola Piccini, Kuhan Pushparatnam, Lynn Rochester, Carroll Siu, Daniel van Wamelen, Caroline H Williams-Gray, Marie-Louise Zeissler, Henrik Zetterberg, Camille B Carroll, Thomas Foltynie, Rimona S Weil, Anette Schrag,

Embedding Patient Input in Outcome Measures for Long-Term Disease-Modifying Parkinson Disease Trials.

Intensive Care Med

Published Jan 01, 1970

Natural history, trajectory, and management of mechanically ventilated COVID-19 patients in the United Kingdom.

Authors

Brijesh V Patel, Shlomi Haar, Rhodri Handslip, Chaiyawan Auepanwiriyakul, Teresa Mei-Ling Lee, Sunil Patel, J Alex Harston, Feargus Hosking-Jervis, Donna Kelly, Barnaby Sanderson, Barbara Borgatta, Kate Tatham, Ingeborg Welters, Luigi Camporota, Anthony C Gordon, Matthieu Komorowski, David Antcliffe, John R Prowle, Zudin Puthucheary, Aldo A Faisal,

Natural history, trajectory, and management of mechanically ventilated COVID-19 patients in the United Kingdom.

Front Hum Neurosci

Published Jan 01, 1970

Brain Activity Reveals Multiple Motor-Learning Mechanisms in a Real-World Task.

Authors

Shlomi Haar, A Aldo Faisal

Brain Activity Reveals Multiple Motor-Learning Mechanisms in a Real-World Task.