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Tim Bartels

Dr Tim Bartels

((he/him))

Group Leader

Untangling protein structure to better understand function and treat neurodegeneration

Techniques

Advanced microscopy & imaging, Advanced spectroscopy, Biophysical techniques, Experimental medicine, Flow cytometry, Fluid biomarkers, Lipidomics, Mass spec-based proteomics, Stem cells / iPSCs, Structural biology, Viral-mediated expression

Biography

Dr. Tim Bartels initially finished his MSc in Chemistry and Medical Engineering in 2005 at the Technical University Munich. In 2008 he received his PhD in Biophysics working at the Adolf Butenandt Institute (Director Christian Haass) at the Ludwig-Maximilian University (supervisors Johannes Buchner and Klaus Beyer). He completed his postdoctoral training at the Center for Neurologic Diseases/Harvard Medical School with Dennis Selkoe in 2011, where he also held his first faculty positions (Instructor of Neurology 2012-2016, assistant professor 2016-2019). 

Since 2018 he is leading the program “Structure-Function Relationship in Neurodegeneration” at the Dementia Research Institute at the University College London. His lab is dedicated to the involvement of the different forms of the presynaptic protein alpha-synuclein in Parkinson’s Disease and Dementia with Lewy Bodies. Furthermore, his lab is interested in novel context specific pathways of protein folding/misfolding and the involvement of lipids, non-neuronal cells and the gut-brain axis in neurodegeneration.   

News

Key publications

Cell reports
Published
Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson's disease
Authors
Elena Eubanks, Katelyn VanderSleen, Jiya Mody, Neha Patel, Benjamin Sacks, Mahsa Darestani Farahani, Jinying Wang, Jordan Elliott, Nora Jaber, Fulya Akçimen, Sara Bandres-Ciga, Fadel Helweh, Jun Liu, Sanjana Archakam, Robert Kimelman, Bineet Sharma, Philip Socha, Ananya Guntur, Yiming Huang, Nagendran Ramalingam, Elyse Guadagno, Tim Bartels, Ulf Dettmer, M Maral Mouradian, Amir Houshang Bahrami, Wei Dai, Jean Baum, Zheng Shi, John Hardy, Eleanna Kara
Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson's disease
bioRxiv : the preprint server for biology
Published
Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson's disease
Authors
Elena Eubanks, Katelyn VanderSleen, Jiya Mody, Neha Patel, Benjamin Sacks, Mahsa Darestani Farahani, Jinying Wang, Jordan Elliott, Nora Jaber, Fulya Akçimen, Sara Bandres-Ciga, Fadel Helweh, Jun Liu, Sanjana Archakam, Robert Kimelman, Bineet Sharma, Philip Socha, Ananya Guntur, Tim Bartels, Ulf Dettmer, M Maral Mouradian, Amir Houshang Bahrami, Wei Dai, Jean Baum, Zheng Shi, John Hardy, Eleanna Kara
Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson's disease

Bartels Lab

Explore the work of the Bartels Lab focused on untangling protein structure to better understand function and treat neurodegeneration

PET tracer imaging from the Bartels Lab