Labs

Our research teams

The labs at the UK DRI are where discovery happens. Led by our Group Leaders and Emerging Leaders, they are dynamic hubs of innovation, bringing together researchers at all career stages to investigate the fundamental mechanisms of dementia. Each lab contributes unique expertise and approaches to our collective mission, creating a vibrant ecosystem of scientific inquiry that spans molecular biology, genetics, immune biology, and beyond.

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Shaw Lab

Pioneering gene therapies to treat amyotrophic lateral sclerosis and frontotemporal dementia

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A dna strand illustration in blue and gold

Skene Lab

Identifying the cell types and intracellular processes affected by the genetic loci which underlie neurodegenerative diseases

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Sogorb-Esteve Lab

Identifying biomarkers to assess synaptic dysfunction in frontotemporal dementia

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Human iPSC neurons from researcher Jamie Toombs

Spires-Jones Lab

Deciphering why synapses and neurons degenerate and whether boosting resilience of synapses can protect the brain

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Fluorescence to label different cells and structures of a brain

Tabrizi Lab

Modulating DNA repair and repeat instability for treating Huntington’s disease and related disorders

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Microglia around an amyloid plaque

Taylor Lab

Working to understand how rare coding variants that alter disease risk impact the behaviour of microglia in Alzheimer's

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RNA

Ule Lab

Deciphering the role of RNA in amyotrophic lateral sclerosis and frontotemporal dementia

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Minder living lab

Vaidyanathan Lab

Developing a family of robotic devices that can engage people living with dementia, helping improve safety in the home and enhancing quality of life

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Superintendent Radiographer Charlotte Jardine examines a patient with an MRI machine

Wardlaw Lab

Discovering how small vessel disease damages the brain and what we can do to prevent or treat it

Learn more Wardlaw Lab